368 The relationship between endothelin-1 and inflammatory cytokines levels and stress capacity in patients with heart failure

2004 ◽  
Vol 3 (1) ◽  
pp. 94
Author(s):  
J NESSLER
Keyword(s):  
Heart Failure ◽  
Inflammatory Cytokines ◽  
Endothelin 1 ◽  
Patients With Heart Failure ◽  
The Relationship

P2263Prognostic impact of perceived social isolation in patients with heart failure

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
T Ikeda ◽  
K Iwatsu ◽  
K Matsumura ◽  
H Ashikawa ◽  
K Takabayashi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Social Isolation ◽  
Roc Curve ◽  
Negative Impact ◽  
Roc Curve Analysis ◽  
Rehospitalization Rate ◽  
Kaplan Meier ◽  
Patients With Heart Failure ◽  
Perceived Social Isolation ◽  
The Relationship

Abstract Background Perceived social isolation (SI), the subjective sense of feelings of loneliness or isolation, has a negative impact on health outcomes, particularly in older adults. Although SI may also contribute to poor prognosis in patients with HF, evidence on the relationship between SI and outcomes in patients with HF is limited. Purpose The aim of this study was to investigate the relationship between SI and hospital readmission in patients with HF. Methods This study was a single center prospective cohort study. We consecutively enrolled 203 patients (mean age 72.9±11.7) who admitted for acute HF or exacerbation of chronic HF. At hospital discharge, we assessed perceived SI by using Lubben Social Network Scale - 6 (LSNS-6). Lower scores in LSNS-6 represents greater SI. Study outcome was rehospitalization for worsening HF within 180 days after discharge. We selected the optimal cutoff point of LSNS-6 that predict a worse outcome by the receiver operating characteristic (ROC) curve analysis. We investigate the association between SI and 180-days HF rehospitalization by using Cox proportional-hazard models, controlling for potential confounding factors. Results During follow up, A total of 40events (19.7%) were observed. The optimal cut-off point of LSNS-6 score was 17 points (the area under the ROC curve: 0.62, p<0.05, sensitivity: 82.5%, specificity 42.4%). Kaplan-Meier survival curves showed that those patients with greater SI (LSNS-6≤17) presented significantly higher HF rehospitalization rate (Figure). After adjusting for several pre-existing prognostic factors, LSNS-6≤17 was independently associated with HF rehospitalization (hazard ratio2.15,95% confidence interval 1.00–4.89). Conclusion The present study shows that SI is a independent predictor of HF rehospitalization in patients with HF. Assessing SI in the clinical practice with a brief screening tool may help identify patients with heart failure at greater risk of rehospitalization.

Effect of adrenomedullin on the production of endothelin-1 and on its vasoconstrictor action in resistance arteries: evidence for a receptor-specific functional interaction in patients with heart failure

2001 ◽  
Vol 101 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Chris HILLIER ◽  
Mark C. PETRIE ◽  
Michael P. LOVE ◽  
Fiona JOHNSTON ◽  
Margaret R. MACLEAN ◽  
...  
Keyword(s):  
Heart Failure ◽  
Hill Coefficient ◽  
Receptor Interaction ◽  
Resistance Arteries ◽  
Functional Interaction ◽  
High Potassium ◽  
Endothelin 1 ◽  
Patients With Heart Failure ◽  
Small Resistance ◽  
The Hill

Endothelin-1 (ET-1) and adrenomedullin (ADM) are both produced in the arterial wall, but have opposing biological actions. Evidence from experimental animals suggests a functional interaction between ET-1 and ADM. We have tested this in humans. Small resistance arteries were obtained from gluteal biopsies taken from patients with chronic heart failure (CHF) due to coronary heart disease (CHD), or with CHD and preserved ventricular function. The contractile responses to big ET-1 and to ET-1 in both sets of vessels were studied in the absence (control) and presence of ADM at 20 pmol/l (low ADM) or 200 pmol/l (high ADM), using wire myography. ADM did not affect the conversion of big ET-1 into ET-1 in vessels from patients with either CHD or CHF. Low ADM did not alter the contractile response to ET-1 in vessels from patients with CHF. Low ADM was not tested in vessels from patients with CHD, but high ADM did not affect this response in arteries from these patients. High ADM did, however, significantly reduce the vasoconstrictor effect of ET-1 in vessels from patients with CHF. The maximum response, as a percentage of the response to high potassium, was 199% (S.E.M. 25%) in the control experiments (n = 14), 205% (27%) in the low-ADM (n = 7) studies and 150% (17%) in the high-ADM (n = 6) experiments (P < 0.001). Furthermore, the Hill coefficient increased from 0.57±0.05 in the absence of ADM to 1.16±0.15 in the high-ADM experiments, indicating that ADM at 200 pmol/l specifically antagonized one receptor type in vessels from patients with CHF. We conclude that there is a one-site receptor interaction between ADM and ET-1 that is specific for vessels from patients with CHF. This functional interaction between ADM and ET-1 in resistance arteries may be of pathophysiological importance in CHF.

