Depression and anxiety following open heart surgery: Mediation of coping, spiritual struggle and interleukin-6

2011 ◽  
Vol 26 (S2) ◽  
pp. 597-597
Author(s):  
A. Ai ◽  
H. Appel ◽  
Z. Kronfol
Keyword(s):  
Mental Health ◽  
Interleukin 6 ◽  
Indirect Effects ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Well Being ◽  
Mediating Effect ◽  
Open Heart ◽  
Spiritual Struggle ◽  
Maladaptive Coping

IntroductionFactors pertaining to religion and spirituality have been linked with well-being and adequate coping. Few studies have investigated negative aspects of religious coping, such as spiritual struggle.ObjectivesBased on multidisciplinary literature and previous findings, our study's objectives are to estimate the parallel psychophysiological pathways from pre-operative distress to post-operative depression in patients undergoing open heart surgery.AimsThe study's aims are to examine the association in depression, anxiety, and how coping, spiritual struggle and interleukin-6 play a role in patients following open heart surgery.MethodsPlasma samples for interleukin-6 (IL-6) were obtained before open heart surgery. Patients’ history and demographic information obtained through interviews 2 days before surgery. Follow up interview for mental health and religious were conducted before and after surgery.ResultsThe results showed that a link between spiritual struggle and IL-6 mediated the indirect effects of pre-operative anxiety on post-operative depression. Anxiety had positive indirect effects on post-operative hostility. Further, hope played a protective mediating role to moderate the undesirable influences of the spiritual struggle-IL-6 link and maladaptive coping on post-operative mental health attributes.ConclusionsOur study estimated important psychophysiological pathways from pre-operative distress to post-operative maladjustment. To our knowledge, this model is the first analysis to demonstrate the significant mediating effect of the spiritual-IL-6 link, alongside that of positive religious copping and other maladaptive coping, in this population.

Health and well-being of children with congenital cardiac malformations, and their families, following open-heart surgery

2006 ◽  
Vol 16 (2) ◽  
pp. 157-164 ◽  
Author(s):  
Annette Majnemer ◽  
Catherine Limperopoulos ◽  
Michael Shevell ◽  
Charles Rohlicek ◽  
Bernard Rosenblatt ◽  
...  
Keyword(s):  
Heart Surgery ◽  
Open Heart Surgery ◽  
Well Being ◽  
Psychosocial Health ◽  
Stress Index ◽  
Open Heart ◽  
Normal Range ◽  
Related Quality ◽  
Health Related

Infants who survive open-heart surgery are at risk for developmental disability, which may impact on the well-being not only of the child, but also the family. The objective of our prospective study, therefore, was to determine the long-term health-related quality of life of children with congenital cardiac malformations following open-heart surgery, and to describe the persisting level of stress in their families. To this end, 49 parents completed the Child Health Questionnaire, the Parenting Stress Index, and the Child Behaviour Checklist as part of a developmental follow-up protocol when their child was 5 years of age. Mean scores on the Child Health Questionnaire were in the normal range, with physical well-being equal to 53.5, psychosocial well-being 50.9, with only 6.4 percent and 8.5 percent of subjects, respectively, falling within the suboptimal range of less than 40. The distribution of scores on the Parenting Stress Index, however, were more variable, with over one-quarter of parents indicating a high level of stress, with almost one-fifth having low levels of stress, and just over half scoring in the normal range, with the group mean being 52.6 plus or minus 32.3. An abnormal neurologic examination before surgery was associated with lower physical health (β equal to −5.5, p equal to 0.02, r2equal to 0.18), whereas lower arterial saturations of oxygen, less than 85 percent preoperatively, was associated with lower psychosocial health (β equal to −6.6, p equal to 0.01, and r2equal to 0.14). The internalizing and externalizing behaviours of the child were significantly correlated with psychosocial well being, with r ranging from −0.32 to −0.52, and p less than 0.05. Parental stress also correlated with psychosocial health (r equal to −0.48 and p equal to 0.0009). Overall, the perception by the parents of the health-related quality of life of their child is favourable 5 years following open-heart surgery during infancy. Many parents, nonetheless, continue to feel either stressed or defensive about their child, particularly if their child exhibits behavioural difficulties. Our findings suggest that strategies need to be considered to enhance family well-being in the planning and delivery of health services to this population at high risk.

