Joint space width of the tibiofemoral and of the patellofemoral joint in chronic knee pain with or without radiographic osteoarthritis: a 2-year follow-up

Purpose: the aim of the study was to compare the minimal joint-space (MJS) width of the tibiofemoral joint (TFJ) in weight-bearing radiograms with the patient in two different positions Material and Methods: from a study of 54 patients with chronic knee pain (aged 42–59 years, mean 52 years), we selected 21 consecutive patients for this study. in these 21 patients, both knees were examined by means of p.a. weight-bearing radiograms in semiflexion with fluoroscopic guidance. the patient stood with the weight: 1) almost entirely on the examined leg; and 2) equally distributed on both legs. the MJS was measured with a scale loupe in tenths of a millimeter in the medial and lateral compartments of the TFJ Results: with the patient standing on one leg, the MJS was 0.18 mm wider (p<0.006) in the medial compartment and 0.18 mm narrower (p<0.029) in the lateral compartment as compared to standing on both legs Conclusion: with the technique used, the assessment of the MJS width in the p.a. view of the TFJ in weight-bearing examinations should be performed with equal weight on both legs. Standing on only the examined leg might be an option in cases of suspected narrowing in the lateral compartment

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Clinical Risk Factors Associated with Radiographic Osteoarthritis Progression Among People with Knee Pain: A Longitudinal Study

10.21203/rs.3.rs-67862/v1 ◽

2020 ◽

Author(s):

Milena Simic ◽

Alison R. Harmer ◽

Maria Agaliotis ◽

Lillias Nairn ◽

Lisa Bridgett ◽

...

Keyword(s):

Physical Activity ◽

Joint Space Width ◽

Joint Space ◽

Clinical Factors ◽

Physical Activity Guidelines ◽

Factors Associated ◽

Radiographic Osteoarthritis ◽

Osteoarthritis Progression ◽

Space Width

Abstract Background:The aim of this study was to identify modifiable clinical factors associated with radiographic osteoarthritis progression over one-to-two years in people with painful medial knee osteoarthritis.Methods:A longitudinal study was conducted within a randomised controlled trial, the “Long-term Evaluation of Glucosamine Sulfate” (LEGS study). Recruitment occurred 2007-2009, with one and two-year follow-up assessments by blinded assessors. Community-dwelling people with chronic knee pain (≥4/10) and medial tibiofemoral narrowing (but retaining >2mm medial joint space width) on radiographs were recruited. From 605 participants, follow-up data were available for 498 (82%, mean[sd] age: 60[8] years). Risk factors evaluated at baseline were pain, physical function, use of non-steroidal anti-inflammatory drugs (NSAIDs), statin use, not meeting physical activity guidelines, presence of Heberden’s nodes, history of knee surgery/trauma, and manual occupation. Multivariable logistic regression analysis was conducted adjusting for age, sex, obesity, high blood pressure, allocation to glucosamine and chondroitin treatment, and baseline structural disease severity (Kellgren and Lawrence grade, joint space width and varus alignment). Radiographic osteoarthritis progression was defined as joint space narrowing ≥0.5mm over one-to-two years (latest follow-up used where available).Results:Radiographic osteoarthritis progression occurred in 58 participants (12%). Clinical factors independently associated with radiographic progression were: use of NSAIDs, adjusted odds ratios (OR) and 95% confidence intervals (CI) 2.05 (95%CI:1.1 to 3.8), and not meeting physical activity guidelines, OR 2.07 (95%CI:0.9 to 4.7).Conclusions: Among people with mild radiographic knee osteoarthritis, people who use NSAIDs and/or do not meet physical activity guidelines have greater risk of radiographic osteoarthritis progression.Trial Registration: This original study trial was registered apriori. ClinicalTrials.gov identifier: NCT00513422; http://www.clinicaltrials.gov. Current study hypothesis arose before inspection of the data.

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Clinical risk factors associated with radiographic osteoarthritis progression among people with knee pain: a longitudinal study

Arthritis Research & Therapy ◽

10.1186/s13075-021-02540-9 ◽

2021 ◽

Vol 23 (1) ◽

Author(s):

Milena Simic ◽

Alison R. Harmer ◽

Maria Agaliotis ◽

Lillias Nairn ◽

Lisa Bridgett ◽

...

