Recombinant Mycobacterium bovis BCG producing the circumsporozoite protein of Plasmodium falciparum FCC-1/HN strain induces strong immune responses in BALB/c mice

2002 ◽  
Vol 51 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Chunfu Zheng ◽  
Peimei Xie ◽  
Yatang Chen
Keyword(s):  
Plasmodium Falciparum ◽  
Immune Responses ◽  
Mycobacterium Bovis ◽  
Circumsporozoite Protein ◽  
Mycobacterium Bovis Bcg

scholarly journals How to induce protective humoral immunity against Plasmodium falciparum circumsporozoite protein

2022 ◽  
Vol 219 (2) ◽  
Author(s):  
Ilka Wahl ◽  
Hedda Wardemann
Keyword(s):  
Plasmodium Falciparum ◽  
Immune Responses ◽  
Vaccine Efficacy ◽  
Circumsporozoite Protein ◽  
Surface Proteins ◽  
Humoral Immune ◽  
Cell Responses ◽  
Humoral Immune Responses ◽  
Parasite Plasmodium ◽  
Parasite Plasmodium Falciparum

The induction of protective humoral immune responses against sporozoite surface proteins of the human parasite Plasmodium falciparum (Pf) is a prime goal in the development of a preerythrocytic malaria vaccine. The most promising antibody target is circumsporozoite protein (CSP). Although PfCSP induces strong humoral immune responses upon vaccination, vaccine efficacy is overall limited and not durable. Here, we review recent efforts to gain a better molecular and cellular understanding of anti-PfCSP B cell responses in humans and discuss ways to overcome limitations in the induction of stable titers of high-affinity antibodies that might help to increase vaccine efficacy and promote long-lived protection.

Clinical evaluation of serodiagnosis of active tuberculosis by multiple-antigen ELISA using lipids from Mycobacterium bovis BCG Tokyo 172

2005 ◽  
Vol 43 (11) ◽  
Author(s):  
Yukiko Fujita ◽  
Hideo Ogata ◽  
Ikuya Yano
Keyword(s):  
Immune Responses ◽  
Mycobacterium Bovis ◽  
Clinical Evaluation ◽  
Active Tuberculosis ◽  
Mycobacterium Bovis Bcg ◽  
Lipid Antigens ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Antigen Elisa ◽  
Multiple Antigen

AbstractThe humoral immune responses of 69 active tuberculosis (TB) patients against three major mycobacterial lipid antigens, monoacyl phosphatidylinositol dimannoside (Ac-PIM

Comparison of antibody and cell-mediated immune responses of foals and adult horses after vaccination with live Mycobacterium bovis BCG

Vaccine ◽  
2014 ◽  
Vol 32 (12) ◽  
pp. 1362-1367 ◽  
Author(s):  
Tracy L. Sturgill ◽  
Steeve Giguère ◽  
Londa J. Berghaus ◽  
David J. Hurley ◽  
Mary K. Hondalus
Keyword(s):  
Immune Responses ◽  
Mycobacterium Bovis ◽  
Mycobacterium Bovis Bcg

scholarly journals IMMUNE RESPONSES OF WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) TO MYCOBACTERIUM BOVIS BCG VACCINATION

2004 ◽  
Vol 40 (1) ◽  
pp. 66-78 ◽  
Author(s):  
W. R. Waters ◽  
M. V. Palmer ◽  
D. L. Whipple ◽  
R. E. Slaughter ◽  
S. L. Jones
Keyword(s):  
Immune Responses ◽  
Odocoileus Virginianus ◽  
Mycobacterium Bovis ◽  
Mycobacterium Bovis Bcg ◽  
Bcg Vaccination

scholarly journals Mechanisms of protective immune responses induced by the Plasmodium falciparum circumsporozoite protein-based, self-assembling protein nanoparticle vaccine

2013 ◽  
Vol 12 (1) ◽  
pp. 136 ◽  
Author(s):  
Margaret E McCoy ◽  
Hannah E Golden ◽  
Tais APF Doll ◽  
Yongkun Yang ◽  
Stephen A Kaba ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Immune Responses ◽  
Circumsporozoite Protein ◽  
Self Assembling

scholarly journals Immune Responses Induced in Cattle by Vaccination with a Recombinant Adenovirus Expressing Mycobacterial Antigen 85A and Mycobacterium bovis BCG

2006 ◽  
Vol 74 (2) ◽  
pp. 1416-1418 ◽  
Author(s):  
H. Martin Vordermeier ◽  
Kris Huygen ◽  
Mahavir Singh ◽  
R. Glyn Hewinson ◽  
Zhou Xing
Keyword(s):  
Immune Responses ◽  
Mycobacterium Bovis ◽  
Recombinant Adenovirus ◽  
Gamma Interferon ◽  
Mycobacterial Antigen ◽  
Mycobacterium Bovis Bcg ◽  
Bcg Vaccination ◽  
Interferon Responses

ABSTRACT Cattle were vaccinated with an adenovirus expressing the mycobacterial antigen 85A (rAd85A), with Mycobacterium bovis BCG followed by rAd85A heterologous boosting, or with rAd85A followed by BCG boosting. BCG/rAd85A resulted in the highest direct gamma interferon responses. Cultured enzyme-linked immunospot assay analysis demonstrated that memory responses were induced by all three protocols but were strongest after BCG/rAd85A and rAd85A/BCG vaccination.

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