Types of prayer, optimism, and well-being of middle-aged and older patients undergoing open-heart surgery

2008 ◽  
Vol 11 (1) ◽  
pp. 131-150 ◽  
Author(s):  
Amy L. Ai ◽  
Terrence N. Tice ◽  
Bu Huang ◽  
Willard Rodgers ◽  
Steven F. Bolling
Keyword(s):  
Older Patients ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Well Being ◽  
Open Heart ◽  
Middle Aged

Patterns and prognostic value of troponin, interleukin-6, and leptin after pediatric open-heart surgery

2009 ◽  
Vol 24 (3) ◽  
pp. 419-425 ◽  
Author(s):  
Dalit Modan-Moses ◽  
Anat Prince ◽  
Hannah Kanety ◽  
Clara Pariente ◽  
Ovdi Dagan ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Prognostic Value ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart

Effect of steroids on inflammatory markers and clinical parameters in congenital open heart surgery: a randomised controlled trial

2015 ◽  
Vol 26 (3) ◽  
pp. 506-515 ◽  
Author(s):  
Muhammad M. Amanullah ◽  
Mohammad Hamid ◽  
Hashim M. Hanif ◽  
Marium Muzaffar ◽  
Maria T. Siddiqui ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Interleukin 6 ◽  
Heart Surgery ◽  
Controlled Trial ◽  
Open Heart Surgery ◽  
Interleukin 10 ◽  
Clinical Parameters ◽  
Open Heart ◽  
Necrosis Factor Alpha ◽  
Randomised Controlled

AbstractBackgroundCardiopulmonary bypass is associated with systemic inflammatory response. Steroids suppress this response, although the therapeutic evidence remains controversial. We hypothesised that intravenous steroids in children undergoing open-heart surgery would decrease inflammation leading to better early post-operative outcomes. We conducted a randomised controlled trial to evaluate the trends in the levels of immunomodulators and their effects on clinical parameters.ObjectiveTo assess the effects of intravenous steroids on early post-operative inflammatory markers and clinical parameters in children undergoing open-heart surgery.Materials and methodsA randomised controlled trial involving 152 patients, from one month up to 18 years of age, who underwent open-heart surgery for congenital heart disease from April 2010–2012 was carried out. Patients were randomised and administered either three scheduled intravenous pulse doses of dexamethasone (1 mg/kg) or placebo. Blood samples were drawn at four time intervals and serum levels of inflammatory cytokines – Interleukin-6, 8, 10, 18, and tumour necrosis factor-alpha – were measured. Clinical parameters were also assessed.ResultsBlood cytokine levels were compared between the dexamethasone (n=65) and placebo (n=64) groups. Interleukin-6 levels were lower at 6 and 24 hours post-operatively (p<0.001), and Interleukin-10 levels were higher 6 hours post-operatively (p<0.001) in the steroid group. Interleukin-8, 18, and tumour necrosis factor-alpha levels did not differ between the groups at any time intervals. The clinical parameters were similar in both the groups.ConclusionDexamethasone caused quantitative suppression of Interleukin-6 and increased Interleukin-10 activation, contributing to reduced immunopathology, but it did not translate into clinical benefit in the short term.

scholarly journals Respiratory Fitness and Mental Health in Patients Who Had Undergoing Open Heart Surgery: A Preliminary Observational Study

2019 ◽  
Vol 13 (6) ◽  
pp. 363-368
Author(s):  
Kornanong Yuenyongchaiwat ◽  
Sasipa Buranapuntalug ◽  
Khajonsak Pongpanit ◽  
Chitima Kulchanarat
Keyword(s):  
Mental Health ◽  
Observational Study ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart

scholarly journals The effect of training coping styles to deal with negative emotions on mental health of patients undergoing open heart surgery

2016 ◽  
Vol 3 (4) ◽  
pp. 13-19
Author(s):  
Marzieh Mohammadi Pashaki ◽  
Abasali Mahmoodi Mollayi ◽  
Bahram Mirzayian ◽  
Jabar Heydari ◽  
Hedayat Jafari ◽  
...  
Keyword(s):  
Mental Health ◽  
Heart Surgery ◽  
Coping Styles ◽  
Negative Emotions ◽  
Open Heart Surgery ◽  
Open Heart

