OAB-019: CRISPR screens with single-cell transcriptome readout reveal potential mechanisms of response to natural killer cell treatment in multiple myeloma

2021 ◽  
Vol 21 ◽  
pp. S12-S13
Author(s):  
Sara Gandolfi ◽  
Olli Dufva ◽  
Jani Huuhtanen ◽  
Olga Dashevsky ◽  
Jay Klievink ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Natural Killer Cell ◽  
Single Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome

scholarly journals Plasma cells in multiple myeloma express a natural killer cell- associated antigen: CD56 (NKH-1; Leu-19)

Blood ◽  
1990 ◽  
Vol 76 (2) ◽  
pp. 377-382 ◽  
Author(s):  
B Van Camp ◽  
BG Durie ◽  
C Spier ◽  
M De Waele ◽  
I Van Riet ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Plasma Cells ◽  
Killer Cell ◽  
Neoplastic Tissue ◽  
Aggressive Disease ◽  
Reactive Plasma ◽  
Gut Mucosa ◽  
Cd56 Expression

Abstract Bone marrow samples from 55 patients with multiple myeloma (MM) and 23 patients with monoclonal gammopathy of undertermined significance (MGUS) were evaluated with a broad panel of monoclonal antibodies. Plasma cells from 78% (43/55) of patients with MM strongly expressed the natural killer cell antigen CD56 (NKH-1, Leu-19). Of the 23 patients with MGUS, none showed strong CD56 reactivity, although three had weak reactivity in less than 20% of plasma cells. Myeloma cells expressing CD56 did not coexpress the CD57 or CD16 antigens. Patients with CD56-positive plasma cells had both indolent and aggressive disease. However, the 12 CD56-negative patients had predominantly aggressive disease with an unexpected preponderance of kappa Bence Jones only myeloma (5/10[50%] evaluable patients). Polyclonal plasma cells from non-neoplastic tissue sites (normal bone marrows, lymph nodes, tonsillar biopsies, and gut-mucosa biopsies) showed a near absence of CD56. We conclude that isolated, strong CD56 expression is common in MM, but not in MGUS or reactive plasma cells. The potential biologic importance of CD56 positivity in myeloma is reviewed.

scholarly journals Transfection of chimeric anti-CD138 gene enhances natural killer cell activation and killing of multiple myeloma cells

2013 ◽  
Vol 8 (2) ◽  
pp. 297-310 ◽  
Author(s):  
Hua Jiang ◽  
Wenhao Zhang ◽  
Peipei Shang ◽  
Hui Zhang ◽  
Weijun Fu ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Cell Activation ◽  
Killer Cell ◽  
Myeloma Cells ◽  
Natural Killer Cell Activation

Natural Killer cell transcriptome during primary EBV infection and EBV associated Hodgkin Lymphoma in children—A preliminary observation

Immunobiology ◽  
2020 ◽  
Vol 225 (3) ◽  
pp. 151907 ◽  
Author(s):  
Alka M ◽  
Shatakshee Chatterjee ◽  
Parchure A ◽  
Mahantesh S ◽  
Sravanthi Davuluri ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Hodgkin Lymphoma ◽  
Killer Cell ◽  
Preliminary Observation ◽  
Ebv Infection ◽  
Cell Transcriptome

Modulation of natural killer cell effector functions through lenalidomide/dasatinib and their combined effects against multiple myeloma cells

2013 ◽  
Vol 55 (1) ◽  
pp. 168-176 ◽  
Author(s):  
Isabel Jungkunz-Stier ◽  
Michael Zekl ◽  
Thorsten Stühmer ◽  
Hermann Einsele ◽  
Ruth Seggewiss-Bernhardt
Keyword(s):  
Multiple Myeloma ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Combined Effects ◽  
Myeloma Cells ◽  
Effector Functions ◽  
Cell Effector
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