The DRD2 gene and the risk for alcohol dependence in bipolar patients

2000 ◽  
Vol 15 (2) ◽  
pp. 103-108 ◽  
Author(s):  
P. Gorwood ◽  
F. Bellivier ◽  
J. Adès ◽  
M. Leboyer
Keyword(s):  
Bipolar Disorder ◽  
Alcohol Dependence ◽  
Dopamine Receptor ◽  
Receptor Gene ◽  
D2 Dopamine Receptor ◽  
Drd2 Gene ◽  
Gene Encoding ◽  
Co Morbidity ◽  
Bipolar Patients

SummaryThe high co-morbidity between bipolar disorder and alcohol dependence may have different explanations, one of them being the existence of common genetic factors for the two disorders. Several candidate genes may be involved but the genes acting in the dopaminergic pathway may be more specifically involved. We have thus tested the role of the gene encoding the D2 dopamine receptor (TaqI A1 allele) in the potentially shared vulnerability to alcohol dependence and bipolar disorder.One hundred and twenty-two French (for at least two generations) patients were recruited on the basis of hospital or outpatient files and were interviewed with the DIGS. The A1 allele frequencies were compared between four groups, namely, with bipolar patients and co-morbid alcohol dependence (N = 21), with bipolar patients without alcohol morbidity (N = 31), with alcohol dependence without mood disorder (N = 35) and unaffected controls (N = 35).The Hardy Weinberg equilibrium for the DRD2 Taq1 A1 genotypes was respected for the sample as a whole, and for each subsample. We observed that 42.9% of control subjects have at least one A1 allele, a frequency which is not significantly different from the one observed in the affected sample as a whole (39.1%), neither from patients with alcohol dependence (37.1%), patients with bipolar disorder (48.4%) nor patients with alcohol dependence and bipolar disorder (28.6%). The regression analysis based on the three variables (bipolar disorder, alcohol dependence and interaction between these two disorders) does not explain the presence of the A1 allele of the DRD2 gene.We thus found no evidence for a significant role of the A1 allele of the D2 dopamine receptor gene in the specific association between bipolar disorder and alcohol dependence in our sample.

D2 dopamine receptor (DRD2) polymorphism is associated with severity of alcohol dependence

2002 ◽  
Vol 17 (1) ◽  
pp. 17-23 ◽  
Author(s):  
J.P. Connor ◽  
R.McD. Young ◽  
B.R. Lawford ◽  
T.L. Ritchie ◽  
E.P. Noble
Keyword(s):  
Alcohol Dependence ◽  
Dopamine Receptor ◽  
Problem Drinking ◽  
Drinking Behavior ◽  
D2 Dopamine Receptor ◽  
Drd2 Gene ◽  
Allele Status ◽  
Alcohol Detoxification ◽  
Dependence Scale ◽  
Alcohol Dependent

SummaryThe A1 allele of the D2 dopamine receptor (DRD2) gene has been associated with alcohol dependence. However, the expression of this allele risk on the severity of drinking behavior in patients with alcohol dependence has not been systematically explored. The present study examines the association between DRD2 A1+(A1/A1 and A1/A2 genotypes) and A1– (A2/A2 genotype) allele status and key drinking parameters in alcohol-dependent patients. A sample of Caucasian adults was recruited from an alcohol detoxification unit. A clinical interview and the Alcohol Dependence Scale (ADS) questionnaire provided data on consumption, dependence, chronology of drinking and prior detoxification. A1+ allele compared to A1– allele patients consumed higher quantities of alcohol, commenced problem drinking at an earlier age, experienced a shorter latency between first introduction to alcohol to the onset of problem drinking and had higher ADS scores. Moreover, A1+ allele patients had more detoxification attempts than their A1– allele counterparts. In sum, alcohol-dependent patients with the DRD2 A1 allele compared to patients without this allele are characterized by greater severity of their disorder across a range of problem drinking indices. The implications of these findings are discussed.

Role of trace amine associated receptor 1 (TAAR1) in D2 dopamine receptor-related behavior and signaling

2012 ◽  
Author(s):  
S. Espinoza ◽  
F. Manago ◽  
M. Messa ◽  
T. D. Sotnikova ◽  
M. Caron ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
D2 Dopamine Receptor ◽  
Trace Amine

Role of Trace Amine Associated Receptor 1 (TAAR1) in D2 Dopamine receptor-related behavior and signaling

2012 ◽  
Author(s):  
S. Espinoza ◽  
F. Manago ◽  
M. Messa ◽  
T. D. Sotnikova ◽  
M. Caron ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
D2 Dopamine Receptor ◽  
Trace Amine

scholarly journals A Prospective Comparison of Bipolar I and II Subjects With and Without Comorbid Alcohol Dependence From the COGA Dataset

2020 ◽  
Vol 11 ◽  
Author(s):  
Ulrich W. Preuss ◽  
M. N. Hesselbrock ◽  
V. M. Hesselbrock
Keyword(s):  
Bipolar Disorder ◽  
Alcohol Use ◽  
Alcohol Dependence ◽  
Collaborative Study ◽  
Structured Interviews ◽  
Prospective Comparison ◽  
Bipolar Ii ◽  
Bipolar Patients ◽  
Alcohol Dependent

