scholarly journals Tuneable Thiol-Ene Photo-Crosslinked Chitosan-Based Hydrogels for Biomedical Applications

2020 ◽  
Author(s):  
Sarah michel ◽  
Sarah E rogers ◽  
Wuge H. Briscoe ◽  
M. Carmen Galan
Keyword(s):  
Cell Adhesion ◽  
Small Molecules ◽  
Biomedical Applications ◽  
Polymer Concentration ◽  
Swelling Ratio ◽  
Practical Synthesis ◽  
Crosslinked Chitosan ◽  
Chitosan Hydrogels ◽  
Potential Use

<p>Access to biocompatible hydrogels with tuneable properties is of great interest. Here we report the practical synthesis and characterisation of a series of photo-crosslinked chitosan hydrogels from norbornene-functionalised chitosan (CS-nb) and various thiolated crosslinkers. The resulting materials were characterised by NMR, swelling ratio, rheology, SEM and SANS. The new hydrogels exhibit pH- and salt-dependent swelling whilst the macro- and microscale properties can be modulated by the choice and degree of crosslinker or the polymer concentration. The materials can be molded <i>in situ </i>and loaded with small molecules that are released overtime. Moreover, the incorporation of collagen in the hydrogels drastically improves cell adhesion and excellent cell viabilities were observed with human dermofibroblast cells for up to 6 days, highlighting the potential use of these materials in the biomedical area.</p>

scholarly journals Tuneable Thiol-Ene Photo-Crosslinked Chitosan-Based Hydrogels for Biomedical Applications

2020 ◽  
Author(s):  
Sarah michel ◽  
Sarah E rogers ◽  
Wuge H. Briscoe ◽  
M. Carmen Galan
Keyword(s):  
Cell Adhesion ◽  
Small Molecules ◽  
Biomedical Applications ◽  
Polymer Concentration ◽  
Swelling Ratio ◽  
Practical Synthesis ◽  
Crosslinked Chitosan ◽  
Chitosan Hydrogels ◽  
Potential Use

<p>Access to biocompatible hydrogels with tuneable properties is of great interest. Here we report the practical synthesis and characterisation of a series of photo-crosslinked chitosan hydrogels from norbornene-functionalised chitosan (CS-nb) and various thiolated crosslinkers. The resulting materials were characterised by NMR, swelling ratio, rheology, SEM and SANS. The new hydrogels exhibit pH- and salt-dependent swelling whilst the macro- and microscale properties can be modulated by the choice and degree of crosslinker or the polymer concentration. The materials can be molded <i>in situ </i>and loaded with small molecules that are released overtime. Moreover, the incorporation of collagen in the hydrogels drastically improves cell adhesion and excellent cell viabilities were observed with human dermofibroblast cells for up to 6 days, highlighting the potential use of these materials in the biomedical area.</p>

scholarly journals Biocomposites Based on Biogenous Mineral for Inducing Biomimetic Mineralization

2017 ◽  
Vol 54 (2) ◽  
pp. 207-213
Author(s):  
Diana Maria Dragusin ◽  
Filis Curti ◽  
Sergiu Cecoltan ◽  
Daniela Sarghiuta ◽  
Livia Maria Butac ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Bone Substitute ◽  
Biomedical Applications ◽  
Biomimetic Mineralization ◽  
Bone Powder ◽  
Bovine Gelatin

In this work, we focused on the potential of biogenous mineral from Cuttlefish bone for inducing biomimetic mineralization with further biomedical applications. We demonstrate the formation of strong and flexible hydrogels via physical immobilization of cuttlefish bone powder in the presence of bovine gelatin and alginate. The properties of hydrogels loaded with biogenous mineral, with a commercial bone substitute, with commercial nano-hydroxyapatite and in situ generated hydroxyapatite. In vitro cell adhesion tests demonstrated that the new developed hydrogels showed a promising cell adhesion.

An atomic-resolution microscope study of Al contracts on GaAs

1986 ◽  
Vol 44 ◽  
pp. 726-727
Author(s):  
Z. Liliental-Weber ◽  
C. Nelson ◽  
R. Ludeke ◽  
R. Gronsky ◽  
J. Washburn
Keyword(s):  
High Speed ◽  
Schottky Contacts ◽  
Detailed Knowledge ◽  
The Past ◽  
Semiconductor Interfaces ◽  
Deposited Metal ◽  
Microwave Applications ◽  
Free Interfaces ◽  
Potential Use

The properties of metal/semiconductor interfaces have received considerable attention over the past few years, and the Al/GaAs system is of special interest because of its potential use in high-speed logic integrated optics, and microwave applications. For such materials a detailed knowledge of the geometric and electronic structure of the interface is fundamental to an understanding of the electrical properties of the contact. It is well known that the properties of Schottky contacts are established within a few atomic layers of the deposited metal. Therefore surface contamination can play a significant role. A method for fabricating contamination-free interfaces is absolutely necessary for reproducible properties, and molecularbeam epitaxy (MBE) offers such advantages for in-situ metal deposition under UHV conditions

Conjugates of Classical DNA/RNA Binder with Nucleobase: Chemical, Biochemical and Biomedical Applications

2019 ◽  
Vol 26 (30) ◽  
pp. 5609-5624
Author(s):  
Dijana Saftić ◽  
Željka Ban ◽  
Josipa Matić ◽  
Lidija-Marija Tumirv ◽  
Ivo Piantanida
Keyword(s):  
Molecular Weight ◽  
Small Molecules ◽  
Biomedical Applications ◽  
Protein Targets ◽  
New Class ◽  
Rna Targets ◽  
Covalently Linked ◽  
Structural Aspects

