L0026 Risk of headaches and sleep disturbances following mild traumatic brain injury: a preliminary report

2007 ◽  
Vol 8 ◽  
pp. S104
Author(s):  
G. Chaput ◽  
C. Manzini ◽  
R. Denis ◽  
A. Demers ◽  
J.-F. Giguère ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Preliminary Report ◽  
Sleep Disturbances

scholarly journals Comparison of Neurocognitive Testing and the Measurement of Marinobufagenin in Mild Traumatic Brain Injury: A Preliminary Report

2015 ◽  
Vol 9 ◽  
pp. JEN.S27921 ◽  
Author(s):  
Joel Oliver ◽  
Kamran Abbas ◽  
J. Timothy Lightfoot ◽  
Kelly Baskin ◽  
Blaise Collins ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Preliminary Report ◽  
Athletic Trainers ◽  
Brain Trauma ◽  
Return To Play ◽  
Neurocognitive Testing ◽  
Testing Procedures ◽  
Full Activity

The evaluation of concussed athletes, including testing to determine if and when they may return to play, has become an important task of athletic trainers and team physicians. Currently, concussion protocols are in place, which depend largely upon assessments based upon neurocognitive testing (NCT). The authors have evaluated the use of a biomarker of brain trauma, marinobufagenin (MBG), and compared its application in concussed athletes with the performance of NTC. We found a disparity between these two testing procedures. In this communication, the findings of these comparative data are presented. We noted that athletes whose NCT evaluations had returned to baseline and who were allowed to again participate in play then showed a recurrence of elevated urinary MBG excretion. These observations raise concern as to the processes currently in effect with regard to the decision as to returning athletes to the full activity. They suggest a need for further evaluation.

scholarly journals The functional roles of IGF-1 variants in the susceptibility and clinical outcomes of mild traumatic brain injury

2019 ◽  
Vol 26 (1) ◽  
Author(s):  
Yu-Jia Wang ◽  
Henry Sung-Ching Wong ◽  
Chung-Che Wu ◽  
Yung-Hsiao Chiang ◽  
Wen-Ta Chiu ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Clinical Outcomes ◽  
Mild Traumatic Brain Injury ◽  
Sleep Disturbances ◽  
Neuropsychiatric Symptoms ◽  
Functional Roles ◽  
Control Subjects ◽  
Bioinformatics Databases ◽  
Anxiety Depression

Abstract Background Insulin-like growth factor 1 (IGF-1) is an important pleiotropic hormone that exerts neuroprotective and neuroreparative effects after a brain injury. However, the roles of IGF-1 variants in mild traumatic brain injury (mTBI) are not yet fully understood. This study attempted to elucidate the effects of IGF-1 variants on the risk and neuropsychiatric outcomes of mTBI. Methods Based on 176 recruited mTBI patients and 1517 control subjects from the Taiwan Biobank project, we first compared the genotypic distributions of IGF-1 variants between the two groups. Then, we analyzed associations of IGF-1 variants with neuropsychiatric symptoms after mTBI, including anxiety, depression, dizziness, and sleep disturbances. Functional annotation of IGF-1 variants was also performed through bioinformatics databases. Results The minor allele of rs7136446 was over-represented in mTBI patients compared to community-based control subjects. Patients carrying minor alleles of rs7136446 and rs972936 showed more dizziness and multiple neuropsychiatric symptoms after brain injury. Conclusions IGF-1 variants were associated with the risk and neuropsychiatric symptoms of mTBI. The findings highlight the important role of IGF-1 in the susceptibility and clinical outcomes of mTBI.

Incidence of Posttraumatic Stress Disorder and Mild Traumatic Brain Injury in Burned Service Members: Preliminary Report

2008 ◽  
Vol 64 (Supplement) ◽  
pp. S200-S206 ◽  
Author(s):  
Kathryn M. Gaylord ◽  
Douglas B. Cooper ◽  
Janyna M. Mercado ◽  
Jan E. Kennedy ◽  
Linda H. Yoder ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Posttraumatic Stress Disorder ◽  
Brain Injury ◽  
Posttraumatic Stress ◽  
Mild Traumatic Brain Injury ◽  
Preliminary Report ◽  
Stress Disorder ◽  
Service Members

scholarly journals Persistent alterations in cerebrovascular reactivity in response to hypercapnia following pediatric mild traumatic brain injury

2020 ◽  
Vol 40 (12) ◽  
pp. 2491-2504 ◽  
Author(s):  
Andrew B Dodd ◽  
Hanzhang Lu ◽  
Christopher J Wertz ◽  
Josef M Ling ◽  
Nicholas A Shaff ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Processing Speed ◽  
Sleep Disturbances ◽  
Chronic Phase ◽  
Blood Oxygen Level Dependent ◽  
Cerebrovascular Reactivity ◽  
Post Injury ◽  
End Tidal

Much attention has been paid to the effects of mild traumatic brain injury (mTBI) on cerebrovascular reactivity in adult populations, yet it remains understudied in pediatric injury. In this study, 30 adolescents (12–18 years old) with pediatric mTBI (pmTBI) and 35 age- and sex-matched healthy controls (HC) underwent clinical and neuroimaging assessments during sub-acute (6.9 ± 2.2 days) and early chronic (120.4 ± 11.7 days) phases of injury. Relative to controls, pmTBI reported greater initial post-concussion symptoms, headache, pain, and anxiety, resolving by four months post-injury. Patients reported increased sleep issues and exhibited deficits in processing speed and attention across both visits. In grey-white matter interface areas throughout the brain, pmTBI displayed increased maximal fit/amplitude of a time-shifted end-tidal CO2 regressor to blood oxygen-level dependent response relative to HC, as well as increased latency to maximal fit. The alterations persisted through the early chronic phase of injury, with maximal fit being associated with complaints of ongoing sleep disturbances during post hoc analyses but not cognitive measures of processing speed or attention. Collectively, these findings suggest that deficits in the speed and degree of cerebrovascular reactivity may persist longer than current conceptualizations about clinical recovery within 30 days.

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