Neurocognitive Predictors of Functioning in Schizophrenia: Five Years Follow Up Study

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
M.L. Vargas ◽  
J.C. Sanz ◽  
N. Jimeno-Bulnes ◽  
S. Lopez
Keyword(s):  
Processing Speed ◽  
Verbal Memory ◽  
Verbal Learning ◽  
Outcome Variable ◽  
California Verbal Learning Test ◽  
Linear Regression Models ◽  
Psychiatric Admission ◽  
Processing Speed Index ◽  
Learning Test

Aims:Verbal memory and processing speed are two of the proposed neurocognitive predictors in schizophrenia. the objective is to determinate neurocognitive predictors of functioning in one five years follow-up period on ambulatory schizophrenia patients.Method:We conduct one cohort study on 30 schizophrenia out-patients (19 male; age mean: 32.8 years; SD:7.2). at the moment of inclusion it was applied one neuropsychological battery sensitive to neuropsychological deficit in schizophrenia: WAIS-III, BADS, WCST, Colour Trails, Trail Making A and B, BVRT, California Verbal Learning Test (Spanish version: TAVEC). Variables was summarized determining Z values and principal components. the cohort was prospectively studied for up to five years. as result variables it were considered: time to the first antipsychotic-drug change, time to the first psychiatric admission, and average five-years annual score in the Strauss-Carpenter Outcome Scale. It was constructed Cox and Linear Regression Models to determinate the better predicting neurocognitive components.Results:The better global outcome was directly related with WAIS-III processing speed index (corrected R square: 0.19; p = 0.02; beta constant= 0.469; beta WAIS-III processing speed= 0.125). None predictor was selected for the outcome variable change of antipsychotic. Psychiatric admission was predicted (p=0.006) by implicit learning (beta= -2.19), executive functioning (beta= 1.02), WAIS-III Total IQ (beta= 0.45) and WAIS-III Perceptual Organization Index (beta= -0.20).Conclusion:Higher processing speed index predicts one better functioning outcome during five-years follow-up. the risk for psychiatric admission was heterogeneously related with neurocognitive predictors. Verbal memory did not predict functional outcome.

scholarly journals Remote assessment of verbal memory in MS patients using the California Verbal Learning Test

2017 ◽  
Vol 24 (3) ◽  
pp. 354-357 ◽  
Author(s):  
Lisa F Barcellos ◽  
Kalliope H Bellesis ◽  
Ling Shen ◽  
Xiaorong Shao ◽  
Terrence Chinn ◽  
...  
Keyword(s):  
Verbal Memory ◽  
Cognitive Assessment ◽  
Verbal Learning ◽  
California Verbal Learning Test ◽  
Healthy Controls ◽  
Factor Analyses ◽  
Assessment Protocol ◽  
Remote Assessment ◽  
Patient Groups ◽  
Learning Test

We used the California Verbal Learning Test, Second Edition (CVLT-II), one component of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS), to determine feasibility of a remote assessment protocol. We compared telephone-administered CVLT-II data from MS patients to data acquired in person from an independent sample of patients and healthy controls. Mixed factor analyses of variance (ANOVAs) showed no significant differences between patient groups, but between-group effects comparing patients and healthy controls were significant. In this study, CVLT-II assessment by conventional in-person and remote telephone assessment yielded indistinguishable results. The findings indicate that telephone-administered CVLT-II is feasible. Further validation studies are underway.

scholarly journals A-182 Convergent and Divergent Validity of the ChAMP with the CVLT-C and RCFT in Children with Epilepsy

2020 ◽  
Vol 35 (6) ◽  
pp. 977-977
Author(s):  
David C ◽  
Brooks B ◽  
Macallister W
Keyword(s):  
Verbal Memory ◽  
Visual Memory ◽  
Verbal Learning ◽  
California Verbal Learning Test ◽  
Divergent Validity ◽  
Complex Figure ◽  
Visual Tasks ◽  
Convergent And Divergent Validity ◽  
Learning Test ◽  
Figure Test

