Dual-Functionalized Graphene Oxide Based siRNA Delivery System for Implant Surface Biomodification with Enhanced Osteogenesis

2017 ◽  
Vol 9 (40) ◽  
pp. 34722-34735 ◽  
Author(s):  
Li Zhang ◽  
Qing Zhou ◽  
Wen Song ◽  
Kaimin Wu ◽  
Yumei Zhang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Delivery System ◽  
Sirna Delivery ◽  
Functionalized Graphene ◽  
Implant Surface ◽  
Functionalized Graphene Oxide ◽  
Sirna Delivery System

A tumor-targeting drug delivery system based on cyclic NGR-modified, combretastatin A4-loaded, functionalized graphene oxide nanosheets

RSC Advances ◽  
2016 ◽  
Vol 6 (72) ◽  
pp. 68134-68140 ◽  
Author(s):  
Fang Ding ◽  
Fanhong Wu ◽  
Qingqing Tian ◽  
Lingling Guo ◽  
Jing Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Targeting ◽  
Functionalized Graphene ◽  
Graphene Oxide Nanosheets ◽  
Functionalized Graphene Oxide ◽  
Combretastatin A4

Graphene oxide has shown great potential in drug delivery.

Dual-functionalized graphene oxide for enhanced siRNA delivery to breast cancer cells

2016 ◽  
Vol 147 ◽  
pp. 315-325 ◽  
Author(s):  
Rana Imani ◽  
Wei Shao ◽  
Samira Taherkhani ◽  
Shahriar Hojjati Emami ◽  
Satya Prakash ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Graphene Oxide ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Sirna Delivery ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide

scholarly journals Microencapsulated Multi-functionalized Graphene Oxide Equipped With Chloroquine for Efficient and Sustained Sirna Delivery

2021 ◽  
Author(s):  
Rana Imani ◽  
Satya Prakash ◽  
Hojatollah Vali ◽  
John F. Presley ◽  
Shahab Faghihi
Keyword(s):  
Graphene Oxide ◽  
Cellular Uptake ◽  
Sirna Delivery ◽  
Layer By Layer ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide ◽  
Lysosomal Ph ◽  
Intracellular Targeting ◽  
Lysosomotropic Agent ◽  
Layer Coating

Abstract A multi-functionalized graphene oxide (GO)-based carrier with conjugation of aminated-polyethylenglycole (PEG-diamine), octaarginine (R8) and folic acid (FA), which also contains chloroquine (CQ), a lysosomotropic agent, is introduced. The cellular uptake mechanisms and intracellular targeting of FA functionalized nanocarriers are examined. The localized releases of CQ and siRNA intracellular delivery are evaluated. Microencapsulation of the nanocarrier complexed with genes in layer-by-layer coating of alginate micro-beads is also investigated. The covalently co-conjugated FA with PEG and R8 provides a stable formulation with increased cellular uptake compared to FA-free carrier. The CQ-equipped nanocarrier shows a 95% release of CQ at lysosomal pH. The localized release of the drug inside the lysosomes is verified which accelerates the cargo discharge into cytoplasm.

scholarly journals Functionalized graphene oxide for anti-VEGF siRNA delivery: preparation, characterization and evaluation in vitro and in vivo

RSC Advances ◽  
2017 ◽  
Vol 7 (33) ◽  
pp. 20553-20566 ◽  
Author(s):  
Lulu Ren ◽  
Yifan Zhang ◽  
Chunying Cui ◽  
Yanzhao Bi ◽  
Xu Ge
Keyword(s):  
Graphene Oxide ◽  
Tumor Growth ◽  
Tumor Targeting ◽  
Sirna Delivery ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide ◽  
System P ◽  
Targeting Delivery

GO–PLL–SDGR/VEGF-siRNA inhibits tumor growth as a tumor targeting delivery system.

Aptamer-functionalized graphene oxide for highly efficient loading and cancer cell-specific delivery of antitumor drug

2014 ◽  
Vol 2 (24) ◽  
pp. 3849-3859 ◽  
Author(s):  
Yimei Lu ◽  
Ping Wu ◽  
Yajing Yin ◽  
Hui Zhang ◽  
Chenxin Cai
Keyword(s):  
Graphene Oxide ◽  
Cancer Cell ◽  
Anticancer Drug ◽  
Delivery System ◽  
Drug Loading ◽  
Functionalized Graphene ◽  
Cell Type ◽  
Functionalized Graphene Oxide ◽  
Cell Type Specific ◽  
Efficient Loading

A novel anticancer drug loading and cell-specific delivery system based on cell-type-specific aptamer-functionalized graphene oxide is reported.

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