Keyword(s):

Physical Activity ◽

Joint Space Width ◽

Joint Space ◽

Clinical Factors ◽

Physical Activity Guidelines ◽

Factors Associated ◽

Radiographic Osteoarthritis ◽

Osteoarthritis Progression ◽

Space Width

Abstract Background The aim of this study was to identify modifiable clinical factors associated with radiographic osteoarthritis progression over 1 to 2 years in people with painful medial knee osteoarthritis. Methods A longitudinal study was conducted within a randomised controlled trial, the “Long-term Evaluation of Glucosamine Sulfate” (LEGS study). Recruitment occurred in 2007–2009, with 1- and 2-year follow-up assessments by blinded assessors. Community-dwelling people with chronic knee pain (≥4/10) and medial tibiofemoral narrowing (but retaining >2mm medial joint space width) on radiographs were recruited. From 605 participants, follow-up data were available for 498 (82%, mean [sd] age 60 [8] years). Risk factors evaluated at baseline were pain, physical function, use of non-steroidal anti-inflammatory drugs (NSAIDs), statin use, not meeting physical activity guidelines, presence of Heberden’s nodes, history of knee surgery/trauma, and manual occupation. Multivariable logistic regression analysis was conducted adjusting for age, sex, obesity, high blood pressure, allocation to glucosamine and chondroitin treatment, and baseline structural disease severity (Kellgren and Lawrence grade, joint space width, and varus alignment). Radiographic osteoarthritis progression was defined as joint space narrowing ≥0.5mm over 1 to 2 years (latest follow-up used where available). Results Radiographic osteoarthritis progression occurred in 58 participants (12%). Clinical factors independently associated with radiographic progression were the use of NSAIDs, adjusted odds ratios (OR) and 95% confidence intervals (CI) 2.05 (95% CI 1.1 to 3.8), and not meeting physical activity guidelines, OR 2.07 (95% CI 0.9 to 4.7). Conclusions Among people with mild radiographic knee osteoarthritis, people who use NSAIDs and/or do not meet physical activity guidelines have a greater risk of radiographic osteoarthritis progression. Trial registration ClinicalTrials.gov, NCT00513422. This original study trial was registered a priori, on August 8, 2007. The current study hypothesis arose before inspection of the data.

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Minimum joint space width (mJSW) of patellofemoral joint on standing “skyline” radiographs: test-retest reproducibility and comparison with quantitative magnetic resonance imaging (qMRI)

Skeletal Radiology ◽

10.1007/s00256-013-1701-9 ◽

2013 ◽

Vol 42 (11) ◽

pp. 1573-1582 ◽

Cited By ~ 1

Author(s):

Paolo Simoni ◽

Sanaa Jamali ◽

Adelin Albert ◽

Saara Totterman ◽

Edward Schreyer ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Patellofemoral Joint ◽

Joint Space Width ◽

Joint Space ◽

Resonance Imaging ◽

Quantitative Magnetic Resonance Imaging ◽

Quantitative Magnetic Resonance ◽

Minimum Joint Space Width ◽

Space Width

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Association between disease progression and depression onset in persons with radiographic knee osteoarthritis

Rheumatology ◽

10.1093/rheumatology/keaa141 ◽

2020 ◽

Vol 59 (11) ◽

pp. 3390-3399

Author(s):

Alan M Rathbun ◽

Michelle D Shardell ◽

Alice S Ryan ◽

Michelle S Yau ◽

Joseph J Gallo ◽

...

Keyword(s):

Disease Progression ◽

Disease Severity ◽

Gait Speed ◽

Joint Space Width ◽

Joint Space ◽

Knee Oa ◽

Increased Risk ◽

Pain Subscale ◽

Space Width

Abstract Objectives Osteoarthritis (OA) disease progression may lead to deteriorating psychosocial function, but it is unclear what aspects of disease severity are related to the onset of depression. This study assessed which components of OA disease progression cumulatively contribute to depression onset in persons with radiographic knee OA. Methods Osteoarthritis Initiative participants (n = 1651) with radiographic disease (Kellgren-Lawrence grade ≥2) in one or both knees and below the screening threshold for probable depression [Center for Epidemiological Studies Depression (CES-D) scale <16] at baseline were included. Disease severity was measured from baseline to the third annual follow-up visit using joint space width, 20-meter gait speed, and the Western Ontario and McMaster Universities Osteoarthritis Index pain subscale, each categorized into quintiles. Depression onset (CES-D ≥ 16) was assessed annually at four follow-up visits. Marginal structural models that account for time-dependent confounding and attrition evaluated the association between each time-varying disease severity measure and depression onset. Results Each disease severity measure exhibited a non-linear relationship concerning the probability of depression onset, with the higher quintiles generally being associated with a larger risk. The highest quintile (relative to the lowest) of joint space width and gait speed were both significantly associated with depression onset. By contrast, none of the higher pain quintiles compared with the lowest were significantly associated with the onset of depression. Conclusion Faster disease progression as measured by either worsening structural severity or decreasing physical performance corresponds to an increased risk of depression among individuals with radiographic knee OA.

