22 Serum Free Testosterone Levels Emerging as a Biomarker of Sexual Dysfunction Secondary to SSRI's and SDA's in Both Genders

2011 ◽  
Vol 4 ◽  
pp. S47
Author(s):  
P. Khairkar ◽  
A. Basak ◽  
G. Bang ◽  
P. Tiple ◽  
V. Jain ◽  
...  
Keyword(s):  
Sexual Dysfunction ◽  
Free Testosterone ◽  
Serum Free ◽  
Testosterone Levels

scholarly journals Interest of the androgen deficiency in aging males (ADAM) questionnaire for the identification of hypogonadism in elderly community-dwelling male volunteers

2004 ◽  
Vol 151 (3) ◽  
pp. 355-360 ◽  
Author(s):  
A Tancredi ◽  
JY Reginster ◽  
F Schleich ◽  
G Pire ◽  
P Maassen ◽  
...  
Keyword(s):  
High Sensitivity ◽  
Free Testosterone ◽  
Community Dwelling ◽  
Androgen Deficiency ◽  
Operating Characteristics ◽  
Serum Free ◽  
Testosterone Levels ◽  
A Value ◽  
Elderly Males

OBJECTIVE: To date, serum free testosterone measurement is considered to be the gold standard for the diagnosis of hypogonadism in elderly males but it is not available to all subjects suspected of a decrease in testicular function. Therefore, we evaluated whether the Androgen Deficiency in Aging Males (ADAM) questionnaire, in its original or in a modified 'quantitative' version (qADAM), could be used as a surrogate to biochemical determinations for the identification of hypogonadism in elderly males. METHODS: 5028 men, aged 50-70 years, spontaneously consulting for the assessment of their gonadal function were studied. ADAM and qADAM, allocating a value of 1 point for any positive answer to each of the 10 questions of the ADAM test, were assessed for their ability to discriminate between males with free testosterone levels below or above 70 ng/l. RESULTS: The sensitivity and specificity of the ADAM score were 81% and 21.6% respectively. The use of ADAM resulted in an appropriate classification of our population in normal or hypogonadal subjects in 44.5% of the cases. The area under the receiver operating characteristics (ROC) curve for the qADAM (0.529) revealed a highly marginal interest of this quantitative approach compared with the original scoring system. CONCLUSIONS: The ADAM test has a high sensitivity to identify aging males with low free testosterone levels. However, due to its lack of specificity, this test cannot be used as a surrogate to serum free testosterone testing for the identification of androgen deficiency in elderly, community-dwelling males.

scholarly journals Serum free testosterone and asthma, asthma hospitalisations and lung function in British adults

Thorax ◽  
2020 ◽  
Vol 75 (10) ◽  
pp. 849-854 ◽  
Author(s):  
Yueh-Ying Han ◽  
Qi Yan ◽  
Ge Yang ◽  
Wei Chen ◽  
Erick Forno ◽  
...  
Keyword(s):  
Lung Function ◽  
Smoking Status ◽  
Free Testosterone ◽  
Cross Sectional Study ◽  
Serum Estradiol ◽  
Cross Sectional ◽  
Lower Odds ◽  
Serum Free ◽  
Testosterone Levels ◽  
The Uk

ObjectiveWe examined the relation between serum-free testosterone and asthma, wheeze, asthma hospitalisations and lung function in older adults.DesignCross-sectional study.SettingUK.Participants256 419 adults aged 40 to 69 years, recruited from 2006 to 2010.Main outcome measuresMultivariable logistic or linear regression was used for the analysis of free testosterone and physician-diagnosed asthma, current wheeze, asthma hospitalisations and lung function measures, which was adjusted for serum estradiol, smoking status and other covariates.ResultsFree testosterone levels above the lowest quartile (Q1) were significantly associated with lower odds of asthma in both women (adjusted OR (aOR) for Q4 (the highest quartile) versus Q1=0.67, 95% CI=0.64 to 0.71) and men (aOR for Q4 versus Q1=0.87, 95% CI=0.82 to 0.91). Among subjects with asthma, free testosterone levels above Q1 were significantly associated with lower odds of current wheeze in women (aOR range=0.78 to 0.87), and free testosterone levels in Q4 were associated with lower odds of current wheeze in men (aOR for Q4 versus Q1=0.86, 95% CI=0.77 to 0.95). Among women with asthma, free testosterone levels in Q4 were also associated with lower odds of ≥1 asthma hospitalisation. Among men, free testosterone was positively associated with FEV1 and FVC. Among women, free testosterone was negatively and weakly associated with FVC.ConclusionIn a large study of British adults, elevated free testosterone levels are associated with lower odds of asthma and current wheeze in women and men, lower odds of asthma hospitalisations in women, and higher FEV1 and FVC in men.Dissemination to participants, and related patient and public communitiesThe results of the study will be linked to the UK Biobank website.

