OCCUPATIONAL ENVIRONMENTAL EXPOSURES AND CARDIAC STRUCTURE AND FUNCTION: THE ECHOCARDIOGRAPHIC STUDY OF LATINOS (ECHO-SOL)

Background: The relationship between alcohol consumption and clinical heart failure has been extensively studied. There have been little longitudinal data documenting alcohol effects on cardiac structure and function in a community-based population. Methods: The second Echocardiographic Study of Latinos (ECHO-SOL2) was designed to provide echocardiographic parameters that characterized longitudinal cardiac structure and function in a random and representative sample of 1,818 participants ≥45 years old. Participants underwent to serial echocardiograms at 2011-2014 (exam 1) and ~5-6 years later at 2016-2019 (exam 2). Quantification of alcohol was created on a gender-specific basis. Multiple linear regression models were adjusted for age and sex. Results: The mean age at enrollment was 56.4 years old, 57% were women. At baseline, impaired left ventricular (LV) systolic function and increased right ventricular (RV) function were associated with binge drinkers (P = 0.01). At 5-6 years later, heavy drinkers had a significant decrease in LV ejection fraction (P = 0.01). Moderate and binge drinkers demonstrated worsening diastolic function over time (P ≤ 0.01). Binge drinkers demonstrated a progressive decrease in LV mass index (P = 0.02), decrease in LV stroke volume (P = 0.01) and further reduction in RV function (P < 0.01). Conclusion: Alcohol consumption was associated with longitudinal changes in cardiac structure and function, mostly among binge drinkers, which can lead to impaired myocardial contractility compared to nondrinkers.

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Association of Cardiac Structure and Function With Neurocognition in Hispanics/Latinos: The Echocardiographic Study of Latinos

Mayo Clinic Proceedings Innovations Quality & Outcomes ◽

10.1016/j.mayocpiqo.2018.02.003 ◽

2018 ◽

Vol 2 (2) ◽

pp. 165-175

Author(s):

Mohamed Faher Almahmoud ◽

Hector M. Gonzalez ◽

Katrina Swett ◽

Wassim Tarraf ◽

Neil Schneiderman ◽

...

Keyword(s):

Structure And Function ◽

Cardiac Structure ◽

Echocardiographic Study ◽

Cardiac Structure And Function ◽

And Function

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Association of acculturation with cardiac structure and function among Hispanics/Latinos: a cross-sectional analysis of the echocardiographic study of Latinos

BMJ Open ◽

10.1136/bmjopen-2018-028729 ◽

2019 ◽

Vol 9 (11) ◽

pp. e028729 ◽

Cited By ~ 1

Author(s):

Lenny López ◽

Katrina Swett ◽

Fátima Rodriguez ◽

Jorge R Kizer ◽

Frank Penedo ◽

...

Keyword(s):

Structure And Function ◽

Volume Index ◽

Secondary Outcome ◽

Cardiac Structure ◽

Foreign Born ◽

Cross Sectional ◽

Echocardiographic Study ◽

Echocardiographic Assessment ◽

Cardiac Structure And Function ◽

And Function

ObjectiveHispanics/Latinos, the largest immigrant population in the USA, undergo the process of acculturation and have a large burden of heart failure risk. Few studies have examined the association of acculturation on cardiac structure and function.DesignCross-sectional.SettingThe Echocardiographic Study of Latinos.Participants1818 Hispanic adult participants with baseline echocardiographic assessment and acculturation measured by the Short Acculturation Scale, nativity, age at immigration, length of US residence, generational status and language.Primary and secondary outcome measuresEchocardiographic assessment of left atrial volume index (LAVI), left ventricular mass index (LVMI), early diastolic transmitral inflow and mitral annular velocities.ResultsThe study population was predominantly Spanish-speaking and foreign-born with mean residence in the US of 22.7 years, mean age of 56.4 years; 50% had hypertension, 28% had diabetes and 44% had a body mass index >30 kg/m2. Multivariable analyses demonstrated higher LAVI with increasing years of US residence. Foreign-born and first-generation participants had higher E/e′ but lower LAVI and e′ velocities compared with the second generation. Higher acculturation and income >$20K were associated with higher LVMI, LAVI and E/e′ but lower e′ velocities. Preferential Spanish-speakers with an income <$20K had a higher E/e′.ConclusionsAcculturation was associated with abnormal cardiac structure and function, with some effect modification by socioeconomic status.