The relationship between health literacy and self-care in patients with heart failure

2021 ◽  
pp. 1-10
Author(s):  
Katie Nesbitt ◽  
Huiyun Du ◽  
Paul Nolan ◽  
Susie Cartledge ◽  
Parichat Wonggom ◽  
...  
Keyword(s):  
Heart Failure ◽  
Health Literacy ◽  
Patient Group ◽  
Care Management ◽  
Self Care ◽  
Randomised Control Trial ◽  
Adequate Health Literacy ◽  
Patients With Heart Failure ◽  
Literacy Knowledge ◽  
The Relationship

Background/Aims Research has shown that health literacy can influence an individual's ability to practise self-care, particularly for patients with heart failure. This study aimed to assess health literacy and its relationship with heart failure knowledge and self-care practices in this patient group. Methods An observational sub-study was conducted with the data from a large randomised control trial that evaluated the relationship between patients' health literacy, general literacy, knowledge of heart failure and self-care. Results A total of 36 participants were recruited, of which 33 (89.9%) had adequate levels of health literacy. Health literacy was positively associated with heart failure knowledge. However, 67.7% of participants with adequate health literacy were found to have inadequate levels of self-care management. Conclusions Health literacy may facilitate better heart failure knowledge, but it does not necessarily lead to improved self-care management in patients with heart failure. This suggest that clinicians need to put more emphasis on translating knowledge into behavioural changes for self-care in this patient group.

scholarly journals Race Moderates the Relationship Between Perceived Social Support and Self-care Confidence in Patients With Heart Failure

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Lakeshia Cousin ◽  
Andrew Bugajski ◽  
Harleah Buck ◽  
Terry Lennie ◽  
Misook Lee Chung ◽  
...  
Keyword(s):  
Heart Failure ◽  
Social Support ◽  
Perceived Social Support ◽  
Self Care ◽  
Patients With Heart Failure ◽  
The Relationship

The Most and the Least Performed Self-Care Behaviors Among Patients With Heart Failure in Jordan

2018 ◽  
Vol 29 (2) ◽  
pp. 108-116 ◽  
Author(s):  
Loai Issa Tawalbeh ◽  
Ahmed Mohammad Al-Smadi ◽  
Mohammed AlBashtawy ◽  
Maen AlJezawi ◽  
Mohamad Jarrah ◽  
...  
Keyword(s):  
Heart Failure ◽  
Low Income ◽  
Self Care ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Traditional Treatment ◽  
Patients With Heart Failure ◽  
Low Salt ◽  
Cross Sectional Design ◽  
The Relationship

Assessing self-care is important aspects among patients with heart failure. However, few studies were conducted to assess self-care among patients with heart failure in Jordan. Therefore, this study aimed to assess the most and the least performed maintenance self-care behaviors and to examine the relationship between maintenance self-care behaviors and selected sociodemographics. A cross-sectional design utilizing a convenience sample of 226 patients with heart failure was used. The maintenance self-care mean was 53.89 and considered below the clinical target level (≥70). Asking for low salt item and performing physical exercises were the most performed self-care behaviors, while “trying to avoid getting sick” and “checking ankles for swelling” were the least performed self-care behaviors. Limited self-care behaviors indicated the need to implement cardiac education that may improve self-care behaviors. Cardiac education should target mainly patients with low income, low educational level, elderly, living alone, unemployed, and who are using traditional treatment.

scholarly journals The relationship between serum adiponectin and prognosis in patients with heart failure

2013 ◽  
Vol 114 (08) ◽  
pp. 455-459 ◽  
Author(s):  
S. Sokhanvar ◽  
M. Sheykhi ◽  
S. Mazlomzade ◽  
L. Taran ◽  
Z. Golmohammadi
Keyword(s):  
Heart Failure ◽  
Serum Adiponectin ◽  
Patients With Heart Failure ◽  
The Relationship

scholarly journals Mediation effect of depressive symptoms in the relationship between perceived control and wellbeing in patients with heart failure and their partners

2018 ◽  
Vol 17 (6) ◽  
pp. 527-534 ◽  
Author(s):  
Maria Liljeroos ◽  
Anna Strömberg ◽  
Kristofer Årestedt ◽  
Misook L Chung
Keyword(s):  
Mental Health ◽  
Heart Failure ◽  
Depressive Symptoms ◽  
Health Status ◽  
Perceived Control ◽  
Self Care ◽  
Mental Health Status ◽  
Mediation Effect ◽  
Patients With Heart Failure ◽  
The Relationship

Background: As treatment has improved, patients with heart failure live longer, and the care mostly takes place at home with partners providing the main assistance. Perceived control over heart failure is important in managing self-care activities to maintain health in patients and their family. Depressive symptoms are associated with impaired health status in patients with heart failure and their family. However, there is limited knowledge about how depressive symptoms affect the relationship between health status and perceived control over heart failure in patients with heart failure and their cohabiting partners. Aim: The aim of this study was to examine whether the relationship between perceived control and health status (i.e. mental and physical) was mediated by depressive symptoms in patients with heart failure and their partners. Methods: In this secondary data analysis, we included 132 heart failure patients and 132 partners who completed measures of depressive symptoms (the Beck depression inventory II), perceived control (the control attitude scale), and physical and mental health status (the short form-36) instruments. The mediation effect of depression was examined using a series of multiple regression in patients and their family caregivers separately. Results: We found a mediator effect of depressive symptoms in the relationship between perceived control and mental health status in both patients and partners. The relationship between perceived control and physical health status was mediated by depressive symptoms in the patients, not in the partners. Conclusion: Efforts to improve self-care management and maintenance by targeting perceived control may be more effective if depressive symptoms are also effectively managed.

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