: Among the most intensively studied classes of small molecules (molecular weight < 650) in biomedical research are small molecules that non-covalently bind to DNA/RNA, and another intensively studied class is nucleobase derivatives. Both classes have been intensively elaborated in many books and reviews. However, conjugates consisting of DNA/RNA binder covalently linked to nucleobase are much less studied and have not been reviewed in the last two decades. Therefore, this review summarized reports on the design of classical DNA/RNA binder – nucleobase conjugates, as well as data about their interactions with various DNA or RNA targets, and even in some cases protein targets are involved. According to these data, the most important structural aspects of selective or even specific recognition between small molecule and target are proposed, and where possible related biochemical and biomedical aspects were discussed. The general conclusion is that this, rather new class of molecules showed an amazing set of recognition tools for numerous DNA or RNA targets in the last two decades, as well as few intriguing in vitro and in vivo selectivities. Several lead research lines show promising advancements toward either novel, highly selective markers or bioactive, potentially druggable molecules.

Chitosan hydrogels in 3D printing for biomedical applications

2021 ◽  
Vol 260 ◽  
pp. 117768
Author(s):  
Mina Rajabi ◽  
Michelle McConnell ◽  
Jaydee Cabral ◽  
M. Azam Ali
Keyword(s):  
3D Printing ◽  
Biomedical Applications ◽  
Chitosan Hydrogels

Formaldehyde and tripolyphosphate crosslinked chitosan hydrogels: Synthesis, characterization and modeling

2021 ◽  
Vol 183 ◽  
pp. 2293-2304
Author(s):  
Nahum Andrés Medellín-Castillo ◽  
Elizabeth Diane Isaacs-Páez ◽  
Itzia Rodríguez-Méndez ◽  
Raul González-García ◽  
Gladis Judith Labrada-Delgado ◽  
...  
Keyword(s):  
Crosslinked Chitosan ◽  
Chitosan Hydrogels

Terephthalaldehyde as better crosslinking agent in crosslinked chitosan hydrogel for selective removal of anionic dyes

2021 ◽  
Author(s):  
Madhvi Garg ◽  
Navneet Bhullar ◽  
Bharat Bajaj ◽  
Dhiraj Sud
Keyword(s):  
Crosslinking Agent ◽  
Selective Removal ◽  
Synthetic Dyes ◽  
Anionic Dyes ◽  
Chitosan Hydrogel ◽  
Ultrasound Radiation ◽  
Radiation Induced ◽  
Crosslinked Chitosan ◽  
Chitosan Hydrogels ◽  
Crosslinking Agents

The present manuscript reports the ultrasound radiation induced synthesis of grafted chitosan hydrogels (CAAT and CAAG) using terephthalaldehyde/glutaraldehyde as crosslinking agents and its application for removal of synthetic dyes from...

scholarly journals Performance of a Handheld Chlorophyll-a Fluorometer: Potential Use for Rapid Algae Monitoring

Water ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1409
Author(s):  
Hamdhani Hamdhani ◽  
Drew E. Eppehimer ◽  
David Walker ◽  
Michael T. Bogan
Keyword(s):  
Chlorophyll A ◽  
Surface Waters ◽  
Harmful Algal Blooms ◽  
Algal Blooms ◽  
Water Quality Monitoring ◽  
Ambient Light ◽  
Calibration Equation ◽  
Field Samples ◽  
Potential Use

Chlorophyll-a measurements are an important factor in the water quality monitoring of surface waters, especially for determining the trophic status and ecosystem management. However, a collection of field samples for extractive analysis in a laboratory may not fully represent the field conditions. Handheld fluorometers that can measure chlorophyll-a in situ are available, but their performance in waters with a variety of potential light-interfering substances has not yet been tested. We tested a handheld fluorometer for sensitivity to ambient light and turbidity and compared these findings with EPA Method 445.0 using water samples obtained from two urban lakes in Tucson, Arizona, USA. Our results suggested that the probe was not sensitive to ambient light and performed well at low chlorophyll-a concentrations (<25 µg/L) across a range of turbidity levels (50–70 NTU). However, the performance was lower when the chlorophyll-a concentrations were >25 µg/L and turbidity levels were <50 NTU. To account for this discrepancy, we developed a calibration equation to use for this handheld fluorometer when field monitoring for potential harmful algal blooms in water bodies.

Anodic synthesis of TiO2 nanotubes by step-up voltages

2021 ◽  
pp. 002199832110237
Author(s):  
V Sivaprakash ◽  
R Narayanan
Keyword(s):  
Corrosion Resistance ◽  
Tio2 Nanotubes ◽  
Biomedical Applications ◽  
Phase Changes ◽  
Electrochemical Anodization ◽  
Corrosion Resistant ◽  
Anodization Process ◽  
Anodic Synthesis ◽  
Input Potential

Fabrication of TiO2 nanotubes (NTs) has extensive application properties due to their high corrosion resistant and compatibility with biomedical applications, the synthesis of TiO2 nanotubes over titanium has drawn interest in various fields. The synthesis of TiO2 NTs using novel in-situ step-up voltage conditions in the electrochemical anodization process is recorded in this work. For manufacturing the NTs at 1 hour of anodization, the input potential of 30, 40 and 50 V was selected. With increasing step-up voltage during the anodization process, an improvement in the NTs was observed, favoring corrosion resistance properties. The surface of NTs enhances the structure of the ribs, raising the potential for feedback over time. XRD was used to analyze phase changes, and HR-SEM analyzed surface topography. Impedance tests found that longer NTs improved the corrosion resistance.

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