ALPHA-BLOCKER USE AND CLINICAL OUTCOMES FOLLOWING PERCUTANEOUS CORONARY INTERVENTION

Objectives The deleterious effects of psychological problems on coronary heart disease (CHD) are not satisfactorily explained. We explored influential factors associated with mortality in psycho-cardiological disease in a Chinese sample. Methods Of 7460 cardiac patients, we selected 132 patients with CHD and mental illness. Follow-up was conducted via telephone. We analyzed clinical characteristics, clinical outcomes, and survival. Results The clinical detection rate of psycho-cardiological disease in the overall patient population was 1.8%. Of these, 113 patients completed follow-up; 18 died owing to cardiovascular diseases during follow-up. Kaplan–Meier analysis showed dysphagia, limb function, self-care ability, percutaneous coronary intervention, low-density lipoprotein, total cholesterol, pro-brain natriuretic peptide and high-sensitivity (hs) troponin T had significant associations with cumulative survival. Cox regression analysis showed total cholesterol (hazard ratio [HR]: 2.765, 95% confidence interval [CI]: 1.001–7.641), hs troponin T (HR: 4.668, 95% CI: 1.293–16.854), and percutaneous coronary intervention (HR: 3.619, 95% CI: 1.383–9.474) were independently associated with cumulative survival. Conclusions The clinical detection rate of psycho-cardiological disease was far lower than expected. Normal total cholesterol and hs troponin T were associated with reduced cardiovascular disease mortality over 2 years. Percutaneous coronary intervention is a prognostic risk factor in patients with psycho-cardiological disease.

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The Impact of Renal Dysfunction on the Long Term Clinical Outcomes of Diabetic Patients Undergoing Percutaneous Coronary Intervention in the Drug-Eluting Stent Era

PLoS ONE ◽

10.1371/journal.pone.0141846 ◽

2016 ◽

Vol 11 (1) ◽

pp. e0141846 ◽

Cited By ~ 1

Author(s):

Ki Hong Choi ◽

Jeong Hoon Yang ◽

Ji Hwan Kim ◽

Young Bin Song ◽

Joo-Yong Hahn ◽

...

Keyword(s):

Percutaneous Coronary Intervention ◽

Renal Dysfunction ◽

Clinical Outcomes ◽

Coronary Intervention ◽

Drug Eluting Stent ◽

Diabetic Patients ◽

Percutaneous Coronary ◽

Drug Eluting ◽

The Impact

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Differing effects of beta-blockers on long-term clinical outcomes following percutaneous coronary intervention between patients with mid-range and reduced left ventricular ejection fraction

BMC Cardiovascular Disorders ◽

10.1186/s12872-021-01850-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Jun Shitara ◽

Ryo Naito ◽

Takatoshi Kasai ◽

Hirohisa Endo ◽

Hideki Wada ◽

...

Keyword(s):

Percutaneous Coronary Intervention ◽

Ejection Fraction ◽

Clinical Outcomes ◽

Beta Blockers ◽

Coronary Intervention ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Coronary Syndrome ◽

Percutaneous Coronary

Abstract Background The aim of this study was to determine the difference in effects of beta-blockers on long-term clinical outcomes between ischemic heart disease (IHD) patients with mid-range ejection fraction (mrEF) and those with reduced ejection fraction (rEF). Methods Data were assessed of 3508 consecutive IHD patients who underwent percutaneous coronary intervention (PCI) between 1997 and 2011. Among them, 316 patients with mrEF (EF = 40–49%) and 201 patients with rEF (EF < 40%) were identified. They were assigned to groups according to users and non-users of beta-blockers and effects of beta-blockers were assessed between mrEF and rEF patients, separately. The primary outcome was a composite of all-cause death and non-fatal acute coronary syndrome. Results The median follow-up period was 5.5 years in mrEF patients and 4.3 years in rEF patients. Cumulative event-free survival was significantly lower in the group with beta-blockers than in the group without beta-blockers in rEF (p = 0.003), whereas no difference was observed in mrEF (p = 0.137) between those with and without beta-blockers. In the multivariate analysis, use of beta-blockers was associated with reduction in clinical outcomes in patients with rEF (hazard ratio (HR), 0.59; 95% confidence interval (CI), 0.36–0.97; p = 0.036), whereas no association was observed among those with mrEF (HR 0.74; 95% CI 0.49–1.10; p = 0.137). Conclusions Our observational study showed that use of beta-blockers was not associated with long-term clinical outcomes in IHD patients with mrEF, whereas a significant association was observed in those with rEF.

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