Objective: Comorbidity of alcohol use disorders in bipolar subjects is high as indicated by epidemiological and clinical studies. Though a more severe course of bipolar disorder in subjects with comorbid alcohol dependence has been reported, fewer studies considered the longitudinal course of alcohol dependence in bipolar subjects and the prospective course of comorbid bipolar II subjects. Beside baseline analysis, longitudinal data of the COGA (Collaborative Study on Genetics in Alcoholism) were used to evaluate the course of bipolar I and II disordered subjects with and without comorbid alcohol dependence over more than 5 years of follow-up.Methods: Characteristics of bipolar disorder, alcohol dependence and comorbid psychiatric disorders were assessed using semi-structured interviews (SSAGA) at baseline and at a 5-year follow-up. Two hundred twenty-eight bipolar I and II patients were subdivided into groups with and without comorbid alcohol dependence.Results: Of the 152 bipolar I and 76 bipolar II patients, 172 (75, 4%) had a comorbid diagnosis of alcohol dependence. Bipolar I patients with alcohol dependence, in particular women, had a more severe course of bipolar disorder, worse social functioning and more suicidal behavior than all other groups of subjects during the 5-year follow-up. In contrast, alcohol dependence improved significantly in both comorbid bipolar I and II individuals during this time.Conclusions: A 5-year prospective evaluation of bipolar patients with and without alcohol dependence confirmed previous investigations suggesting a more severe course of bipolar disorder in comorbid bipolar I individuals, whereas bipolar II individuals were less severely impaired by comorbid alcohol use disorder. While severity of alcohol dependence improved during this time in comorbid alcohol-dependent bipolar I patients, the unfavorable outcome for these individuals might be due to the higher comorbidity with personality and other substance use disorders which, together with alcohol dependence, eventually lead to poorer symptomatic and functional clinical outcomes.

Age at onset in bipolar disorder: Investigation of the role of TaqIA polymorphism of DRD2 gene in a Sardinian sample

2011 ◽  
Vol 26 (3) ◽  
pp. 141-143 ◽  
Author(s):  
A. Squassina ◽  
M. Manchia ◽  
M. Costa ◽  
C. Chillotti ◽  
R. Ardau ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Association Study ◽  
Early Onset ◽  
Psychiatric Illness ◽  
Age At Onset ◽  
Drd2 Gene ◽  
Genetic Complexity

AbstractBipolar disorder (BD) is a highly heterogeneous and heritable psychiatric illness. Age at onset has been shown to be a powerful tool for dissecting both the phenotypic and genetic complexity of BD. In this article, we present findings from an association study between the DRD2 TaqIA polymorphism and age at onset, showing that both alleles and genotypes at this locus associate with early onset BD.

The Expanding Role of Antipsychotics

CNS Spectrums ◽  
2004 ◽  
Vol 9 (S1) ◽  
pp. 7-12
Author(s):  
Philip G. Janicak
Keyword(s):  
Bipolar Disorder ◽  
Manic Episode ◽  
Acute Mania ◽  
Psychotic Symptoms ◽  
Primary Therapy ◽  
Obsessive Compulsive ◽  
Stabilizing Agent ◽  
Compulsive Disorder ◽  
Bipolar Patients

Antipsychotics have been utilized in the treatment of bipolar disorder for many decades and were the mainstay of treatment before lithium was reintroduced in the late 1960s. Today, many bipolar patients who present with psychotic features are misdiagnosed and prescribed an antipsychotic for another disorder. Estimates of psychotic symptoms in bipolar disorder, particularly during a manic episode, are ≥50% by clinical assessment and even higher by individual reports. Thus, antipsychotics are frequently used: as first treatment for psychosis not recognized as bipolar disorder, and as an adjunct to a mood-stabilizing agent in bipolars with psychotic symptoms.Most recently, antipsychotics have been examined for their mood-stabilizing properties as well (Slide 9). One may conceptualize using a selective serotonin reuptake inhibitor (SSRI) antidepressant for disorders such as panic disorder or obsessive-compulsive disorder, and using an antiepileptic as a mood-stabilizing agent; however, it is more difficult to accept that an agent approved for treatment of psychosis can be a primary therapy for bipolar disorder. Data from the monotherapy trials suggest that second-generation antipsychotics (SGAs) are at least as effective as lithium and valproic acid for acute mania. There is a very large database indicating that SGAs can be utilized as monotherapy for acute mania. However, there is limited data on the role of these agents in prevention of relapse and recurrence and in their efficacy for depression in the context of bipolar disorder. More studies will be needed to clarify whether SGAs should be used as monotherapy or whether they would be best used as augmenting agents in severe and psychotically manic or depressed patients.

Lack of association between alcohol-dependence and D3 dopamine receptor gene in three independent samples

1995 ◽  
Vol 60 (6) ◽  
pp. 529-531 ◽  
Author(s):  
P. Gorwood ◽  
M. P. Martres ◽  
J. Adès ◽  
P. Sokoloff ◽  
E. P. Noble ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Dopamine Receptor ◽  
Receptor Gene ◽  
Dopamine Receptor Gene
Sign in / Sign up

Export Citation Format

Share Document