Optimization of an effervescent tablet formulation using a central composite design optimization of an effervescent tablet formulation containing spray dried l-leucine and polyethylene glycol 6000 as lubricants using a central composite design

1998 ◽  
Vol 46 (1) ◽  
pp. 85-94 ◽  
Author(s):  
Bärbel Rotthäuser ◽  
Gerolf Kraus ◽  
Peter C Schmidt
Keyword(s):  
Polyethylene Glycol ◽  
Central Composite Design ◽  
Design Optimization ◽  
Tablet Formulation ◽  
Effervescent Tablet ◽  
Polyethylene Glycol 6000 ◽  
Central Composite ◽  
Spray Dried

Central composite designed solid dispersion for dissolution enhancement of fluvastatin sodium by kneading technique

2020 ◽  
Vol 11 (5) ◽  
pp. 313-328
Author(s):  
Sukhbir Singh ◽  
Neelam Sharma ◽  
Gurpreet Kaur
Keyword(s):  
Polyethylene Glycol ◽  
Drug Release ◽  
Central Composite Design ◽  
Solid Dispersion ◽  
Aqueous Solubility ◽  
Dissolution Enhancement ◽  
Saturation Solubility ◽  
Polyethylene Glycol 6000 ◽  
Central Composite

Aim: This research is focused on enhancing aqueous solubility and dissolution of fluvastatin sodium (FSS) through solid dispersion (FSS-SD) production using polyethylene glycol 6000 and polyvinyl pyrollidone K-30 by kneading technique. Methodology & results: Central composite design explored the influence of polyethylene glycol 6000 and polyvinyl pyrollidone K-30 on T50% and Q90. The aqueous saturation solubility of FSS (8.7 ± 1.12 μg/ml) was amplified 20-fold in FSS-SD (179 ± 4.16 μg/ml). Cumulative drug release from FSS and optimized FSS-SD were 27.49 and 87.4% within 90 min, respectively. Conclusion: FSS-SD production using kneading technique offers great prospective in maximizing FSS's solubility and dissolution.

Central Composite Design Optimization of Biological Dye Removal in the Presence of Macroalgae Chara sp.

2010 ◽  
Vol 38 (8) ◽  
pp. 750-757 ◽  
Author(s):  
Ali R. Khataee ◽  
Gholamreza Dehghan ◽  
Elahe Ebadi ◽  
Minoo Pourhassan
Keyword(s):  
Central Composite Design ◽  
Design Optimization ◽  
Dye Removal ◽  
Central Composite

Simultaneous ultrasonic-assisted removal of malachite green and safranin O by copper nanowires loaded on activated carbon: central composite design optimization

RSC Advances ◽  
2015 ◽  
Vol 5 (70) ◽  
pp. 57021-57029 ◽  
Author(s):  
Mostafa Roosta ◽  
Mehrorang Ghaedi ◽  
Arash Asfaram
Keyword(s):  
Activated Carbon ◽  
Aqueous Solutions ◽  
Central Composite Design ◽  
Design Optimization ◽  
Malachite Green ◽  
Copper Nanowires ◽  
Ultrasonic Assisted ◽  
Ultrasound Assisted ◽  
Safranin O ◽  
Central Composite

The present study investigates the simultaneous ultrasound-assisted adsorption of malachite green (MG) and safranin O (SO) dyes from aqueous solutions by ultrasound-assisted adsorption onto copper nanowires loaded on activated carbon (Cu-NWs-AC).

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