409 DIFFERENCES IN BASELINE PAIN TOLERANCE IN AN EXPERIMENTAL PAIN MODEL IN ELDERLY (≥75) VERSUS YOUNG (18–40) SUBJECTS

2009 ◽  
Vol 13 (S1) ◽  
Author(s):  
S. Skinner‐Robertson ◽  
C.L. Chen ◽  
F. Varin
Keyword(s):  
Experimental Pain ◽  
Pain Tolerance ◽  
Pain Model

scholarly journals Evaluation of an Experimental Pain Model by Noncompartmental Analysis of Results from a Randomized Placebo Controlled Trial

2018 ◽  
Vol 1 (21;1) ◽  
pp. 363-372
Author(s):  
France Varin
Keyword(s):  
Active Treatment ◽  
Controlled Trial ◽  
Experimental Pain ◽  
The Elderly ◽  
Pain Tolerance ◽  
Age Group ◽  
Noncompartmental Analysis ◽  
Time Curve ◽  
Pain Model ◽  
Significant Difference

Background: Understanding analgesic pharmacodynamics (PD) in the elderly is key to optimising pain management. Electrically stimulated pain models (ESPM) permit assessment of pain responses in humans. C and Aδ sensory fibres convey pain and respond to low frequency electrical stimulus (5 and 250 Hz, respectively). Human research suggests pain tolerance threshold (PTT) is similar or decreases with age. Objectives: To determine whether an ESPM is able to detect a difference in PTT in elderly (≥ 75 years) and young (20-40 years) subjects after single dose administration of a placebo and tramadol, a low potency analgesic. Study Design: Two-cohort, randomized, placebo-controlled, cross-over study. Methods: A noncompartmental analysis of data at 17 timepoints on 5 Hz and 250 Hz PTT over 24 h. Results: Young (16) and elderly (13) patients showed similar baseline (E0) PTT between active and placebo both overall and by age group in both frequencies. Net drug effect took into account negative and positive changes from E0. In the elderly, net peak effect on PTT produced by active treatment was significantly greater for both 5 Hz (34%) and 250 Hz (30%). Net area under the 24-h effect-time curve during active treatment was significantly higher for both 5 Hz (163 %) and 250 Hz (175%) stimulations in the elderly. No clinically significant difference was observed in the young. Limitations: High variability in young subjects, despite efforts to remove outliers limited our ability to draw conclusions in that age group. Generalizability of results obtained from an experimental pain model in volunteers to treatment of elderly patients may be limited. Conclusion: ESPM can detect a difference for pain tolerance threshold between placebo and tramadol administration in the elderly. Although both 5 Hz and 250 Hz stimulations can detect a difference, the effect size for 5 Hz is larger and seems more precise and reliable, particularly in the elderly. Key words: Electrical pain model, elderly, geriatric, tramadol, placebo, opioid, area under the effect curve, noncompartmental analysis

scholarly journals Preferred musical attribute dimensions underlie individual differences in music-induced analgesia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Krzysztof Basiński ◽  
Agata Zdun-Ryżewska ◽  
David M. Greenberg ◽  
Mikołaj Majkowicz
Keyword(s):  
Individual Differences ◽  
Pain Perception ◽  
Specific Effect ◽  
Experimental Pain ◽  
Pain Tolerance ◽  
Order Effects ◽  
Individual Preferences ◽  
Pain Stimulation ◽  
Musical Excerpts ◽  
Average Pain

AbstractMusic-induced analgesia (MIA) is a phenomenon that describes a situation in which listening to music influences pain perception. The heterogeneity of music used in MIA studies leads to a problem of a specific effect for an unspecified stimulus. To address this, we use a previously established model of musical preferences that categorizes the multidimensional sonic space of music into three basic dimensions: arousal, valence and depth. Participants entered an experimental pain stimulation while listening to compilations of short musical excerpts characteristic of each of the three attribute dimensions. The results showed an effect on the part of music attribute preferences on average pain, maximal pain, and pain tolerance after controlling for musical attributes and order effects. This suggests that individual preferences for music attributes play a significant role in MIA and that, in clinical contexts, music should not be chosen arbitrarily but according to individual preferences.