Depressed Mood Over Time after Open Heart Surgery Impacts Patient Well-Being: A Combined Study

2008 ◽  
Vol 7 (4) ◽  
pp. 277-283 ◽  
Author(s):  
Ann-Kristin Karlsson ◽  
Evy Lidell ◽  
Mats Johansson
Keyword(s):  
Depressed Mood ◽  
Heart Surgery ◽  
Qualitative Content Analysis ◽  
Open Heart Surgery ◽  
Transition Process ◽  
Well Being ◽  
Recovery Phase ◽  
Open Heart ◽  
Cardiac Events

Background: Depression is a common cause of decreased well-being after open heart surgery (OHS) and a risk factor for new cardiac events. Little is known about the long-term prevalence of depressive symptoms after OHS or their effect on well-being. The aim of this study was to explore the presence of depressed mood in patients during the recovery phase after open heart surgery as well as depressed mood and well-being 3 years later. Method: Eighty consecutively included patients completed a questionnaire about depressed mood at 5 weeks, 5 months and 3 years after OHS. A telephone interview took place after receipt of the third questionnaire to explore their well-being. Quantitative and qualitative data were analysed separately and thereafter together. Result: Depressed mood occurred in 52% of the patients during recovery or 3 years after OHS. The qualitative content analysis produced the theme of transition, which was based on three categories. Conclusion: Depressed mood was reported by the majority of patients during recovery after OHS and had a long-term effect on their well-being. OHS constituted a transition for all patients, but those with depressed mood had difficulty finishing the transition process and reorientating life.

Evaluation of Systemic Inflammatory Response in Cardiovascular Surgery via Interleukin-6, Interleukin-8, and Neopterin

2014 ◽  
Vol 17 (1) ◽  
pp. 13 ◽  
Author(s):  
Ihsan Sami Uyar ◽  
Suleyman Onal ◽  
Ayhan Uysal ◽  
Ugur Ozdemir ◽  
Oktay Burma ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Valve Replacement ◽  
Interleukin 6 ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Beating Heart ◽  
Systemic Inflammatory Response ◽  
The Other ◽  
Open Heart ◽  
Group 3

<p><b>Aim:</b> The aim of this study was to evaluate the serum levels of interleukin-6 (IL-6), IL-8, and neopterin as a sign of systemic inflammatory response syndrome after open-heart surgery. In this study, we evaluated the influences on the levels of IL-6, IL-8, and neopterin of coronary artery bypass grafting (CABG) and valve replacement surgeries with and without the use of extracorporeal circulation (ECC).</p><p><b>Materials and Methods:</b> This prospective study was performed in 30 patients. In this study, we evaluated patients who underwent valve replacement surgery (group 1, n = 10), CABG with ECC (group 2, n = 10), or CABG using the beating-heart technique (group 3, n = 10). With the Human Investigation Ethics Committee consent, blood samples were obtained from the patients before the surgery (T0) and after 1 hour (T1), 4 hours (T2), 24 hours (T3), and 48 hours (T4) of protamine injection. IL-6, IL-8, and neopterin levels were measured using commercial enzyme-linked immunosorbent assay kits.</p><p><b>Results:</b> The demographic data and preoperative and operative characteristics of the patients were similar. Neopterin IL-6 and IL-8 levels significantly increased first at the fourth hour after the surgery. When compared to the levels before the surgery, this increase was statistically significant. Unlike the other 2 groups of patients, those who experienced CABG with the beating-heart technique (group 3) had decreased neopterin levels at the first hour after the surgery, but this decrease was not statistically significant. Neopterin levels increased later in the OPCAB group, but these increased levels were not as high as the neopterin levels of groups 1 and 2. Neopterin reached maximum levels at the 24th hour and, unlike groups 1 and 2, in group started to decrease at the 48th.</p><p><b>Conclusions:</b> Complement activation, cytokine production, and related cellular responses are important factors during open-heart surgery. It is certain that ECC activates the complement systems, and activated complement proteins cause the production of several cytokines. In our study, neopterin levels in patients who underwent beating-heart method surgery were lower than those in the other groups, and these levels started to decrease at the 48th hour. These data suggest that the systemic inflammatory response was less activated in that patient group. The beating-heart method might be an important alternative in CABG surgery to minimize the complications and mortality related to surgery.</p>

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