P.3.a.015 Relation between working memory and negative symptoms and other factors in patients with first episode of schizophrenia

Abstract Since working memory deficits in schizophrenia have been linked to negative symptoms, we tested whether features of the one could predict the treatment outcome in the other. Specifically, we hypothesized that working memory-related functional connectivity at pre-treatment can predict improvement of negative symptoms in antipsychotic-treated patients. Fourteen antipsychotic-naive patients with first-episode schizophrenia were clinically assessed before and after 7 months of quetiapine monotherapy. At baseline, patients underwent functional magnetic resonance imaging while performing a verbal n-back task. Spatial independent component analysis identified task-modulated brain networks. A linear support vector machine was trained with these components to discriminate six patients who showed improvement in negative symptoms from eight non-improvers. Classification accuracy and significance was estimated by leave-one-out cross-validation and permutation tests, respectively. Two frontoparietal and one default mode network components predicted negative symptom improvement with a classification accuracy of 79% (p = 0.003). Discriminating features were found in the frontoparietal networks but not the default mode network. These preliminary data suggest that functional patterns at baseline can predict negative symptom treatment–response in schizophrenia. This information may be used to stratify patients into subgroups thereby facilitating personalized treatment.

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Treatment of the patient with long-term schizophrenia

Advances in Psychiatric Treatment ◽

10.1192/apt.3.6.339 ◽

1997 ◽

Vol 3 (6) ◽

pp. 339-346 ◽

Cited By ~ 2

Author(s):

Ann Mortimer

Keyword(s):

Negative Symptoms ◽

Chronic Illnesses ◽

First Episode ◽

Positive Symptoms ◽

Loss Of Self ◽

Appropriate Treatment ◽

Community Skills ◽

First Episode Of Schizophrenia ◽

Over Time

At most, 15% of patients in Western countries remain free of relapse after their first episode of schizophrenia (Crow et al, 1986). Like many chronic illnesses, schizophrenia can be controlled by appropriate treatment, but there may be a gradual deterioration over time. This encompasses problems such as loss of self-care, communication and community skills; negative symptoms of poverty of affect and ideation; cognitive impairment; behaviour problems such as aggression; and poorly controlled positive symptoms.

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Abnormality of working memory of patients with first-episode of schizophrenia. Working memory functions are active for only a short period of time

PsycEXTRA Dataset ◽

10.1037/e516032012-109 ◽

2004 ◽

Author(s):

V. Mangubi

Keyword(s):

Working Memory ◽

First Episode ◽

Memory Functions ◽

Short Period ◽

First Episode Of Schizophrenia

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Spatial working memory deficits in first-episode psychosis: Relationship with negative symptoms

Schizophrenia Research ◽

10.1016/s0920-9964(03)80962-3 ◽

2003 ◽

Vol 60 (1) ◽

pp. 146

Author(s):

M.A. McConchie ◽

T.M. Proffitt ◽

R. Monfries ◽

S.J. Wood ◽

W.J. Brewer ◽

...

Keyword(s):

Working Memory ◽

Negative Symptoms ◽

Spatial Working Memory ◽

Memory Deficits ◽

First Episode Psychosis ◽

First Episode ◽

Episode Psychosis

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Characteristics of Outcome in Schizophrenia at 13 Years

The British Journal of Psychiatry ◽

10.1192/bjp.167.5.596 ◽

1995 ◽

Vol 167 (5) ◽

pp. 596-603 ◽

Cited By ~ 96

Author(s):

Peter Mason ◽

Glynn Harrison ◽

Cristine Glazebrook ◽

Ian Medley ◽

Tim Dalkin ◽

...

Keyword(s):

Negative Symptoms ◽

Psychotic Symptoms ◽

First Episode ◽

Follow Up Studies ◽

Long Term Follow Up ◽

Lost To Follow Up ◽

Representative Cohort ◽

First Episode Of Schizophrenia

BackgroundThis paper describes the 13-year outcome of an epidemiologically defined and representative cohort of patients selected when they were experiencing their first episode of schizophrenia.MethodIn a 13-year follow-up study of a cohort identified in Nottingham in 1978–80, the outcome (symptoms, disability, residence and treatment) was assessed using standardised instruments.ResultsFour of the original 67 patients with ICD–9 schizophrenia were lost to follow-up and five were dead: 52% were without psychotic symptoms in the last two years of follow-up, 52% were without negative symptoms and 55% showed good/fair social functioning. However, only 17% were alive at follow-up, without symptoms and disability, and receiving no treatment.ConclusionsThe findings reported are similar to those of other long-term follow-up studies of schizophrenia and also to 5-year follow-up studies. Kraepelin's emphasis on the longitudinal implications of a diagnosis of schizophrenia are supported, but may be over-pessimistic.

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PLASMA HOMOVANILLIC ACID LEVELS DURING THE FIRST-YEAR AFTER THE DIAGNOSIS OF A FIRST EPISODE OF SCHIZOPHRENIA: ASSOCIATION WITH NEGATIVE SYMPTOMS

Schizophrenia Research ◽

10.1016/j.schres.2010.02.389 ◽

2010 ◽

Vol 117 (2-3) ◽

pp. 251

Author(s):

Inmaculada Baeza ◽

Elena de la Serna ◽

Ramon Deulofeu ◽

Javier Goti ◽

Miquel Bernardo ◽

...