Abstract Objective As new measures of memory become available, clinicians may be cautious to adopt them without evidence supporting their validity. The present study assesses the convergent and divergent validity of the Child and Adolescent Memory Profile (ChAMP), with the California Verbal Learning Test Children’s (CVLT-C) and the Rey Complex Figure Test (RCFT) in children with epilepsy. Method Twenty four clinically referred children (16 female, 8 male, - age = 12.37 years, SD = 2.68) completed the ChAMP, CVLT-C, and RCFT. Pearson correlations assessed the ChAMP’s convergent and divergent validity with the CVLT-C and the RCFT. Base rate of impairment was calculated for scores ≤2nd percentile. Results The ChAMP verbal tasks demonstrated strong relations with CVLT-C (lists; r = 0.678 p = < .001, instructions; r = 0.724 p = < .001 with CVLT-C learning trials and ChAMP lists free recall with CVLT-C long delay r = 0.580 p = .003). The ChAMP visual tasks correlated strongly with the RCFT delay (objects; r = 0.570 p = .004, places; r = 0.619 p = .001, Visual Memory Index; r = 0.657 p = < .001). However, divergent validity was limited as ChAMP Verbal Memory Index correlated with RCFT delay (r = 0.550 p = .005) and ChAMP Visual Memory Index with CVLT-C delay (r = 0.606 p = .002). Eight percent were deemed impaired on ChAMP lists delay similar to the CVLT-C delay (13%), however, ChAMP places delay identified 21% impaired, compared to the RCFT delay (42%). Conclusions ChAMP scores are strongly correlated with older established measures, but identify fewer cases as clinically impaired. This may reflect the more contemporary normative data or the fact that ChAMP tasks are less multifactorial in nature than are the CVLT-C and RCFT.

Identification of Subtle Verbal Memory Deficits in Premanifest Huntington Disease Using the California Verbal Learning Test

2020 ◽  
Vol 33 (1) ◽  
pp. 16-22 ◽  
Author(s):  
Heather M. Holden ◽  
Savanna M. Tierney ◽  
Lisa V. Graves ◽  
Ilex Beltran-Najera ◽  
Steven Paul Woods ◽  
...  
Keyword(s):  
Huntington Disease ◽  
Verbal Memory ◽  
Verbal Learning ◽  
Memory Deficits ◽  
California Verbal Learning Test ◽  
Learning Test

White Matter Changes and Cognitive Decline in a Ten-Year Follow-Up Period: A Pilot Study on a Single-Center Cohort from the Leukoaraiosis and Disability Study

2016 ◽  
Vol 41 (5-6) ◽  
pp. 303-313
Author(s):  
Sofia Madureira ◽  
Ana Verdelho ◽  
Carla Moleiro ◽  
Catarina Santos ◽  
Philip Scheltens ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Verbal Learning ◽  
White Matter Lesions ◽  
Disease Assessment ◽  
California Verbal Learning Test ◽  
Clinical Diagnoses ◽  
Neuropsychological Predictors ◽  
Learning Test

Aims: To describe the contribution of white matter lesions to the long-term neuropsychological profiles of different groups of clinical diagnoses, and to identify neuropsychological predictors of cognitive impairment in a 10-year follow-up. Methods: The Lisbon subcohort of the Leukoaraiosis and Disability (LADIS) study was re-evaluated performing a clinical, functional and cognitive evaluation [including Mini-Mental State Examination (MMSE), Alzheimer's Disease Assessment Scale - Cognition (ADAS-Cog) and ADAS-Cog with the extension for vascular impairment (VADAS-Cog), the 9-word version of the California Verbal Learning Test (CVLT-9), the Trail-Making test and the Stroop test] as well as an MRI scan. Using clinical diagnostic criteria, participants were identified as having no cognitive impairment (NI), cognitive impairment but no dementia (CIND) or dementia (DEM), and the effect of time on clinical diagnosis and neuropsychological profiles was analyzed. Results: From the initial group of 66 participants, 37 out of 41 survivors (90%) were re-evaluated (mean age 81.40 years, 57% women). Fifteen patients (41%) had DEM, 12 (32%) CIND and 10 (27%) NI. Over time, the three groups presented distinct profiles in the MMSE [F2, 62 = 15.85, p = 0.000], ADAS [F2, 62 = 15.85, p = 0.000] and VADAS [F2, 48 = 5.87, p = 0.008]. Logistic regression analysis identified higher scores on MMSE (β = 1.14, p = 0.03, OR = 3.13, 95% CI 1.09-8.97) as predictors of NI after 10 years of follow-up. Conclusion: Higher scores on baseline MMSE were the only neuropsychological predictors of NI after 10 years.