The association between selected genetic variants and individual differences in experimental pain

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Marie Udnesseter Lie ◽  
Bendik Winsvold ◽  
Johannes Gjerstad ◽  
Dagfinn Matre ◽  
Linda M. Pedersen ◽  
...  
Keyword(s):  
Individual Differences ◽  
Genetic Variants ◽  
Pain Threshold ◽  
Experimental Pain ◽  
Pain Tolerance ◽  
Heat Pain ◽  
Low Back ◽  
Secondary Hyperalgesia ◽  
Heat Pain Threshold ◽  
Pain Patients

AbstractObjectivesThe underlying mechanisms for individual differences in experimental pain are not fully understood, but genetic susceptibility is hypothesized to explain some of these differences. In the present study we focus on three genetic variants important for modulating experimental pain related to serotonin (SLC6A4 5-HTTLPR/rs25531 A>G), catecholamine (COMT rs4680 Val158Met) and opioid (OPRM1 rs1799971 A118G) signaling. We aimed to investigate associations between each of the selected genetic variants and individual differences in experimental pain.MethodsIn total 356 subjects (232 low back pain patients and 124 healthy volunteers) were genotyped and assessed with tests of heat pain threshold, pressure pain thresholds, heat pain tolerance, conditioned pain modulation (CPM), offset analgesia, temporal summation and secondary hyperalgesia. Low back pain patients and healthy volunteers did not differ in regards to experimental test results or allelic frequencies, and were therefore analyzed as one group. The associations were tested using analysis of variance and the Kruskal-Wallis test.ResultsNo significant associations were observed between the genetic variants (SLC6A4 5-HTTLPR/rs25531 A>G, COMT rs4680 Val158Met and OPRM1 rs1799971 A118G) and individual differences in experimental pain (heat pain threshold, pressure pain threshold, heat pain tolerance, CPM, offset analgesia, temporal summation and secondary hyperalgesia).ConclusionsThe selected pain-associated genetic variants were not associated with individual differences in experimental pain. Genetic variants well known for playing central roles in pain perception failed to explain individual differences in experimental pain in 356 subjects. The finding is an important contribution to the literature, which often consists of studies with lower sample size and one or few experimental pain assessments.

Attenuation of Experimental Pain by Tactile Stimulation: Effect of Vibration at Different Levels of Noxious Stimulus Intensity

1964 ◽  
Vol 19 (1) ◽  
pp. 311-316 ◽  
Author(s):  
Bernard Blitz ◽  
Albert J. Dinnerstein ◽  
Milton Lowenthal
Keyword(s):  
Stimulus Intensity ◽  
Tactile Stimulation ◽  
Experimental Pain ◽  
Pain Tolerance ◽  
Noxious Stimulus ◽  
Noxious Stimulation ◽  
Vibratory Stimulus ◽  
Vibratory Stimulation ◽  
Electric Shocks ◽  
Different Levels

The present study was concerned with the masking and pain-attenuating effect of vibration at different levels of intensity of noxious stimulation. Forty Ss were given noxious stimulation in the form of increasingly painful electric shocks in trials where such shocks were presented with and without concurrent vibratory stimulation. The masking or pain-attenuating effect of the vibration was greatest at the lowest level of noxious stimulus intensity and decreased as the noxious stimulation intensity increased. At the highest level of noxious stimulation the effect of vibration was not significant although there was a tendency for Ss with higher pain tolerance to show summation. The possible relevance of the intensity of the vibratory stimulus to this pattern of results was discussed.

scholarly journals Laboratory Personnel Gender and Cold Pressor Apparatus Affect Subjective Pain Reports

