Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications

2004 ◽  
Vol 57 (1) ◽  
pp. 19-34 ◽  
Author(s):  
J. Berger ◽  
M. Reist ◽  
J.M. Mayer ◽  
O. Felt ◽  
N.A. Peppas ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Crosslinked Chitosan ◽  
Chitosan Hydrogels

scholarly journals Tuneable Thiol-Ene Photo-Crosslinked Chitosan-Based Hydrogels for Biomedical Applications

2020 ◽  
Author(s):  
Sarah michel ◽  
Sarah E rogers ◽  
Wuge H. Briscoe ◽  
M. Carmen Galan
Keyword(s):  
Cell Adhesion ◽  
Small Molecules ◽  
Biomedical Applications ◽  
Polymer Concentration ◽  
Swelling Ratio ◽  
Practical Synthesis ◽  
Crosslinked Chitosan ◽  
Chitosan Hydrogels ◽  
Potential Use

<p>Access to biocompatible hydrogels with tuneable properties is of great interest. Here we report the practical synthesis and characterisation of a series of photo-crosslinked chitosan hydrogels from norbornene-functionalised chitosan (CS-nb) and various thiolated crosslinkers. The resulting materials were characterised by NMR, swelling ratio, rheology, SEM and SANS. The new hydrogels exhibit pH- and salt-dependent swelling whilst the macro- and microscale properties can be modulated by the choice and degree of crosslinker or the polymer concentration. The materials can be molded <i>in situ </i>and loaded with small molecules that are released overtime. Moreover, the incorporation of collagen in the hydrogels drastically improves cell adhesion and excellent cell viabilities were observed with human dermofibroblast cells for up to 6 days, highlighting the potential use of these materials in the biomedical area.</p>

scholarly journals Tuneable Thiol-Ene Photo-Crosslinked Chitosan-Based Hydrogels for Biomedical Applications

2020 ◽  
Author(s):  
Sarah michel ◽  
Sarah E rogers ◽  
Wuge H. Briscoe ◽  
M. Carmen Galan
Keyword(s):  
Cell Adhesion ◽  
Small Molecules ◽  
Biomedical Applications ◽  
Polymer Concentration ◽  
Swelling Ratio ◽  
Practical Synthesis ◽  
Crosslinked Chitosan ◽  
Chitosan Hydrogels ◽  
Potential Use

<p>Access to biocompatible hydrogels with tuneable properties is of great interest. Here we report the practical synthesis and characterisation of a series of photo-crosslinked chitosan hydrogels from norbornene-functionalised chitosan (CS-nb) and various thiolated crosslinkers. The resulting materials were characterised by NMR, swelling ratio, rheology, SEM and SANS. The new hydrogels exhibit pH- and salt-dependent swelling whilst the macro- and microscale properties can be modulated by the choice and degree of crosslinker or the polymer concentration. The materials can be molded <i>in situ </i>and loaded with small molecules that are released overtime. Moreover, the incorporation of collagen in the hydrogels drastically improves cell adhesion and excellent cell viabilities were observed with human dermofibroblast cells for up to 6 days, highlighting the potential use of these materials in the biomedical area.</p>

Chitosan hydrogels in 3D printing for biomedical applications

2021 ◽  
Vol 260 ◽  
pp. 117768
Author(s):  
Mina Rajabi ◽  
Michelle McConnell ◽  
Jaydee Cabral ◽  
M. Azam Ali
Keyword(s):  
3D Printing ◽  
Biomedical Applications ◽  
Chitosan Hydrogels

Formaldehyde and tripolyphosphate crosslinked chitosan hydrogels: Synthesis, characterization and modeling

2021 ◽  
Vol 183 ◽  
pp. 2293-2304
Author(s):  
Nahum Andrés Medellín-Castillo ◽  
Elizabeth Diane Isaacs-Páez ◽  
Itzia Rodríguez-Méndez ◽  
Raul González-García ◽  
Gladis Judith Labrada-Delgado ◽  
...  
Keyword(s):  
Crosslinked Chitosan ◽  
Chitosan Hydrogels

