Specific RGTA increases collagen V expression by cultured aortic smooth muscle cells via activation and protection of transforming growth factor-β1

2001 ◽  
Vol 20 (3) ◽  
pp. 171-181 ◽  
Author(s):  
Patricia Mestries ◽  
Catherine Alexakis ◽  
Dulce Papy-Garcia ◽  
Arlette Duchesnay ◽  
Denis Barritault ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Growth Factor ◽  
Smooth Muscle Cells ◽  
Transforming Growth Factor ◽  
Muscle Cells ◽  
Transforming Growth Factor Β1 ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle

scholarly journals Transforming growth factor-β1 increases lysyl oxidase enzyme activity and mRNA in rat aortic smooth muscle cells

1997 ◽  
Vol 25 (3) ◽  
pp. 446-452 ◽  
Author(s):  
Charles J. Shanley ◽  
Mehrnaz Gharaee-Kermani ◽  
Rajabrata Sarkar ◽  
Theodore H. Welling ◽  
Andrew Kriegel ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Smooth Muscle ◽  
Growth Factor ◽  
Smooth Muscle Cells ◽  
Transforming Growth Factor ◽  
Lysyl Oxidase ◽  
Muscle Cells ◽  
Transforming Growth Factor Β1 ◽  
Aortic Smooth Muscle ◽  
Oxidase Enzyme

scholarly journals Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells.

1986 ◽  
Vol 102 (4) ◽  
pp. 1217-1223 ◽  
Author(s):  
R K Assoian ◽  
M B Sporn
Keyword(s):  
Smooth Muscle ◽  
Growth Factor ◽  
Smooth Muscle Cells ◽  
Transforming Growth Factor ◽  
Primary Cultures ◽  
Muscle Cells ◽  
Human Platelets ◽  
Tgf Beta ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle

A specific radioimmunoassay for type beta transforming growth factor (TGF-beta) was developed and used to show that human platelets treated with thrombin release TGF-beta as a consequence of degranulation. The thrombin concentrations required to induce release of TGF-beta parallel those concentrations that release the alpha-granule marker, beta-thromboglobulin. Related studies showed that TGF-beta acts on early passage, explant cultures of bovine aortic smooth muscle cells by inhibiting the effect of mitogens on proliferation of subconfluent cell monolayers yet synergizing with mitogens to stimulate growth of the same cells when cultured in soft agar. The results show that primary cultures of bovine aortic smooth muscle cells and established normal rat kidney cells behave similarly with regard to TGF-beta action. Moreover, the data suggest that platelet-mediated proliferation of aortic smooth muscle cells in vivo may not result solely from the stimulatory effect of platelet-derived growth factor (PDGF), but rather from an interaction of platelet factors which has the intrinsic ability to limit as well as stimulate mitosis.

scholarly journals Transforming growth factor-β1elicits Nrf2-mediated antioxidant responses in aortic smooth muscle cells

2009 ◽  
Vol 13 (8b) ◽  
pp. 2282-2292 ◽  
Author(s):  
Adrian T. Churchman ◽  
Anila A. Anwar ◽  
Francois Y.L. Li ◽  
Hideyo Sato ◽  
Tetsuro Ishii ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Growth Factor ◽  
Smooth Muscle Cells ◽  
Transforming Growth Factor ◽  
Muscle Cells ◽  
Antioxidant Responses ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle
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