scholarly journals 572. Poly(2-Dimethylaminoethyl Methacrylate)-Functionalized Graphene Oxide Nanoflakes for Efficient siRNA Delivery

2013 ◽  
Vol 21 ◽  
pp. S220
Keyword(s):  
Graphene Oxide ◽  
Sirna Delivery ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide ◽  
Dimethylaminoethyl Methacrylate

Dual-functionalized graphene oxide for enhanced siRNA delivery to breast cancer cells

2016 ◽  
Vol 147 ◽  
pp. 315-325 ◽  
Author(s):  
Rana Imani ◽  
Wei Shao ◽  
Samira Taherkhani ◽  
Shahriar Hojjati Emami ◽  
Satya Prakash ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Graphene Oxide ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Sirna Delivery ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide

scholarly journals Microencapsulated Multi-functionalized Graphene Oxide Equipped With Chloroquine for Efficient and Sustained Sirna Delivery

2021 ◽  
Author(s):  
Rana Imani ◽  
Satya Prakash ◽  
Hojatollah Vali ◽  
John F. Presley ◽  
Shahab Faghihi
Keyword(s):  
Graphene Oxide ◽  
Cellular Uptake ◽  
Sirna Delivery ◽  
Layer By Layer ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide ◽  
Lysosomal Ph ◽  
Intracellular Targeting ◽  
Lysosomotropic Agent ◽  
Layer Coating

Abstract A multi-functionalized graphene oxide (GO)-based carrier with conjugation of aminated-polyethylenglycole (PEG-diamine), octaarginine (R8) and folic acid (FA), which also contains chloroquine (CQ), a lysosomotropic agent, is introduced. The cellular uptake mechanisms and intracellular targeting of FA functionalized nanocarriers are examined. The localized releases of CQ and siRNA intracellular delivery are evaluated. Microencapsulation of the nanocarrier complexed with genes in layer-by-layer coating of alginate micro-beads is also investigated. The covalently co-conjugated FA with PEG and R8 provides a stable formulation with increased cellular uptake compared to FA-free carrier. The CQ-equipped nanocarrier shows a 95% release of CQ at lysosomal pH. The localized release of the drug inside the lysosomes is verified which accelerates the cargo discharge into cytoplasm.

Cellular Delivery of siRNA Using Poly(2-dimethylaminoethyl methacrylate)- Functionalized Graphene Oxide Nano-Wrap

2018 ◽  
Vol 26 (12) ◽  
pp. 1115-1122 ◽  
Author(s):  
Jung Eun Lee ◽  
Kyuri Lee ◽  
Jeong A. Nam ◽  
Aesun Kim ◽  
So Young Lee ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Functionalized Graphene ◽  
Cellular Delivery ◽  
Functionalized Graphene Oxide ◽  
Dimethylaminoethyl Methacrylate

scholarly journals Functionalized graphene oxide for anti-VEGF siRNA delivery: preparation, characterization and evaluation in vitro and in vivo

RSC Advances ◽  
2017 ◽  
Vol 7 (33) ◽  
pp. 20553-20566 ◽  
Author(s):  
Lulu Ren ◽  
Yifan Zhang ◽  
Chunying Cui ◽  
Yanzhao Bi ◽  
Xu Ge
Keyword(s):  
Graphene Oxide ◽  
Tumor Growth ◽  
Tumor Targeting ◽  
Sirna Delivery ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide ◽  
System P ◽  
Targeting Delivery

GO–PLL–SDGR/VEGF-siRNA inhibits tumor growth as a tumor targeting delivery system.

Polymer Functionalized Graphene Oxide: A Versatile Nanoplatform for Drug/Gene Delivery

2015 ◽  
Vol 19 (18) ◽  
pp. 1828-1837 ◽  
Author(s):  
George V. Theodosopoulos ◽  
Panayiotis Bilalis ◽  
Georgios Sakellariou
Keyword(s):  
Graphene Oxide ◽  
Gene Delivery ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide
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