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Associations between physical activity, sedentary behaviour and left ventricular structure and function from the Echocardiographic Study of Latinos (ECHO-SOL)

Open Heart ◽

10.1136/openhrt-2021-001647 ◽

2021 ◽

Vol 8 (2) ◽

pp. e001647

Author(s):

Andrew E Berdy ◽

Bharathi Upadhya ◽

Sonia Ponce ◽

Katrina Swett ◽

Richard B Stacey ◽

...

Keyword(s):

Physical Activity ◽

Sedentary Behaviour ◽

Left Ventricular ◽

Structure And Function ◽

Volume Index ◽

Cardiac Structure ◽

Echocardiographic Study ◽

Modifiable Factors ◽

Cardiac Structure And Function ◽

And Function

ObjectiveThe cross-sectional association between accelerometer-measured physical activity (PA), sedentary behaviour (SB) and cardiac structure and function is less well described. This study’s primary aim was to compare echocardiographic measures of cardiac structure and function with accelerometer measured PA and SB.MethodsParticipants included 1206 self-identified Hispanic/Latino men and women, age 45–74 years, from the Echocardiographic Study of Latinos. Standard echocardiographic measures included M-mode, two-dimensional, spectral, tissue Doppler and myocardial strain. Participants wore an Actical accelerometer at the hip for 1 week.ResultsThe mean±SE age for the cohort was 56±0.4 years, 57% were women. Average moderate to vigorous PA (MVPA) was 21±1.1 min/day, light PA was 217±4.2 min/day and SB was 737±8.1 min/day. Both higher levels of light PA and MVPA (min/day) were associated with lower left ventricular (LV) mass index (LVMI)/end-diastolic volume and a lower E/e′ ratio. Higher levels of MVPA (min/day) were associated with better right ventricular systolic function. Higher levels of SB were associated with increased LVMI. In a multivariable linear regression model adjusted for demographics and cardiovascular disease modifiable factors, every 10 additional min/day of light PA was associated with a 0.03 mL/m2 increase in left atrial volume index (LAVI) (p<0.01) and a 0.004 cm increase in tricuspid annular plane systolic excursion (p<0.01); every 10 additional min/day of MVPA was associated with a 0.18 mL/m2 increase in LAVI (p<0.01) and a 0.24% improvement in global circumferential strain (p<0.01).ConclusionsOur findings highlight the potential positive association between the MVPA and light PA on cardiac structure and function.

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Sequential changes in cardiac structure and function in patients with Duchenne type muscular dystrophy: A two-dimensional echocardiographic study

American Heart Journal ◽

10.1016/s0002-8703(98)70057-2 ◽

1998 ◽

Vol 135 (6) ◽

pp. 937-944 ◽

Cited By ~ 55

Author(s):

Kazuya Sasaki ◽

Konomi Sakata ◽

Eisei Kachi ◽

Shunkichi Hirata ◽

Tadayuki Ishihara ◽

...

Keyword(s):

Muscular Dystrophy ◽

Structure And Function ◽

Cardiac Structure ◽

Two Dimensional ◽

Echocardiographic Study ◽

Cardiac Structure And Function ◽

And Function

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Rationale and Design of a Multicenter Echocardiographic Study to Assess the Relationship Between Cardiac Structure and Function and Heart Failure Risk in a Biracial Cohort of Community-Dwelling Elderly Persons

Circulation Cardiovascular Imaging ◽

10.1161/circimaging.113.000736 ◽

2014 ◽

Vol 7 (1) ◽

pp. 173-181 ◽

Cited By ~ 55

Author(s):

Amil M. Shah ◽

Susan Cheng ◽

Hicham Skali ◽

Justina Wu ◽

Judy R. Mangion ◽

...

