CD28 co-stimulation regulates the effect of transforming growth factor-β1 on the proliferation of naı̈ve CD4+ T cells

2003 ◽  
Vol 3 (2) ◽  
pp. 233-245 ◽  
Author(s):  
James L Sung ◽  
Jack T Lin ◽  
James D Gorham
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
Cd4 T Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1

scholarly journals Autophagy Improves the Immunosuppression of CD4+T Cells by Mesenchymal Stem Cells Through Transforming Growth Factor-β1

2016 ◽  
Vol 5 (11) ◽  
pp. 1496-1505 ◽  
Author(s):  
Liangbin Gao ◽  
Shuizhong Cen ◽  
Peng Wang ◽  
Zhongyu Xie ◽  
Zhenhua Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factor ◽  
Cd4 T Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1

scholarly journals Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4+T cells partly via transforming growth factor-β1

2016 ◽  
Vol 187 (1) ◽  
pp. 113-123 ◽  
Author(s):  
A. E. Anderson ◽  
D. J. Swan ◽  
O. Y. Wong ◽  
M. Buck ◽  
O. Eltherington ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Dendritic Cells ◽  
Growth Factor ◽  
Vitamin D3 ◽  
Cd4 T Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Tolerogenic Dendritic Cells

OR.55. Transforming Growth Factor-beta is Crucial for the Differentiation and Regulation of Interleukin 9-producing Human CD4+T Cells

2009 ◽  
Vol 131 ◽  
pp. S24
Author(s):  
Gaelle Beriou ◽  
Cristina Costantino ◽  
Clare Baecher-Allan ◽  
David Hafler
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Cd4 T Cells ◽  
Transforming Growth Factor ◽  
Growth Factor Beta ◽  
Interleukin 9

scholarly journals A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 ◽  
Vol 183 (6) ◽  
pp. 2669-2674 ◽  
Author(s):  
F Powrie ◽  
J Carlino ◽  
M W Leach ◽  
S Mauze ◽  
R L Coffman
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
Cd4 T Cells ◽  
Transforming Growth Factor ◽  
Th2 Cells ◽  
Tgf Beta ◽  
T Helper ◽  
Cd4 Cells ◽  
Helper Type

A T helper type 1 (Th1)-mediated colitis with similarities to inflammatory bowel disease in humans developed in severe combined immunodeficiency mice reconstituted with CD45RB(high) CD4+ splenic T cells and could be prevented by cotransfer of CD45RB(low) CD4+ T cells. Inhibition of this Th1 response by the CD45RB(low) T cell population could be reversed in vivo by an anti-transforming growth factor (TGF) beta antibody. Interleukin (IL) 4 was not required for either the differentiation of function of protective cells as CD45RB(low) CD4+ cells from IL-4-deficient mice were fully effective. These results identify a subpopulation of peripheral CD4+ cells and TGF-beta as critical components of the natural immune regulatory mechanism, which prevents the development of pathogenic Th1 responses in the gut, and suggests that this immunoregulatory population is distinct from Th2 cells.

A Unique Subset of CD4+CD25highFoxp3+ T Cells Secreting Interleukin-10 and Transforming Growth Factor-β1 Mediates Suppression in the Tumor Microenvironment

2007 ◽  
Vol 13 (15) ◽  
pp. 4345-4354 ◽  
Author(s):  
Laura Strauss ◽  
Christoph Bergmann ◽  
Miroslaw Szczepanski ◽  
William Gooding ◽  
Jonas T. Johnson ◽  
...  
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
Tumor Microenvironment ◽  
Transforming Growth Factor ◽  
Interleukin 10 ◽  
Transforming Growth Factor Β1

T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin-12 and interferon-γ and is inhibited by transforming growth factor-β

1994 ◽  
Vol 24 (4) ◽  
pp. 793-798 ◽  
Author(s):  
Edgar Schmitt ◽  
Petra Hoehn ◽  
Christoph Huels ◽  
Sigrid Goedert ◽  
Norbert Palm ◽  
...  
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
Cd4 T Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Interferon Γ ◽  
Interleukin 12 ◽  
T Helper ◽  
Helper Type

scholarly journals All-trans retinoic acid and rapamycin synergize with transforming growth factor-β1 to induce regulatory T cells but confer different migratory capacities

2013 ◽  
Vol 94 (5) ◽  
pp. 981-989 ◽  
Author(s):  
Siddharth Jhunjhunwala ◽  
Leo C. Chen ◽  
Erin E. Nichols ◽  
Angus W. Thomson ◽  
Giorgio Raimondi ◽  
...  
Keyword(s):  
T Cells ◽  
Retinoic Acid ◽  
Growth Factor ◽  
Regulatory T Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

scholarly journals The interleukin-10 inducing effect of transforming growth factor-β on human naive CD4+ T cells from cord blood is restricted to the TH1 subset

2006 ◽  
Vol 147 (2) ◽  
pp. 352-358
Author(s):  
B. Kapitein ◽  
M. M. Tiemessen ◽  
W. M. Liu ◽  
A. G. Van Ieperen-van Dijk ◽  
M. O. Hoekstra ◽  
...  
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
Cord Blood ◽  
Cd4 T Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Interleukin 10
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