308: Depression and anxiety score changes after elexacaftor/tezacaftor/ivacaftor: University of Cincinnati adult CF center experience

Background:Knee osteoarthritis is considered to be one of the most common causes of functional impairment, which affects the quality of life of patients leading to severe mood disorders. Our goal is to evaluate the frequency of depression and anxiety in patients with knee osteoarthritis.Objectives:Evaluate the frequency of depression and anxiety in patients with knee osteoarthritis.Methods:This is a cross-sectional study over a period of 7 months from February to August 2016, including consecutively patients who consulted in the Rheumatology department at Mahdia university hospital for knee osteoarthritis. We evaluated for each patient a validated version of HAD “Hospital Anxiety and Depression scale”. This score includes 14 items each one rated from 0 to 3 and two components including depression and anxiety.Results:We included in our study 66 patients (56 women and 10 men) with an average age of 60.3 years [40-90 years]. Knee osteoarthritis was bilateral in 56.1% of cases. The examination found limited mobility of the knee in 45.5% and flessum in 13.8% of cases. Standard radiography showed stage 1 knee osteoarthritis in 4.5%, stage 2 in 31.8%, stage 3 in 56.1% and stage 4 in 7.6% of cases. All our patients were treated with analgesics, NSAIDs in 95.5%, local corticosteroid infiltrations in 43.9% and hyaluronic acid in 7.6% of cases.The mean visual analog scale(VAS)was 5.84 ±1.7 out of 10 [2-9]. The mean overall WOMAC index was 47.15±15.6 [12-82]. The average Lequesne index was 16.8±13.1, moderate disability was found in 3% of cases, significant disability in 6.1% of cases, very significant disability in 18.2% of cases and extreme disability in 72.7% of cases. The mean depression score was 9.3±2.6 [4-16], with 24.6% of the patients had no depressive symptomatology (score ≤7), 40% had doubtful depressive symptomatology (score between 8 and 10) and 35.4% of them had certain depressive symptomatology (score ≥11).The mean anxiety score was 8.88 ± 4 [0-19], 33.3% of patients had no anxiety symptoms (score ≤ 7), 34.8% had doubtful anxiety (score between 8 and 10) and 31.8% had certain anxiety (score ≥11). The statistical study found a significant correlation between the depression score and WOMAC score, but we did not find an association with age, sex, radiological stage, mobility limitation and VAS. Regarding anxiety, there was a correlation with age, WOMAC score and female gender. On the other hand, there was no correlation with VAS, Lequesne score, radiological stage and limitation of mobility.Conclusion:Although knee osteoarthritis appears to be a benign pathology, its impact can be severe, including depression and anxiety, which are mainly influenced by the degree of functional disability. Hence psychological care is sometimes necessary in these chronic degenerative diseases.Disclosure of Interests:None declared

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Depression and anxiety in an early rheumatoid arthritis inception cohort. associations with demographic, socioeconomic and disease features

RMD Open ◽

10.1136/rmdopen-2020-001376 ◽

2020 ◽

Vol 6 (3) ◽

pp. e001376

Author(s):

George E Fragoulis ◽

Jonathan Cavanagh ◽

Alistair Tindell ◽

Mohammad Derakhshan ◽

Caron Paterson ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Disease Activity ◽

Early Rheumatoid Arthritis ◽

Anxiety Score ◽

Anxiety And Depression ◽

Global Score ◽

Depression And Anxiety ◽

Inception Cohort ◽

Early Ra ◽

Younger Age

ObjectiveDepression and anxiety are not uncommon in Rheumatoid arthritis (RA). It is increasingly recognised that they are associated with high disease activity and worse disease outcomes. We aimed to examine the frequency of depression and anxiety in an early RA inception cohort and to explore associations with disease-related measures.MethodsThe Scottish Early Rheumatoid Arthritis inception cohort recruited newly diagnosed RA patients followed-up 6-monthly. Anxiety and depression were assessed using the hospital anxiety and depression scale. Associations with demographic characteristics and disease-related measures were examined at baseline, 6 months and 12 months.Results848 RA patients were included. The prevalence of anxiety and depression at baseline was 19.0% and 12.2%, respectively. Depression and anxiety scores correlated with DAS28 at all time-points (all p<0.0001). In multivariable linear regression, anxiety score at baseline was associated with younger age and Health Assessment Questionnaire (HAQ) score. Anxiety scores at 6 months and 12 months were associated with low body mass index (BMI), baseline anxiety score and current patient global score and HAQ. Depression score at baseline was associated with younger age, being single and HAQ, while depression scores at 6 months and 12 months were associated with male gender (only at 6 months), baseline anxiety and depression scores and current patient global score, HAQ and C-reactive protein (CRP) levels.ConclusionDepression and anxiety are associated with disease activity, worse functional status and other variables in early RA. There is a close relationship between CRP and depression but not anxiety.

