Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women

Abstract Objectives The study aim was to assess bone mineral density (BMD) and bone turnover in pre- and postmenopausal women with severe obesity. Additionally, we explored the association between soft tissue body composition and BMD according to menopausal status. Methods This is a cross-sectional study conducted in pre- (n = 37) and postmenopausal (n = 22) morbid obese (BMI >40 kg/cm2) women. Body composition and BMD at different sites (lumbar spine, proximal femur and forearm) were assessed by dual energy X-ray absorptiometry (DXA). Biochemical markers of bone metabolism (serum CTX and osteocalcin) and serum 25(OH)D were also measured. Differences between pre- and postmenopausal women were analyzed by Student´s t-test. Body composition [lean mass, visceral (VAT) and subcutaneous (SAT) adipose tissue] and other potential factors associated with BMD were investigated by multiple regression. Results BMD at all sites evaluated was similar in pre- and postmenopausal women (P > 0.05). Also, no differences between groups were observed for bone turnover markers (P > 0.05). In postmenopausal women, years after menopause was inversely associated with BMD at total body (β = −0.010, P < 0.01) and total femur (β = −0.009, P < 0.05). Serum 25(OH)D was also associated with total femur BMD (β = 0.008, P < 0.01) in postmenopausal women. Lean mass was not associated with BMD in both groups. VAT was directly associated with lumbar spine BMD in postmenopausal women (β = 0.135, P < 0.05). Conclusions Our results suggest that severe obesity may weaken the impact of menopause on bone mass and turnover. Also, soft tissue body composition appears to poorly influence bone density in these women. Funding Sources Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ, Grant number E26/110.764/2013 for FFB).

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Klotho Gene Polymorphisms Associated With Bone Density of Aged Postmenopausal Women

Journal of Bone and Mineral Research ◽

10.1359/jbmr.2002.17.10.1744 ◽

2002 ◽

Vol 17 (10) ◽

pp. 1744-1751 ◽

Cited By ~ 131

Author(s):

Ken-Ichi Kawano ◽

Naoshi Ogata ◽

Mathias Chiano ◽

Helen Molloy ◽

Patrick Kleyn ◽

...

Keyword(s):

Bone Density ◽

Postmenopausal Women ◽

Gene Polymorphisms ◽

Klotho Gene

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Volumetric bone density of the lumbar spine is related to fat mass but not lean mass in normal postmenopausal women

Osteoporosis International ◽

10.1007/bf01622199 ◽

1994 ◽

Vol 4 (6) ◽

pp. 362-367 ◽

Cited By ~ 77

Author(s):

I. R. Reid ◽

M. C. Evans ◽

R. W. Ames

Keyword(s):

Lumbar Spine ◽

Bone Density ◽

Postmenopausal Women ◽

Fat Mass ◽

Lean Mass ◽

Volumetric Bone Density

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Effect of 6 months of whole body vibration on lumbar spine bone density in postmenopausal women: a randomized controlled trial [Corrigendum]

Clinical Interventions in Aging ◽

10.2147/cia.s68890 ◽

2014 ◽

pp. 945

Author(s):

Meng-Chih Lee ◽

Chung-Liang Lai ◽

Shiuan-Yu Tseng ◽

Chung-Nan Chen ◽

Wan-Chun Liao ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Lumbar Spine ◽

Bone Density ◽

Postmenopausal Women ◽

Controlled Trial ◽

Whole Body Vibration ◽

Whole Body ◽

Body Vibration ◽

Randomized Controlled

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Effect of 6 months of whole body vibration on lumbar spine bone density in postmenopausal women: a randomized controlled trial

Clinical Interventions in Aging ◽

10.2147/cia.s53591 ◽

2013 ◽

pp. 1603 ◽

Cited By ~ 3

Author(s):

Meng-Chih Lee ◽

Chung-Liang Lai ◽

Shiuan-Yu Tseng ◽

Chung-Nan Chen ◽

Wan-Chun Liao ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Lumbar Spine ◽

Bone Density ◽

Postmenopausal Women ◽

Controlled Trial ◽

Whole Body Vibration ◽

Whole Body ◽

Body Vibration ◽

Randomized Controlled

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The effect of body mass index on bone mineral density in postmenopausal women

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20184403 ◽

2018 ◽

Vol 6 (11) ◽

pp. 3482 ◽

Cited By ~ 1

Author(s):

Yusuf Serdar Gürlek ◽

Ahmet Kalaycıoğlu ◽

Beril Gurlek

Keyword(s):

Lumbar Spine ◽

Waist Circumference ◽

Bone Density ◽

Postmenopausal Women ◽

Positive Impact ◽

Mineral Density ◽

T Score ◽

Healthy Female ◽

Negative Effect ◽

History Of

Background: The aim of this study was to evaluate the association between BMI and BMD among postmenopausal women.Methods: A total of 121 healthy female patients, aged 65.67±8.59 years, previously menopaused, were enrolled. Subjects were divided into five subgroups according to their BMI. History of fracture and BMD were recorded and compared between groups.Results: Among the 121 subjects, 77 (63.6%) individuals had a normal BMD, 32 (26.4%) had osteopenia, and 12 (9.9%) were diagnosed with osteoporosis. Mean of waist circumference was 96.1±8.52cm. The prevalence of fractures was 29.8% in this study. A simple correlation analysis revealed that waist circumference was negatively related to lumbar spine BMD (r= -0.374, p=0.03) and lumbar spine BMD T score (r= -0,352 p=0.002) whereas body weight was positively related to BMD of lumbar spine BMD (r=0.41, p=0.0001) and lumbar spine BMD T score (r=0,31 p=0.001). Age and years since menopause (YSM) were negatively correlated with BMD and T score (p=0.001, p=0.0001, respectively).Conclusions: Even though higher BMI seems to have positive impact on bone density thanks to hormonal and mechanical reasons, increased waist circumference is a sign of a metabolic syndrome and systemic inflammation which are known as having negative effect on bone density. Therefore, postmenopausal women specifically with abdominal obesity should be evaluated for osteoporosis.

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