Liquid chromatographic determination of the plasma concentrations of cefotaxime and desacetylcefotaxime in plasma of critically ill patients

2004 ◽  
Vol 811 (2) ◽  
pp. 159-163 ◽  
Author(s):  
M ROSSEEL ◽  
K VANDEWOUDE
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Plasma Concentrations ◽  
Chromatographic Determination ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Gas-liquid chromatographic determination of bupivacaine and lidocaine in plasma.

1978 ◽  
Vol 24 (9) ◽  
pp. 1573-1575 ◽  
Author(s):  
E Zylber-Katz ◽  
L Granit ◽  
M Levy
Keyword(s):  
Methylene Chloride ◽  
Plasma Concentrations ◽  
Extraction Procedure ◽  
Internal Standard ◽  
Chromatographic Determination ◽  
Liquid Chromatographic Method ◽  
Extraction Scheme ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Abstract A modified gas-liquid chromatographic method for determining plasma concentrations of bupivacaine and lidocaine is described, with cyclizine as an internal standard. The extraction procedure requires no solvent evaporation, thus overcoming the problem of drug volatility. Concentrations as low as 0.1 mg/liter can be determined. The plasma sample is made alkaline and extracted into n-hexane, re-extracted into a small volume of an aqueous acid phase, and finally extracted into 50 microliter of methylene chloride after alkalinization. The final extract is assayed by gas chromatography on a 5% OV-17 column. The extraction scheme of the present method eliminates interferences by endogenous plasma constituents.

Simultaneous Liquid Chromatographic Determination of Selected Tricyclic Antidepressants and Co-Administered Benzodiazepines

2016 ◽  
Vol 12 (6) ◽  
pp. 560-567
Author(s):  
Marwa F. Mansour ◽  
Ehab F. El-Kady ◽  
Mona M. Abd El-Moety ◽  
Nabawia M. El-Guindi ◽  
Ann Van Schepdael ◽  
...  
Keyword(s):  
Tricyclic Antidepressants ◽  
Chromatographic Determination ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Gas-Liquid Chromatographic Determination of Technical Chlordane Residues in Food Crops: Interpretation of Analytical Data

1975 ◽  
Vol 58 (5) ◽  
pp. 1051-1061
Author(s):  
William P Cochrane ◽  
James F Lawrence ◽  
Young W Lee ◽  
Ronald B Maybury ◽  
Brian P Wilson
Keyword(s):  
Field Experiments ◽  
Stationary Phases ◽  
Analytical Data ◽  
Chromatographic Determination ◽  
Electron Capture Detection ◽  
Food Crops ◽  
Liquid Chromatographic Determination ◽  
Consistent Method ◽  
Liquid Chromatographic

Abstract An interlaboratory investigation of technical chlordane residues in food crops was carried out to determine the most practical and consistent method of reporting results. Using a technical chlordane reference standard, 8 gas chromatographic stationary phases were studied for their resolution capabilities. The best separations were obtained with SE-30 and its OV-1 equivalent. Using these columns and electron capture detection, potatoes and carrots from supervised field experiments were analyzed in duplicate and quantitated by using 4 methods of calculation. The data were statistically treated to determine the precision and bias for each method. Also, 1 sample was analyzed in duplicate on 2 different occasions by 6 laboratories to substantiate the initial conclusions. Based on the criterion of high precision it is suggested that a comparison of total area under the chromatogram of the sample with total area of a standard technical chlordane be the method of quantitation. Only peaks which are common to both standard and sample have any significance in this type of calculation.

Liquid Chromatographic Determination of Amiodarone Hydrochloride and Related Compounds in Raw Materials and Tablets

1994 ◽  
Vol 77 (6) ◽  
pp. 1447-1453 ◽  
Author(s):  
Pauline M Lacrok ◽  
Norman M Curran ◽  
Wing-Wah Sy ◽  
Dennis K J Goreck ◽  
Pierre Thibault ◽  
...  
Keyword(s):  
Raw Materials ◽  
Chromatographic Determination ◽  
Raw Material ◽  
Liquid Chromatographic Method ◽  
Limit Of Quantitation ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic ◽  
Amiodarone Hydrochloride ◽  
Related Compounds

Abstract A liquid chromatographic method for the determination of amiodarone hydrochloride and 10 related compounds in drug raw material and for assay of drug in tablets was developed. The method specifies a 3 jxm Hypersil nitrile column (150 × 4.6 mm), a mobile phase of 1 + 1 acetonitrile–ammonium acetate buffer (0.1 M adjusted to pH 6.0 with 0.1 M acetic acid), a flow rate of 1 mL/min, and detection at 240 nm. The lower limit of quantitation of the related compounds is 0.02% or less. Drug contents in 2 raw material samples were 100.1 and 99.9% and ranged from 98.2 to 99.4% in 3 tablet formulations. Impurity levels in 2 samples of raw material from different manufacturers were ca 0.4%. The presence of 3 of the known related compounds in these samples was confirmed by liquid chromatographymass spectrometry. The method applied to raw materials was evaluated by a second laboratory and found to be satisfactory.

Liquid chromatographic determination of alliin in garlic and garlic products

1988 ◽  
Vol 455 ◽  
pp. 271-277 ◽  
Author(s):  
Emiko Mochizuki ◽  
Akira Nakayama ◽  
Yoshimi Kitada ◽  
Koichi Saito ◽  
Hiroyuki Nakazawa ◽  
...  
Keyword(s):  
Chromatographic Determination ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic
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