Keyword(s):

Homovanillic Acid ◽

Negative Symptoms ◽

First Episode ◽

First Year ◽

First Episode Of Schizophrenia

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Impaired cue identification and intention retrieval underlie prospective memory deficits in patients with first-episode schizophrenia

Australian & New Zealand Journal of Psychiatry ◽

10.1177/0004867416640097 ◽

2016 ◽

Vol 51 (3) ◽

pp. 270-277 ◽

Cited By ~ 6

Author(s):

Dengtang Liu ◽

Chengfeng Ji ◽

Kaiming Zhuo ◽

Zhenhua Song ◽

Yingchan Wang ◽

...

Keyword(s):

Working Memory ◽

Prospective Memory ◽

Effect Size ◽

Negative Symptoms ◽

First Episode ◽

Healthy Controls ◽

Retrospective Memory ◽

The Difference ◽

Event Based ◽

First Episode Schizophrenia

Objective: Schizophrenia is associated with impairment in prospective memory, the ability to remember to carry out an intended action in the future. It has been established that cue identification (detection of the cue event signaling that an intended action should be performed) and intention retrieval (retrieval of an intention from long-term memory following the recognition of a prospective cue) are two important processes underlying prospective memory. The purpose of this study was to examine prospective memory deficit and underlying cognitive processes in patients with first-episode schizophrenia. Methods: This study examined cue identification and intention retrieval components of event-based prospective memory using a dual-task paradigm in 30 patients with first-episode schizophrenia and 30 healthy controls. All participants were also administered a set of tests assessing working memory and retrospective memory. Results: Both cue identification and intention retrieval were impaired in patients with first-episode schizophrenia compared with healthy controls ( ps < 0.05), with a large effect size for cue identification (Cohen’s d = 0.98) and a medium effect size for intention retrieval (Cohen’s d = 0.62). After controlling for working memory and retrospective memory, the difference in cue identification between patients and healthy controls remained significant. However, the difference in intention retrieval between the two groups was no longer significant. In addition, there was a significant inverse relationship between cue identification and negative symptoms ( r = −0.446, p = 0.013) in the patient group. Conclusion: These findings suggest that both cue identification and intention retrieval in event-based prospective memory are impaired in patients with first-episode schizophrenia. Cue identification and intention retrieval could be potentially used as biomarkers for early detection and treatment prognosis of schizophrenia. In addition, addressing cue identification deficit through cognitive enhancement training may potentially improve negative symptoms as well.

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Poster #S169 VERBAL MEMORY, BUT NOT WORKING MEMORY AS COGNITIVE MARKER OF NEGATIVE SYMPTOMS IN PATIENTS WITH FIRST EPISODE OF PSYCHOSIS

Schizophrenia Research ◽

10.1016/s0920-9964(14)70448-7 ◽

2014 ◽

Vol 153 ◽

pp. S150

Author(s):

Gisela Mezquida ◽

Bibiana Cabrera ◽

Miquel Bioque ◽

Clemente García-Rizo ◽

Cristina Oliveira ◽

...

Keyword(s):

Working Memory ◽

Verbal Memory ◽

Negative Symptoms ◽

First Episode

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Prevalence and clinical correlates of depression in the acute phase of first episode schizophrenia

Irish Journal of Psychological Medicine ◽

10.1017/s0790966700000860 ◽

2010 ◽

Vol 27 (1) ◽

pp. 15-18 ◽

Cited By ~ 7

Author(s):

Eric Roche ◽

Mary Clarke ◽

Stephen Browne ◽

Niall Turner ◽

Orflaith McTuige ◽

...

Keyword(s):

Negative Symptoms ◽

Depression Scale ◽

First Episode ◽

Syndrome Scale ◽

Prevalence Of Depression ◽

History Of ◽

First Episode Schizophrenia ◽

Negative Syndrome ◽

First Episode Of Schizophrenia

AbstractBackground: Reported rates of depression in schizophrenia vary considerably.Objective: To measure the prevalence of depression in a first episode sample of people with schizophrenia.Methods: All referrals with a first episode of schizophrenia diagnosed using SCID interviews were assessed pre-discharge and again six months later. We used the Calgary Depression Scale for Schizophrenia (CDSS) and Positive and Negative Syndrome Scale (PANSS) to assess the severity of symptoms.Results: Pre-discharge, 10.4% of the sample met CDSS criteria for depression. According to the PANSS depression (PANSS -D) subscale, 3% of patients were depressed, with a mean score of 7.48 (SD = 2.97). Only 3% of patients pre-discharge were found to be depressed on both the CDSS and the PANSS-D. Six months later 6.5% were depressed according to the CDSS. However none reached depression criteria according to the PANSS-D. The CDSS correlated with PANSS-D both pre-discharge and at follow-up. Feelings of depression and self-deprecation were the most common symptoms at baseline and follow-up. The CDSS was unrelated to negative symptoms at both stages. A lifetime history of alcohol abuse increased the risk for depression.Conclusion: Rates of depression in this sample were low. The CDSS appears to discriminate between depression and negative symptoms. Like the general population, alcohol misuse is a risk factor for depression in first episode schizophrenia.

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