Chemoenzymatic synthesis of asymmetrized bis(hydroxymethyl)propanoates (BHYMP∗) as a new family of chiral building blocks

1997 ◽  
Vol 8 (24) ◽  
pp. 4079-4088 ◽  
Author(s):  
Luca Banfi ◽  
Andrea Basso ◽  
Giuseppe Guanti ◽  
Maria Teresa Zannetti
Keyword(s):  
Building Blocks ◽  
Chemoenzymatic Synthesis ◽  
New Family

scholarly journals Layer by Layer Antimicrobial Coatings Based on Nafion, Lysozyme, and Chitosan

Nanomaterials ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1563 ◽  
Author(s):  
Ella N. Gibbons ◽  
Charis Winder ◽  
Elliot Barron ◽  
Diogo Fernandes ◽  
Marta J. Krysmann ◽  
...  
Keyword(s):  
Surface Characteristics ◽  
Building Blocks ◽  
Layer By Layer ◽  
Exclusion Zone ◽  
Antimicrobial Coatings ◽  
Force Microscopy ◽  
New Family ◽  
Atomic Force ◽  
Multilayer Assemblies ◽  
And Staphylococcus Aureus

The study focuses on the development of a new family of layer-by-layer coatings comprising Nafion, lysozyme and chitosan to address challenges related to microbial contamination. Circular dichroism was employed to gain insights on the interactions of the building blocks at the molecular level. Quartz crystal microbalance tests were used to monitor in real time the build-up of multilayer coatings, while atomic force microscopy, contact angle and surface zeta potential measurements were performed to assess the surface characteristics of the multilayer assemblies. Remarkably, the nanocoated surfaces show almost 100% reduction in the population of both Escherichia coli and Staphylococcus aureus. The study suggests that Nafion based synergistic platforms can offer an effective line of defence against bacteria, facilitating antimicrobial mechanisms that go beyond the concept of exclusion zone.

Halogen-bonding in a new family of tris(haloanilato)metallate(iii) magnetic molecular building blocks

2014 ◽  
Vol 43 (19) ◽  
pp. 7006-7019 ◽  
Author(s):  
Matteo Atzori ◽  
Flavia Artizzu ◽  
Elisa Sessini ◽  
Luciano Marchiò ◽  
Danilo Loche ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Dft Calculations ◽  
Crystal Structures ◽  
General Formula ◽  
Halogen Bonding ◽  
Building Blocks ◽  
New Family ◽  
Molecular Building Blocks

Here we report on new tris(haloanilato)metallate(iii) complexes with general formula [M(X2An)3]3−, their crystal structures, DFT calculations and magnetic properties.

scholarly journals (S)-Pramipexole and Its Enantiomer, Dexpramipexole: A New Chemoenzymatic Synthesis and Crystallographic Investigation of Key Enantiomeric Intermediates

Catalysts ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 941
Author(s):  
Samuele Ciceri ◽  
Patrizia Ferraboschi ◽  
Paride Grisenti ◽  
Shahrzad Reza Elahi ◽  
Carlo Castellano ◽  
...  
Keyword(s):  
Single Crystal ◽  
Enantiomeric Excess ◽  
Three Dimensional ◽  
Building Blocks ◽  
Chemoenzymatic Synthesis ◽  
Racemic Mixture ◽  
Candida Antarctica Lipase ◽  
Crystallographic Investigation ◽  
Reaction Conditions ◽  
X Ray

A new chemoenzymatic method has been developed for the synthesis of (S)- and (R)-N-(6-hydroxy-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl) acetamide, two key synthons for the preparation of (S)-pramipexole, an anti-Parkinson drug, and its enantiomer dexpramipexole, which is currently under investigation for the treatment of eosinophil-associated disorders. These two building blocks have been obtained in good yields and high enantiomeric excess (30% and >98% ee for the R-enantiomer, and 31% and >99% ee for the S- one) through a careful optimization of the reaction conditions, starting from the corresponding racemic mixture and using two consecutive irreversible transesterifications, catalyzed by Candida antarctica lipase type A. Single crystal X-ray analysis has been carried out to unambiguously define the stereochemistry of the two enantiomers, and to explore in depth their three-dimensional features.

Design of a New Family of Inorganic Compounds Ae2F2SnX3(Ae = Sr, Ba; X = S, Se) Using Rock Salt and Fluorite 2D Building Blocks

2006 ◽  
Vol 45 (2) ◽  
pp. 917-922 ◽  
Author(s):  
Houria Kabbour ◽  
Laurent Cario ◽  
Michel Danot ◽  
Alain Meerschaut
Keyword(s):  
Rock Salt ◽  
Inorganic Compounds ◽  
Building Blocks ◽  
New Family

Isohexide hydroxy esters: synthesis and application of a new class of biobased AB-type building blocks