Terephthalaldehyde as better crosslinking agent in crosslinked chitosan hydrogel for selective removal of anionic dyes

2021 ◽  
Author(s):  
Madhvi Garg ◽  
Navneet Bhullar ◽  
Bharat Bajaj ◽  
Dhiraj Sud
Keyword(s):  
Crosslinking Agent ◽  
Selective Removal ◽  
Synthetic Dyes ◽  
Anionic Dyes ◽  
Chitosan Hydrogel ◽  
Ultrasound Radiation ◽  
Radiation Induced ◽  
Crosslinked Chitosan ◽  
Chitosan Hydrogels ◽  
Crosslinking Agents

The present manuscript reports the ultrasound radiation induced synthesis of grafted chitosan hydrogels (CAAT and CAAG) using terephthalaldehyde/glutaraldehyde as crosslinking agents and its application for removal of synthetic dyes from...

scholarly journals Comparison of Rheological, Drug Release, and Mucoadhesive Characteristics upon Storage between Hydrogels with Unmodified or Beta-Glycerophosphate-Crosslinked Chitosan

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Emilia Szymańska ◽  
Anna Czajkowska-Kośnik ◽  
Katarzyna Winnicka
Keyword(s):  
Drug Release ◽  
Ex Vivo ◽  
Physicochemical Characteristics ◽  
Vaginal Mucosa ◽  
Drug Release Profile ◽  
Modified Chitosan ◽  
Long Term Storage ◽  
Crosslinked Chitosan ◽  
Chitosan Hydrogels ◽  
The Impact

The physicochemical characteristics of beta-glycerophosphate-crosslinked chitosan hydrogels were investigated upon long-term storage at ambient, accelerated, and refrigerated conditions and compared to unmodified chitosan formulations. Additionally, the impact of chitosan modification on the ex vivo mucoadhesive performance in contact with porcine vaginal mucosa and on the drug release profile from hydrogels was evaluated. Viscosity and mechanical properties of formulations with unmodified chitosan decreased significantly upon storage regardless of tested conditions as a result of hydrolytic depolymerization. Introduction of ion crosslinker exerted stabilizing effect on physicochemical performance of chitosan hydrogels but only upon storage at refrigerated conditions. Beta-glycerophosphate-modified chitosan formulations preserved organoleptic, rheological behavior, and hydrogel structure up to 3-month storage at 4 ± 2°C. Viscosity variations upon storage influenced markedly mucoadhesive properties and drug release rate from hydrogels.

scholarly journals Correction: Non-thermal plasma assisted surface nano-textured carboxymethyl guar gum/chitosan hydrogels for biomedical applications

RSC Advances ◽  
2019 ◽  
Vol 9 (62) ◽  
pp. 36285-36286
Author(s):  
Ganeswar Dalei ◽  
Subhraseema Das ◽  
Smruti Prava Das
Keyword(s):  
Thermal Plasma ◽  
Biomedical Applications ◽  
Guar Gum ◽  
Non Thermal Plasma ◽  
Chitosan Hydrogels

Correction for ‘Non-thermal plasma assisted surface nano-textured carboxymethyl guar gum/chitosan hydrogels for biomedical applications’ by Ganeswar Dalei et al., RSC Adv., 2019, 9, 1705–1716.

scholarly journals Cu+-containing physically crosslinked chitosan hydrogels with shape memory

2019 ◽  
Vol 13 (9) ◽  
pp. 785-793 ◽  
Author(s):  
Z. Y. Yu ◽  
Y. Li ◽  
Z. P. Feng ◽  
Z. H. Zhang ◽  
P. Li ◽  
...  
Keyword(s):  
Shape Memory ◽  
Crosslinked Chitosan ◽  
Physically Crosslinked ◽  
Chitosan Hydrogels
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