Mucin Histochemical Analysis of the Ileocaecal Valve and Lymphoid Tissues of the Terminal Ileum: Role Against Tumour Invasion

We present a case of an unusually large, circumferential tubulovillous adenoma involving the terminal ileum and the caecum with ileocaecal valve consumption, presenting as intussusception in an otherwise healthy 90-year-old woman. The patient presented with several months of chronic symptoms of weight loss and diarrhoea. Clinical examination revealed a right-sided mass. Investigations revealed a large right-sided lesion suspicious of intussusception. The patient underwent a right-sided hemicolectomy where the intussusception was resected. Histology of the resected mass revealed a tubulovillous adenoma with focal invasive adenocarcinoma.

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Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement

Journal of Experimental Medicine ◽

10.1084/jem.20061884 ◽

2006 ◽

Vol 203 (13) ◽

pp. 2841-2852 ◽

Cited By ~ 487

Author(s):

Marcello Chieppa ◽

Maria Rescigno ◽

Alex Y.C. Huang ◽

Ronald N. Germain

Keyword(s):

Small Bowel ◽

Epithelial Cell ◽

Terminal Ileum ◽

Fluorescent Protein ◽

Dynamic Imaging ◽

Lymphoid Tissues ◽

Proximal Jejunum ◽

Chimeric Mouse ◽

Limited Information ◽

Tlr Signaling

Cells lining the gastrointestinal tract serve as both a barrier to and a pathway for infectious agent entry. Dendritic cells (DCs) present in the lamina propria under the columnar villus epithelium of the small bowel extend processes across this epithelium and capture bacteria, but previous studies provided limited information on the nature of the stimuli, receptors, and signaling events involved in promoting this phenomenon. Here, we use immunohistochemical as well as dynamic explant and intravital two-photon imaging to investigate this issue. Analysis of CD11c–enhanced green fluorescent protein (EGFP) or major histocompatibility complex CII-EGFP mice revealed that the number of trans-epithelial DC extensions, many with an unusual “balloon” shape, varies along the length of the small bowel. High numbers of such extensions were found in the proximal jejunum, but only a few were present in the terminal ileum. The extensions in the terminal ileum markedly increased upon the introduction of invasive or noninvasive Salmonella organisms, and chimeric mouse studies revealed the key role of MyD88-dependent Toll-like receptor (TLR) signaling by nonhematopoietic (epithelial) elements in the DC extension response. Collectively, these findings support a model in which epithelial cell TLR signaling upon exposure to microbial stimuli induces active DC sampling of the gut lumen at sites distant from organized lymphoid tissues.

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Metastases of lobular breast carcinoma in the terminal ileum and ileocaecal valve

Journal of Surgical Case Reports ◽

10.1093/jscr/rjv028 ◽

2015 ◽

Vol 2015 (3) ◽

pp. rjv028-rjv028 ◽

Cited By ~ 1

Author(s):

S. Abdalla ◽

P. Macneal ◽

C.-M. Borg

Keyword(s):

Breast Carcinoma ◽

Terminal Ileum ◽

Ileocaecal Valve ◽

Lobular Breast Carcinoma

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Some observations on the transport of food in the alimentary canal of the rat

Agricultural and Food Science ◽

10.23986/afsci.71350 ◽

1954 ◽

Vol 26 (1) ◽

pp. 2-9

Author(s):

Lauri Paloheimo ◽

Aarne Mäkelä ◽

Maija-Liisa Salo

Keyword(s):

Small Intestine ◽

Terminal Ileum ◽

Alimentary Canal ◽

Relative Rate ◽

Positive Influence ◽

The Other ◽

Ileocaecal Valve ◽

Series Of Experiments ◽

Classical Conception

Several series of experiments were arranged so as to study in the rat 1) the effect of the degree of the charge of the stomach upon its rate of emptying, and 2) the rate of passage of the food in the empty small intestine. It was observed that the fullness of the stomach had a positive influence on its rate of emptying. In the empty small intestine the transport of the food after the commencement of the meal is very rapid during the first 5 minutes. In this time the food is carried a distance from the pylorus comprising 53—65 % of the length of the small intestine. Five minutes later 65— 78 % of the small intestine contains experimental food. However, the terminal ileum does not appear to be less filled than the other parts of the small intestine. It contains a slimy liquid which has been forced from the »empty» small intestine towards the caecum. Evidently the ileocaecal valve has remained closed. Only after about 1 ½ hours does the food reach the distal end of the small intestine. It is obvious that the rapid filling of the duodenum and jejunum immediately after the beginning of the meal cannot be explained by the classical conception of peristalsis described by Bayliss and Starling. It is remarkable that in the rat the transport of food in the empty small intestine seems to occur at about the same relative rate as in man.

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PO110 METASTASES OF LOBULAR BREAST CARCINOMA IN THE TERMINAL ILEUM AND ILEOCAECAL VALVE

The Breast ◽

10.1016/s0960-9776(15)30122-3 ◽

2015 ◽

Vol 24 ◽

pp. S59

Author(s):

Sala Abdalla ◽

Peter Macneal ◽

Cynthia-Michelle Borg

Keyword(s):

Breast Carcinoma ◽

Terminal Ileum ◽

Ileocaecal Valve ◽

Lobular Breast Carcinoma

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Lipomatosis of the terminal ileum and ileocaecal valve: multidetector CT findings

BMJ Case Reports ◽

10.1136/bcr-2013-201399 ◽

2013 ◽

Vol 2013 (nov15 1) ◽

pp. bcr2013201399-bcr2013201399

Author(s):

I. S. Parlak ◽

A. E. Okay ◽

H. Kaplanoglu ◽

G. Kuscuoglu

Keyword(s):

Terminal Ileum ◽

Multidetector Ct ◽

Ileocaecal Valve ◽

Ct Findings

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Fine Structural Alterations in Thyroid Follicular Cells (FC) and Changes in Serum Thyroxine Produced by Feeding Polychlorinated Biphenyl (PCB) to Rats

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100079929 ◽

1977 ◽

Vol 35 ◽

pp. 498-499

Author(s):

W.T. Collins ◽

Charles C. Capen ◽

Louis Kasza

Keyword(s):

Feed Efficiency ◽

Polychlorinated Biphenyl ◽

Serum Proteins ◽

Skin Lesions ◽

Hepatic Necrosis ◽

Ultrastructural Changes ◽

Lymphoid Tissues ◽

Heat Transfer Fluids ◽

Thyroid Follicular Cells ◽

Peripheral Metabolism

The widespread contamination of the environment with PCB, a compound used extensively by industry in hydraulic and heat transfer fluids as well as plasticizers and solvents in adhesives and sealants, has resulted in detectable tissue levels in a large portion of the human population, domestic animals, and wildlife. Intoxication with PCB produces severe hepatic necrosis, degeneration of lymphoid tissues and kidney, skin lesions, decreased reproductive performance, reduced feed efficiency, and decreased weight gain. PCB also has been reported to reduce the binding of thyroid hormone to serum proteins and enhance the peripheral metabolism of thyroxine with increased excretion of thyroxine-glucuronide in the bile (Bastomsky, Endocrinology 95: 1150-1155, 1974).The objectives of this investigation were (1) to investigate the histopathologic, histochemical, and ultrastructural changes in thyroid FC produced by the acute (4 week) and chronic (12 week) administration of low (50 ppm) and high (500 ppm) doses of PCB to rats, (2) to correlate these alterations to changes in serum immunoreactive thyroxine concentration, and (3) to investigate the persistence of the effects of PCB on the thyroid gland.

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