RSC Advances ◽  
2014 ◽  
Vol 4 (89) ◽  
pp. 47937-47950 ◽  
Author(s):  
Shanmugam Thiyagarajan ◽  
Jing Wu ◽  
Rutger J. I. Knoop ◽  
Jacco van Haveren ◽  
Martin Lutz ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Building Blocks ◽  
Ester Group ◽  
Hydroxyl Group ◽  
Secondary Hydroxyl ◽  
New Class ◽  
New Family ◽  
Hydroxy Esters

Here we present the synthesis of a new family of sugar derived 1,4:3,6-dianhydrohexitol based AB-type monomers, containing one methyl ester group and a secondary hydroxyl group in all four possible stereo isomers (RR, RS, SR, SS).

scholarly journals Naphthyl-Fused Phosphepines: Luminescent Contorted Polycyclic P-Heterocycles

2019 ◽  
Author(s):  
Thomas Delouche ◽  
Réka Mokrai ◽  
Thierry Roisnel ◽  
Denis Tondelier ◽  
Bernard Geffroy ◽  
...  
Keyword(s):  
Electronic Structure ◽  
Solid State ◽  
Phosphine Oxide ◽  
Steric Hindrance ◽  
Building Blocks ◽  
Redox Properties ◽  
Substitution Reactions ◽  
Pi Conjugated ◽  
New Family ◽  
Pi Systems

The article presents the synthesis of a new family of naphthyl-fused phosphepines through Ni-mediated C-C coupling. Interestingly, the chloro-phosphine-oxide intermediate shows strong resistance toward oxidation/hydrolysis due to a combination of steric hindrance and pnictogen interactions. However it can undergo substitution reactions under specific conditions. The optical / redox properties and the electronic structure of these new pi-systems were studied experimentally and computationally. Taking advantage of the luminescence of these derivatives, a blue emitting OLED has been prepared highlighting that these novel pi-conjugated P-heterocycles appear as promising building blocks for solid-state lightning applications.

scholarly journals Naphthyl-Fused Phosphepines: Luminescent Contorted Polycyclic P-Heterocycles

2019 ◽  
Author(s):  
Thomas Delouche ◽  
Réka Mokrai ◽  
Thierry Roisnel ◽  
Denis Tondelier ◽  
Bernard Geffroy ◽  
...  
Keyword(s):  
Electronic Structure ◽  
Solid State ◽  
Phosphine Oxide ◽  
Steric Hindrance ◽  
Building Blocks ◽  
Redox Properties ◽  
Substitution Reactions ◽  
Pi Conjugated ◽  
New Family ◽  
Pi Systems

The article presents the synthesis of a new family of naphthyl-fused phosphepines through Ni-mediated C-C coupling. Interestingly, the chloro-phosphine-oxide intermediate shows strong resistance toward oxidation/hydrolysis due to a combination of steric hindrance and pnictogen interactions. However it can undergo substitution reactions under specific conditions. The optical / redox properties and the electronic structure of these new pi-systems were studied experimentally and computationally. Taking advantage of the luminescence of these derivatives, a blue emitting OLED has been prepared highlighting that these novel pi-conjugated P-heterocycles appear as promising building blocks for solid-state lightning applications.

Introducing Molecular Diversity at the C20-position of Pregnenolone by the Formation of Spiro-2-morpholinones

2018 ◽  
Vol 15 (4) ◽  
pp. 541-551
Author(s):  
Guy Bertrand Djigoue ◽  
Donald Poirier
Keyword(s):  
Small Molecules ◽  
Molecular Diversity ◽  
Structural Diversity ◽  
Building Blocks ◽  
Dimensional Representation ◽  
Huge Amount ◽  
X Ray ◽  
3 Dimensional ◽  
New Family ◽  
New Compounds

Aim and Objective: The development of small molecules that can interact with key therapeutic target represents an active field of research. Therefore, new approaches for increasing the molecular diversity of a starting material, such as a natural product, are needed. Herein, the carbonyl group present on a pregnane scaffold, or easily obtained from the oxidation of the corresponding alcohol, was used to obtain a series of diversified steroidal morpholinone derivatives. Materials and Methods: Using chemical synthesis, two levels of molecular diversity were introduced at position 20 of a C21-steroid scaffold. Nuclear magnetic resonance (NMR) spectroscopy and x-ray analysis were next used to characterize the morpholinone derivatives. Results: The C-20 carbonyl of pregnenolone was first transformed into an oxirane that reacted with an amino acid and the resulting amino alcohol was then cyclized to generate different spiro-2-morpholinones. X-ray analysis of one representative compound confirmed the 3-dimensional representation of this new family of diversified steroid derivatives. NMR analysis supported the expected structure and identified key markers of the chiral center configuration found in the 2-morpholinone moiety. Finally, the NH of the morpholinone ring was alkylated, thus increasing structural diversity. Conclusion: Considering the huge amount of building blocks (amino acids, bromobenzyl derivatives and ketones) that are commercially available, the strategy reported herein opens the door to the synthesis of diversified libraries of new compounds.

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