Proactive inhibition and semantic organization Relationship with verbal memory in patients with schizophrenia

1996 ◽  
Vol 2 (6) ◽  
pp. 486-493 ◽  
Author(s):  
David A. Kareken ◽  
Paul J. Moberg ◽  
Ruben C. Gur
Keyword(s):  
Verbal Memory ◽  
Semantic Processing ◽  
Verbal Learning ◽  
Semantic Category ◽  
Semantic Content ◽  
Proactive Inhibition ◽  
California Verbal Learning Test ◽  
Retroactive Inhibition ◽  
Intrusion Errors ◽  
Learning Test

AbstractCompared to other cognitive functions in schizophrenia, evidence suggests that verbal memory is particularly impaired. This study used the California Verbal Learning Test (CVLT) to examine proactive inhibition (PI) and semantic processing in verbal memory in 29 patients with schizophrenia and 29 healthy controls. Patients showed significantly less PI, but also did not organize (cluster) their recall according to semantic category. Controls and patients demonstrated small retroactive inhibition (RI) effects regardless of semantic content. Although both groups made similar types and numbers of free recall intrusion errors, patients committed more phonemic and nonshared recognition errors. Results suggest that reduced semantic processing prevented build of PI, and contributes to defective memory in schizophrenia. The anatomic-physiologic abnormalities that underlie these findings may be particularly pronounced in prefrontal and temporal-parietal cortical areas. (JINS, 1996, 2, 486–493.)

scholarly journals Refined Measurement of Verbal Learning and Memory: Application of Item Response Theory to California Verbal Learning Test – Second Edition (CVLT-II) Learning Trials

2019 ◽  
Vol 35 (1) ◽  
pp. 90-104 ◽  
Author(s):  
Indrani Thiruselvam ◽  
James B Hoelzle
Keyword(s):  
Item Response Theory ◽  
Item Response ◽  
Verbal Memory ◽  
Clinical Decision Making ◽  
Verbal Learning ◽  
California Verbal Learning Test ◽  
Response Theory ◽  
Memory Ability ◽  
Learning Test ◽  
Learning Trials

Abstract Objective This study was conducted to investigate how items contained within the California Verbal Learning Test – Second Edition (CVLT-II; Delis, D. C., Kramer, J. H., Kaplan, E., & Ober, B. A. (2000). California Verbal Learning Test (2nd ed.). San Antonio, TX: Psychological Corporation) learning trials function and to evaluate whether weighted scoring approaches might improve quantification of verbal memory. Method Archival data from 577 individuals (338 healthy young adults, 239 medical or psychiatric patients referred to a neuropsychology clinic) were obtained and evaluated using item response theory. Results The serial position effect was evident across trials, but was most evident in Trials 1, 2, and 3. CVLT-II Trial 5 was the most effective among the five learning trials in quantifying verbal memory, although it was most effective when measuring lower memory ability levels. In contrast, CVLT-II Trial 1 items had, on average, the highest difficulty levels. Various weighted scoring approaches did not appear incrementally helpful in improving prediction of memory performance. Conclusion Specific items and trials differentially discriminate between examinees with low levels of memory ability; it is important to thoroughly evaluate item properties of tests used in clinical decision-making.

scholarly journals The correlation between EDSS and cognitive impairment in MS patients. Assessment of a Brazilian population using a BICAMS version

2016 ◽  
Vol 74 (12) ◽  
pp. 974-981 ◽  
Author(s):  
Marco A. G. de Caneda ◽  
Maria Cecília A. de Vecino
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Neuropsychological Tests ◽  
Verbal Learning ◽  
Therapeutic Interventions ◽  
California Verbal Learning Test ◽  
Cognitive Evaluation ◽  
Disability Status ◽  
Learning Test

ABSTRACT Multiple sclerosis (MS) may present with a cognitive impairment as disabling as the physical disabilities. Therefore, routine cognitive evaluation is pivotal. Valid and reliable neuropsychological tests are essential in follow-up and to define future therapeutic interventions. Objectives To investigate the correlation between the disabilities of MS patients and their cognitive impairment assessed by the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS). Methods Forty patients with definitive diagnoses of MS were selected. The correlation coefficient (r) between the Expanded Disability Status Scale (EDSS) and the neuropsychological tests of BICAMS were calculated. Results The correlation was clinically substantial and significant with r = 0.55 (p < 0.01) in the Symbol Digit Modalities Test (SDMT), 0.54 (p < 0.01) in the Brief Visuospacial Memory Test (BVMT) and 0.40 (p < 0.05) in the California Verbal Learning Test (CVLT). Conclusion BICAMS has easy and satisfactory application and evaluation for routine visits and presents a significant correlation with the EDSS. Its use may be indicated for screening and monitoring of cognitive impairment in patients with MS.

scholarly journals Long-term effects of risperidoneversushaloperidol on verbal memory, attention, and symptomatology in schizophrenia