2014 ◽  
Vol 19 (1) ◽  
pp. e13-e18 ◽  
Author(s):  
Jacob M Vigil ◽  
Lauren N Rowell ◽  
Joe Alcock ◽  
Randy Maestes
Keyword(s):  
Pain Sensitivity ◽  
Experimental Pain ◽  
Cold Pressor ◽  
Pain Tolerance ◽  
Cold Pain ◽  
Laboratory Personnel ◽  
Subjective Pain ◽  
Lower Pain ◽  
Pain Reporting ◽  
Pain Reports

BACKGROUND: There is no standardized method for cold pressor pain tasks across experiments. Temperature, apparatus and aspects of experimenters vary widely among studies. It is well known that experimental pain tolerance is influenced by setting as well as the sex of the experimenter. It is not known whether other contextual factors influence experimental pain reporting.OBJECTIVES: The present two-part experiment examines whether minimizing and standardizing interactions with laboratory personnel (eg, limiting interaction with participants to consenting and questions and not during the actual pain task) eliminates the influence of examiner characteristics on subjective pain reports and whether using different cold pain apparatus (cooler versus machine) influences reports.METHODS:The present experiment manipulated the gender of the experimenter (male, female and transgender) and the type of cold pressor task (CPT) apparatus (ice cooler versus refrigerated bath circulator). Participants conducted the CPT at one of two pain levels (5°C or 16°C) without an experimenter present.RESULTS:Men and women showed lower pain sensitivity when they were processed by biological male personnel than by biological female personnel before the CPT. Women who interacted with a transgendered researcher likewise reported higher pain sensitivity than women processed by biological male or female researchers. The type of CPT apparatus, despite operating at equivalent temperatures, also influenced subjective pain reports.DISCUSSION: The findings show that even minimal interactions with laboratory personnel who differ in gender, and differences in laboratory materials impact the reliable measurement of pain.CONCLUSION: More standardized protocols for measuring pain across varying research and clinical settings should be developed.

scholarly journals Experimental pain tolerance is decreased and independent of clinical pain intensity in patients with endometriosis

2018 ◽  
Vol 110 (6) ◽  
pp. 1118-1128 ◽  
Author(s):  
Mieke van Aken ◽  
Joukje Oosterman ◽  
Tineke van Rijn ◽  
Kelly Woudsma ◽  
Magdalena Ferdek ◽  
...  
Keyword(s):  
Pain Intensity ◽  
Experimental Pain ◽  
Pain Tolerance ◽  
Clinical Pain

scholarly journals Gender Differences in Response to Experimental Pain among Medical Students from a Western State of India

2014 ◽  
Vol 2 (1) ◽  
pp. 13-17
Author(s):  
Pratik Akhani ◽  
Samir Mendpara ◽  
Bhupendra Palan
Keyword(s):  
Blood Pressure ◽  
Gender Differences ◽  
Medical Students ◽  
Pain Sensitivity ◽  
Pain Threshold ◽  
Experimental Pain ◽  
Pain Tolerance ◽  
Medical Attention ◽  
Pain Rating ◽  
Western State

Background: Pain is one of the most common reasons for patients to seek medical attention and it causes considerable human suffering. Pain is a complex perception that differs enormously among individual patients. Gender plays an important role in how pain is experienced, coped with and treated. Even young healthy individuals often differ in how they perceive and cope with pain. This study was done to investigate gender differences in response to experimental pain among medical students from a western state in India. Methods: A total of 150 medical students (86 males and 64 females) participated in this interventional study. The Cold Pressor Test was used to exert experimental pain. To study the response, cardiovascular measures (radial pulse, systolic blood pressure and diastolic blood pressure) and pain sensitivity parameters (pain threshold, pain tolerance and pain rating) were assessed. Results: No significant difference was found in cardiovascular response to experimental pain between both the genders (p>0.05). Pain threshold and pain tolerance were found to be significantly higher in males whereas pain rating was found to be significantly higher in females (p<0.01). Pulse reactivity showed a negative relationship with pain threshold and pain tolerance whereas a positive relationship with pain rating, however no statistically significant relation was found between these measures. Conclusion: Females display greater pain sensitivity than males. Different pain perception might account for gender difference in pulse reactivity.

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