Serum free testosterone levels are positively correlated with skeletal muscle mass in older women aged over 75 years

2019 ◽  
Vol 19 (5) ◽  
pp. 460-461 ◽  
Author(s):  
Mitsutaka Yakabe ◽  
Taro Kojima ◽  
Taisaku Okumura ◽  
Shinya Takiyama ◽  
Yumi Umeda‐Kameyama ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Older Women ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Free Testosterone ◽  
Serum Free ◽  
Testosterone Levels

scholarly journals Serum free testosterone levels in polycystic ovarian syndrome patients and its correlation with clinical hyperandrogenism in Pakistan

2020 ◽  
Vol 14 (03) ◽  
pp. 132-135
Author(s):  
Tahir Ullah Khan ◽  
Naseer Nazeer Memon ◽  
Amna Riaz ◽  
Zohaib Ahmed Khan ◽  
Sundus Mariyum Haroon ◽  
...  
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovary ◽  
Free Testosterone ◽  
Reproductive Age ◽  
Fisher Exact Test ◽  
Polycystic Ovaries ◽  
Cross Sectional ◽  
Serum Free ◽  
Testosterone Levels ◽  
Ovarian Syndrome

Background: Polycystic ovary syndrome (PCOS) is the most frequent pathology among women of reproductive age characterized by menstrual irregularities, hyperandrogenism and polycystic ovaries on ultrasound. Evidence suggests that high androgen levels are the fundamental factor in the pathogenesis of PCOS. The objectives of the present study was to determine serum free testosterone levels in polycystic ovarian syndrome patients, and observe its correlation with clinical hyperandrogenism. Patients and methods: This cross-sectional study was conducted at Jinnah Allama Iqbal Institute of Diabetes and Endocrinology Lahore, Pakistan from 15th May 2019 to 15th November 2019. The study included 140 patients of PCOS diagnosed as per Rotterdam criteria. Serum testosterone levels were determined in these patients by ELISA method. Ferriman-Gallwey (FG) score was used to assess severity of clinical hyperandrogenism in the form of hirsutism. Patients were categorized into three groups, mild (FG score 8-15), moderate (FG score 15-25) and severe (FG score >25). Correlation between clinical (hirsutism) and biochemical hyperandrogenism (serum free testosterone levels) was assessed using Fisher exact test. Data was analyzed using SPSS version 25. Results: Biochemical hyperandrogenism in the form of raised free testosterone levels was present in 46 (32.9%) PCOS patients. Out of 12 patients having Ferriman Gallwey score >25, 10 (83.3%) had biochemical hyperandrogenism. Out of 70 patients having Ferriman Gallwey score 15-25, 22 (31.4%) had biochemical hyperandrogenism whereas out of 58 patients having Ferriman Gallwey score 8-15, only 14 (24.1%) patients had biochemical hyperandrogenism. Conclusion: Prevalence of biochemical hyperandrogenism in PCOS patients in our studied population was significantly low when compared to the population studied worldwide making it less reliable as diagnostic tool in this part of the world. Also there was significant positive correlation between free testosterone levels and degree of hirsutism which means that diagnostic accuracy of free testosterone in PCOS patients is considerably high in those having clinical hyperandrogenism.

Free Testosterone Level And Quality of Cauda Epididymis Sperm of Local Rabbit That Given Commercial Feed Supplemented By Cod Fish Liver Oil

2016 ◽  
Vol 2 (3) ◽  
pp. 1
Author(s):  
Ni Gusti Ayu Manik Ermayanti ◽  
I Gusti Lanang Oka ◽  
I Gede Mahardika ◽  
I Putu Suyadnya
Keyword(s):  
Testosterone Level ◽  
Sperm Quality ◽  
Free Testosterone ◽  
Fish Liver ◽  
Testosterone Levels ◽  
Commercial Feed ◽  
One Way Anova ◽  
Free Testosterone Level ◽  
Range Test

This study was intended to determine the free testosterone levels and sperm quality of local rabbit that was given commercial feed supplemented cod fish liver oil.  The experiment design that was used in this research was Complete Random Design (CRD) with four experiments of feed, i.e. commercial feed without cod fish liver oil (R-0) as control, commercial feed + 1,5% cod fish liver oil (R-1), commercial feed + cod fish liver oil 3% (R-2), commercial feed + cod fish liver oil 4,5% (R-3). The each experiment included eight rabbits and feed experiment was given starting by 13 weeks to 26 weeks years old. The variable that observed was free testosterone level and sperm quality of local rabbit. The data that was obtained to be analyzed with One Way Anova and if its contrast was done more test with Duncan’s Multiple Range Test (DMRT). The result of this research was to show that supplementation of cod fish liver oil in commercial feed was to show the result that a real distinction of (P<0, 05) towards free testosterone level and sperm quality of local rabbit.

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