P.4.038 The 5-HT1A receptor antagonist robalzotan facilitates passive avoidance retention in male mice: Possible mediation via increased cholinergic transmission

2003 ◽  
Vol 13 ◽  
pp. S401
Author(s):  
N. Madjid ◽  
F. Asadi-kanari ◽  
J. Sandin ◽  
S.O. Ögren
Keyword(s):  
Passive Avoidance ◽  
Receptor Antagonist ◽  
Cholinergic Transmission ◽  
Male Mice

scholarly journals Selective Glucocorticoid Receptor Antagonist CORT125281 Activates Brown Adipose Tissue and Alters Lipid Distribution in Male Mice

Endocrinology ◽  
2017 ◽  
Vol 159 (1) ◽  
pp. 535-546 ◽  
Author(s):  
Jan Kroon ◽  
Lisa L Koorneef ◽  
Jose K van den Heuvel ◽  
Cristy R C Verzijl ◽  
Nienke M van de Velde ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Glucocorticoid Receptor ◽  
Brown Adipose Tissue ◽  
Receptor Antagonist ◽  
Male Mice ◽  
Lipid Distribution ◽  
Brown Adipose

scholarly journals Effect of Donepezil on Group II mGlu Receptor Agonist- or Antagonist-Induced Amnesia on Passive Avoidance in Mice

2003 ◽  
Vol 10 (4) ◽  
pp. 319-325 ◽  
Author(s):  
Tomoaki Sato ◽  
Koh-ichi Tanaka ◽  
Yoshiko Ohnishi ◽  
Masahiro Irifune ◽  
Takashige Nishikawa
Keyword(s):  
Passive Avoidance ◽  
Receptor Antagonist ◽  
Receptor Agonist ◽  
Memory Performance ◽  
Memory Function ◽  
Avoidance Performance ◽  
Ache Inhibitor ◽  
Avoidance Task ◽  
Mglu Receptor ◽  
Group Ii

We examined the effect of the acetylcholinesterase (ACHE) inhibitor, donepezil hydrocloride (DONP), on group II metabotropic glutamate (mGlu) receptor agonist- or antagonist-induced amnesia in the step-through passive avoidance task in male mice. DCG-IV, a group II mGlu receptor agonist, at dose of 50 ng and LY341495, a group II mGlu receptor antagonist, at dose of 300 ng, significantly attenuated the latency on the step-through task. The subcutaneous injection of DONP at dose of 1 mg/kg 1 hour before passive avoidance performance ameliorated the amnesia induced by DCG-IV and LY341495, whereas donepezil alone did not affect task latency. The results suggest that activation of group II mGlu receptors and disinhibition of the cAMP/PKA signaling pathway (caused by group II mGlu receptor antagonist) have a negative action on step-through passive avoidance memory performance, and that group II mGlu receptors and ACh interact to modulate learning and memory function.

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