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Proceedings of The Modern Language Association of America

PMLA ◽

10.1017/s0030812900130470 ◽

1935 ◽

Vol 50 (4) ◽

pp. 1343-1343

Keyword(s):

Modern Language Association ◽

Modern Language ◽

Local Committee ◽

Tuesday Morning ◽

University Of Cincinnati ◽

The University ◽

Plaza Hotel

The fifty-second meeting of the Modern Language Associationof America was held, on the invitation of the University of Cincinnati, at Cincinnati, Ohio, Monday, Tuesday, and Wednesday, December 30 and 31, 1935, and January 1, 1936. The Association headquarters were in the Netherland Plaza Hotel, where all meetings were held except those of Tuesday morning and afternoon. These took place at the University of Cincinnati. Registration cards at headquarters were signed by about 900, though a considerably larger number of members were in attendance. The Local Committee estimated the attendance at not less than 1400. This Committee consisted of Professor Frank W. Chandler, Chairman; Professor Edwin H. Zeydel; Professor Phillip Ogden; Mr. John J. Rowe (for the Directors); and Mr. Joseph S. Graydon (for the Alumni).

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Individual Differences and Hemispheric Asymmetry While Processing Emotional Words

Journal of Individual Differences ◽

10.1027/1614-0001/a000137 ◽

2014 ◽

Vol 35 (3) ◽

pp. 137-143 ◽

Cited By ~ 1

Author(s):

Lindsay M. Niccolai ◽

Thomas Holtgraves

Keyword(s):

Individual Differences ◽

Hemispheric Asymmetry ◽

Past Research ◽

Decision Task ◽

Depression And Anxiety ◽

Hemispheric Differences ◽

Affective Valence ◽

Emotional Words ◽

Emotion Words ◽

The Right

This research examined differences in the perception of emotion words as a function of individual differences in subclinical levels of depression and anxiety. Participants completed measures of depression and anxiety and performed a lexical decision task for words varying in affective valence (but equated for arousal) that were presented briefly to the right or left visual field. Participants with a lower level of depression demonstrated hemispheric asymmetry with a bias toward words presented to the left hemisphere, but participants with a higher level of depression displayed no hemispheric differences. Participants with a lower level of depression also demonstrated a bias toward positive words, a pattern that did not occur for participants with a higher level of depression. A similar pattern occurred for anxiety. Overall, this study demonstrates how variability in levels of depression and anxiety can influence the perception of emotion words, with patterns that are consistent with past research.

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Dimensionality and Reliability Assessment of the Pain Patient Profile Questionnaire

European Journal of Psychological Assessment ◽

10.1027/1015-5759.24.1.22 ◽

2008 ◽

Vol 24 (1) ◽

pp. 22-26 ◽

Cited By ~ 1

Author(s):

Brian E. McGuire ◽

Michael J. Hogan ◽

Todd G. Morrison

Keyword(s):

Self Report ◽

Pain Patient ◽

Fit Indices ◽

Depression And Anxiety ◽

Oblique Rotation ◽

Pain Experience ◽

Patient Profile ◽

Adequate Representation ◽

Pain Patients ◽

Report Measure

Abstract. Objective: To factor analyze the Pain Patient Profile questionnaire (P3; Tollison & Langley, 1995 ), a self-report measure of emotional distress in respondents with chronic pain. Method: An unweighted least squares factor analysis with oblique rotation was conducted on the P3 scores of 160 pain patients to look for evidence of three distinct factors (i.e., Depression, Anxiety, and Somatization). Results: Fit indices suggested that three distinct factors, accounting for 32.1%, 7.0%, and 5.5% of the shared variance, provided an adequate representation of the data. However, inspection of item groupings revealed that this structure did not map onto the Depression, Anxiety, and Somatization division purportedly represented by the P3. Further, when the analysis was re-run, eliminating items that failed to meet salience criteria, a two-factor solution emerged, with Factor 1 representing a mixture of Depression and Anxiety items and Factor 2 denoting Somatization. Each of these factors correlated significantly with a subsample's assessment of pain intensity. Conclusion: Results were not congruent with the P3's suggested tripartite model of pain experience and indicate that modifications to the scale may be required.

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