Keyword(s):

Heart Failure ◽

Structure And Function ◽

Community Dwelling ◽

Elderly Persons ◽

Cardiac Structure ◽

Failure Risk ◽

Echocardiographic Study ◽

Cardiac Structure And Function ◽

And Function ◽

The Relationship

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Cardiac structure and function with and without metabolic syndrome: the Echocardiographic Study of Latinos (Echo-SOL)

BMJ Open Diabetes Research & Care ◽

10.1136/bmjdrc-2017-000484 ◽

2018 ◽

Vol 6 (1) ◽

pp. e000484 ◽

Cited By ~ 1

Author(s):

Melissa Burroughs Peña ◽

Katrina Swett ◽

Neil Schneiderman ◽

Daniel M Spevack ◽

Sonia G Ponce ◽

...

Keyword(s):

Metabolic Syndrome ◽

Longitudinal Strain ◽

Left Ventricular ◽

Normal Weight ◽

Structure And Function ◽

Cardiac Structure ◽

Echocardiographic Study ◽

Confounding Variables ◽

Cardiac Structure And Function ◽

And Function

ObjectiveWe assessed the hypothesis that metabolic syndrome is associated with adverse changes in cardiac structure and function in participants of the Echocardiographic Study of Latinos (Echo-SOL).MethodsNon-diabetic Echo-SOL participants were included in this cross-sectional analysis. Metabolic syndrome was defined according to the American Heart Association/National Heart, Lung, and Blood Institute 2009 Joint Scientific Statement. Survey multivariable linear regression analyses using sampling weights were used adjusting for multiple potential confounding variables. Additional analysis was stratified according to the presence/absence of obesity (body mass index (BMI) ≥25 kg/m2) and the presence/absence of metabolic syndrome.ResultsWithin Echo-SOL, 1260 individuals met inclusion criteria (59% female; mean age 55.2 years). Compared with individuals without metabolic syndrome, those with metabolic syndrome had lower medial and lateral E′ velocities (−0.4 cm/s, (SE 0.1), p=0.0002; −0.5 cm/s (0.2), p=0.02, respectively), greater E/E′ (0.5(0.2), p=0.01) and worse two-chamber left ventricular longitudinal strain (0.9%(0.3), p=0.009), after adjusting for potential confounding variables. Increased left ventricular mass index (9.8 g/m2 (1.9), p<0.0001 and 7.5 g/m2 (1.7), p<0.0001), left ventricular end-diastolic volume (11.1 mL (3.0), p=0.0003 and 13.3 mL (2.7), p<0.0001), left ventricular end-systolic volume (5.0 mL (1.4), p=0.0004 and 5.7 mL (1.3) p<0.0001) and left ventricular stroke volume (10.2 mL (1.8), p<0.0001 and 13.0 mL (2.0), p<0.0001) were observed in obese individuals with and without metabolic syndrome compared with individuals with normal weight without metabolic syndrome. In sensitivity analyses, individuals with normal weight (BMI <25 kg/m2) and metabolic syndrome had worse left ventricular global longitudinal strain (2.1%(0.7), p=0.002) and reduced left ventricular ejection fraction (−3.5%(1.4), p=0.007) compared with normal-weight individuals without metabolic syndrome.ConclusionsIn a sample of US Hispanics/Latinos metabolic syndrome was associated with worse left ventricular systolic and diastolic function. Adverse changes in left ventricular size and function were observed in obese individuals with and without metabolic syndrome but decreased left ventricular function was also present in normal-weight individuals with metabolic syndrome.

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