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Changes in Knee Joint Space Width in Treatment with a New Hyaluronic-Based Hydrogel

Acta Medica Marisiensis ◽

10.1515/amma-2017-0017 ◽

2017 ◽

Vol 63 (3) ◽

pp. 125-128

Author(s):

Octav Marius Russu ◽

Andrei Marian Feier ◽

Tudor Sorin Pop ◽

Marcela Todoran ◽

István Gergely

Keyword(s):

Hyaluronic Acid ◽

Knee Joint ◽

Knee Osteoarthritis ◽

Joint Space Narrowing ◽

Joint Space Width ◽

Joint Space ◽

One Year ◽

A Minor ◽

Space Width

AbstractObjective: Our purpose was to assess the effect of a new hyaluronic acid-based (Hymovis®) injections on joint space width narrowing in patients diagnosed with knee osteoarthritis.Methods: A prospective clinical trial was conducted in the Department of Orthopedics and Traumatology II from the Clinical County Hospital, Tîrgu Mureș, Romania. Thirty-five patients diagnosed with idiopathic knee osteoarthritis received two intraarticular injections with hyaluronic acid-based hydrogel (24 mg of hyaluronic acid/3 ml) at one-week interval. Anteroposterior radiographs were obtained before the injections, at six and twelve months after. Minimum joint space width was measured by two senior orthopaedics surgeons at each follow up. Each radiograph was measured again by the same evaluators two weeks apart.Results: Thirty-one patients were present at the final follow-up. A minor reduction in mean weight was noticed (from 82.2 kg ± 16.2 kg to 80.9 kg ± 16.0, p > 0.398) without any correlation with joint space width narrowing. There were no major changes at the first follow up (6 months) regarding joint space narrowing. A reduction in joint space width was observed however at 12 months varying from 4.4 mm (SD ± 1.64, range 1.8-7.1) at the first assessment to 4.3 mm (SD ± 1.26, range 0.0-6.8) at the final follow-up but with no statistical difference (p=0.237).Conclusion: No significant modification in joint space width at the final follow-up secondarily proved that two injections of Hymovis® may slow down narrowing in the knee joint space over a one-year period.

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Sensitivity-to-change and validity of semi-automatic joint space width measurements in hand osteoarthritis: a follow-up study

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2016.02.002 ◽

2016 ◽

Vol 24 (7) ◽

pp. 1172-1179 ◽

Cited By ~ 6

Author(s):

W. Damman ◽

M.C. Kortekaas ◽

B.C. Stoel ◽

R. van 't Klooster ◽

R. Wolterbeek ◽

...

Keyword(s):

Joint Space Width ◽

Joint Space ◽

Hand Osteoarthritis ◽

Sensitivity To Change ◽

Follow Up Study ◽

Width Measurements ◽

Space Width

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SAT0431 Threshold of Joint Space Width for Knee Pain: The Road Study

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2016-eular.2302 ◽

2016 ◽

Vol 75 (Suppl 2) ◽

pp. 827.2-827

Author(s):

S. Muraki ◽

T. Akune ◽

H. Oka ◽

S. Tanaka ◽

H. Kawaguchi ◽

...

Keyword(s):

Knee Pain ◽

Joint Space Width ◽

Joint Space ◽

The Road ◽

Road Study ◽

Space Width

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Joint-space width in the axial view of the patello-femoral joint

Acta Radiologica ◽

10.1080/02841859809172144 ◽

1998 ◽

Vol 39 (1) ◽

pp. 24-31 ◽

Cited By ~ 4

Author(s):

T. Boegård ◽

O. Rudling ◽

I. F. Petersson ◽

J. Sanfridsson ◽

T. Saxne ◽

...

Keyword(s):

Knee Pain ◽

Joint Space Width ◽

Joint Space ◽

Cartilage Defects ◽

Proton Density ◽

Bony Landmark ◽

Mr Images ◽

Chronic Knee Pain ◽

Articular Surfaces ◽

Axial View

Purpose: to validate a bony landmark on the dorsal aspect of the patella for measurement of the interbone distance in the axial radiogram of the patello-femoral joint (PFJ); to assess the reproducibility of this radiogram and the minimal joint-space (MJS) width measurements in the medial and lateral compartments of the PFJ in this view; and to relate the MJS of the PFJ to MR-detected cartilage defects in the same joint Material and Methods: Fifty-seven individuals with chronic knee pain (aged 41–58 years, mean 50 years) were examined with an axial view of the PFJ in the standing position. the MJS was measured with a mm-graded ruler. on the same day, an MR examination was performed with proton density- and T2-weighted turbo spin-echo sequences on a 1.0 T imager. We noted the cartilage defects in the PFJ in axial and sagittal MR images, and the shape of the sub-chondral cortex of the medial and lateral articular surfaces of the patella in sagittal MR images Results and Conclusion: the bony landmark was found on all articular surfaces. the axial view of the PFJ and the MJS measurements were reproducible. an MJS of < 5 mm showed high specificity for MR-detected cartilage defects. Thus an MJS of 5 mm proved to be a limit in the diagnosis of joint-space narrowing in the PFJ in middle-aged individuals with chronic knee pain

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