Systematic studies of the lead and yttrium substituted Bi-2212 phase were performed on various compositions ranging between 0 and 0.8 for Pb and between 0 and 0.9 for Y. Crystallographic measurements reveal that the two modulations observed in unleaded and highly Pb-substituted samples are closely linked, the main differences being that the commensurate component disappears in type II (lead type) modulation, along with the modulation of the Bi 3+ ion. We argue that this is due to a covalent bonding between Bi-O planes. The study of internal parameters, including modulation amplitudes, of the Bi2Sr2 ( Ca 1-x, Y x) Cu2O 8+x/2+δ system reveals three distinct regimes with very different behaviors, corresponding to the overdoped, underdoped and insulating regimes. By comparing these results to the variation of the diamagnetic shielding with Y and Pb contents, we conclude that yttrium and lead affect more the mobility of the holes than the hole concentration itself. Y seems to induce, rather than a metal/insulator transition, a switch from a three-dimensional to a two-dimensional regime with a hole localization in the CuO 2 planes.