2007 ◽  
Vol 14 (1) ◽  
pp. 110-118 ◽  
Author(s):  
SOPHIE RÉMILLARD ◽  
EMMANUELLE POURCHER ◽  
HENRI COHEN
Keyword(s):  
Verbal Memory ◽  
Negative Symptoms ◽  
Psychiatric Symptoms ◽  
Verbal Learning ◽  
California Verbal Learning Test ◽  
Neurocognitive Performance ◽  
Long Term Effects ◽  
Assessment Period ◽  
Learning Test

There is evidence in the literature that cognitive functions in schizophrenia (SC) may be improved by atypical neuroleptics (NLPs) in contrast to typical medication, but there is still controversy regarding this apparent superiority of atypical drugs. In this study, we assessed the differential effects of risperidone and haloperidol on verbal memory, attention, and psychiatric symptoms in SC. The performance of 28 SC participants, randomly assigned to risperidone (2–6 mg/day) or haloperidol (2–40 mg/day), was compared with that of healthy controls. The California Verbal Learning Test (CVLT), the d2 Cancellation Test, and the Positive and Negative Symptoms Scale were administered at baseline and 3, 6, and 12 months. Relative to controls, all SC participants showed markedly impaired verbal memory and processing speed at each assessment period. There was no differential effect between the two NLPs on CVLT and d2 performance. However, risperidone was more effective than haloperidol in reducing psychiatric symptoms. Improvement in symptom severity was not associated with improvement in neurocognitive performance on these specific tests. Neither conventional nor atypical neuroleptic medications improved neurocognitive functioning over a 12-month follow-up, suggesting that psychopathological improvement under risperidone is independent of cognitive function. (JINS, 2008,14, 110–118.)

scholarly journals T105. VERBAL MEMORY MEASUREMENT TOWARDS DIGITAL PERSPECTIVES IN FIRST-EPISODE PSYCHOSIS: A SYSTEMATIC REVIEW STUDY

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S270-S271
Author(s):  
Can Kilciksiz ◽  
John Torous
Keyword(s):  
Early Detection ◽  
Verbal Memory ◽  
Verbal Learning ◽  
Digital Technologies ◽  
First Episode Psychosis ◽  
First Episode ◽  
The Past ◽  
Episode Psychosis ◽  
Learning Test

Abstract Background Psychosis is a clinical syndrome which can have detrimental effects on patients in different aspects of functioning such as thought, behavior, and cognition. Even in early phases psychotic spectrum illnesses like schizophrenia, patients can experience cognitive decline prior to overt classical symptoms like delusions and hallucinations. Early detection and reducing the duration of untreated psychosis through early intervention can prevent or slow the progress of cognitive symptoms and the entire illness. Although cognition research in early psychosis has demonstrated that verbal memory is one the first cognitive domains impacted in first-episode of psychosis and continuously declines after the first-episode, it is still not clear which tests are most widely used to measure verbal memory and which may be most amenable to being translated to a digital format. In this systematic review, we assessed which verbal memory assessments are most widely used in first-episode psychosis and may be potentially applied via digital technologies (smartphone applications, telepsychiatry, chatbots, etc.) for use in early detection in the future. Methods From September to November 2019, we searched studies measured verbal memory in first-episode psychosis or schizophrenia over the past 10 years on PubMed and PsycINFO. We screened abstracts of these studies and we excluded review studies and duplicates. We downloaded full-texts of included studies to identify the verbal memory measurement tests used, follow-up frequencies, and sample sizes. Results We screened 233 papers and found that 121 original research studies measured verbal memory in first-episode psychosis over the past 10 years. Of these 121 studies, 32(%26) used Rey Auditory Verbal Learning Test (RAVLT), 29(24%) used California Verbal Learning Test (CVLT), 27(22%) used Weschler Memory Scale (WMS), 14(12%) used Hopkins Verbal Learning Test (HVLT), 4(3%) used both WMS and CVLT, 3(2%) used both WMS and RAVLT, and 12(%10) used other tests to measure verbal memory. Four (3%) of these studies specified that they used a computer, 23(20%) used paper-pen, 2(2%) studies used both, and 92(76%) studies did not specify their verbal measurement application tools. Thirty-six (30%) studies had follow-up measurements of verbal memory, while 85(70%) studies had only a single time point verbal memory measurement during the study period. Study sample sizes range from 6 to 498. Discussion We found that four main tests to measure verbal memory in first-episode psychosis are RAVLT, CVLT, WMS, and HVLT although they are not often administered via technology. Of these four verbal memory measurement tests, RAVLT is the most widely used and HVLT is easier to administer while CVLT appears able to assess a broader range of verbal memory domains. There is an emerging opportunity to apply RAVLT, CVLT, WMS, and HVLT via digital technologies for expanding access to early detection of cognitive decline in clinical high risk and first-episode psychosis.

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