Antihyperglycemic, antioxidant and hypolipidemic effect of Punica granatum L flower extract in streptozotocin induced diabetic rats

Antidiabetic action of ethanolic extracts of seed and rind of Punica granatum L. was evaluated on alloxan-induced diabetic albino rats. Both the extracts, each at a dose of 200mg/kg/d, were administered orally for two weeks to alloxan-induced diabetic rats. Blood glucose was estimated every week for two consecutive weeks. For evaluation of probable mechanism of action of the extracts, glycogen estimation was carried out in liver, heart and skeletal muscle and effect on adrenaline-induced hyperglycemia was observed. Both the extracts significantly (p<0.05) reduced the rise in blood glucose induced by alloxan, with the rind extract exhibiting significantly (p<0.05) better activity than seed extract. Both the extracts also produced significant (p<0.05) increase in liver glycogen and significantly (p<0.05) reduced adrenaline-induced hyperglycemia. These results support strong antidiabetic action in favor of P. granatum seed and rind extractsKey words: Punica granatum L.; Ethanolic extracts; Antidiabetic; Alloxan. DOI: 10.3329/sjps.v2i1.5810Stamford Journal of Pharmaceutical Sciences Vol.2(1) 2009: 14-21

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Hypoglycemic and Antioxidative Effects of Pomegranate (Punica granatum L.) Juice in Streptozotocin Induced Diabetic Rats

Pakistan Journal of Nutrition ◽

10.3923/pjn.2014.567.572 ◽

2014 ◽

Vol 13 (10) ◽

pp. 567-572 ◽

Cited By ~ 2

Author(s):

Prasetyastuti . ◽

Mochammad Willy Prat Anthony ◽

Nuha Aulia Rahman ◽

Ngadikun . ◽

Sunarti .

Keyword(s):

Punica Granatum ◽

Diabetic Rats ◽

Antioxidative Effects ◽

Punica Granatum L

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PHYTOCHEMICAL CONSTITUENTS, ANTIOXIDANT ACTIVITY AND ACUTE ORAL TOXICITY OF POMEGRANATE (PUNICA GRANATUM L.) FRUIT PEEL EXTRACT

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2019.4.1 ◽

2019 ◽

pp. 7-14

Author(s):

Hai Trieu Ly ◽

Tuan Anh Vo ◽

Viet Hong Phong Nguyen ◽

Thi My Sa Pham ◽

Bich Thao Lam ◽

...

Keyword(s):

Antioxidant Activity ◽

Gallic Acid ◽

Radical Scavenging ◽

Dry Weight ◽

Punica Granatum ◽

Acute Oral Toxicity ◽

Oral Toxicity ◽

Fruit Peel ◽

Total Polyphenol ◽

Punica Granatum L

Background: The natural antioxidants have an important role in the prevention of many diseases. The aim of study is to investigate phytochemical components, antioxidant activity and acute oral toxicity of Pomegranate (Punica granatum L.) fruit peel (PFP) extract. Materials and methods: Phytochemicals of PFP were determined by qualitative chemical tests, thin layer chromatography, total polyphenol and flavonoid contents. The PFP extract was evaluated for antioxidant activity by DPPH assay and MDA assay. In vivo acute oral toxicity test was conducted using Karber-Behrens method to determine LD50. Results: Results illustrated that PFP mainly contains flavonoids, alkaloids, tannins, triterpenes, saponins, and coumarins. PFP extract exhibited the total polyphenol and flavonoid contents with 189.97 mg gallic acid equivalent/g dry weight and 9.42 mg quercetin equivalent/g dry weight, respectively. The DPPH free radical scavenging and anti-lipid peroxidation activities of PFP extract were expressed with IC50 value of 4.80 μg/mL and 0.38 μg/ mL, sequentially. Simultaneously, the Dmax (the maximum dose administered to mice that no toxicity was observed) of PFP extract was determined to be 21.28 g/kg, equivalent to 35.64 g dried herb. Conclusion: The PFP extract is relatively safe and revealed high antioxidant activity. Key words: Punica granatum L.; polyphenols; flavonoids; gallic acid; quercetin; antioxidant activity; acute oral toxicity

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