Sources of Modeling Software

2021 ◽  
pp. 451-454
Keyword(s):  
Modeling Software

Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

2018 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Transdermal Drug Delivery ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Modeling Software ◽  
Deposition Modeling ◽  
3D Printed ◽  
Microfabrication Technique ◽  
Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

Microstructures in Elastic Media

1994 ◽  
Author(s):  
Nhan Phan-Thien ◽  
Sangtae Kim
Keyword(s):  
Computational Methods ◽  
High Performance ◽  
Chemical Engineering ◽  
Elliptic Partial Differential Equations ◽  
Parallel Computers ◽  
Computational Algorithms ◽  
Applied Physics ◽  
Advanced Students ◽  
Particulate Solids ◽  
Modeling Software

This monograph describes various methods for solving deformation problems of particulate solids, taking the reader from analytical to computational methods. The book is the first to present the topic of linear elasticity in mathematical terms that will be familiar to anyone with a grounding in fluid mechanics. It incorporates the latest advances in computational algorithms for elliptic partial differential equations, and provides the groundwork for simulations on high performance parallel computers. Numerous exercises complement the theoretical discussions, and a related set of self-documented programs is available to readers with Internet access. The work will be of interest to advanced students and practicing researchers in mechanical engineering, chemical engineering, applied physics, computational methods, and developers of numerical modeling software.

scholarly journals Cryo-EM model validation recommendations based on outcomes of the 2019 EMDataResource challenge

2021 ◽  
Vol 18 (2) ◽  
pp. 156-164 ◽  
Author(s):  
Catherine L. Lawson ◽  
Andriy Kryshtafovych ◽  
Paul D. Adams ◽  
Pavel V. Afonine ◽  
Matthew L. Baker ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Structure Data ◽  
Model Evaluation ◽  
Data Bank ◽  
High Accuracy ◽  
Atomic Resolution ◽  
Software Developers ◽  
Data Archives ◽  
Modeling Software

AbstractThis paper describes outcomes of the 2019 Cryo-EM Model Challenge. The goals were to (1) assess the quality of models that can be produced from cryogenic electron microscopy (cryo-EM) maps using current modeling software, (2) evaluate reproducibility of modeling results from different software developers and users and (3) compare performance of current metrics used for model evaluation, particularly Fit-to-Map metrics, with focus on near-atomic resolution. Our findings demonstrate the relatively high accuracy and reproducibility of cryo-EM models derived by 13 participating teams from four benchmark maps, including three forming a resolution series (1.8 to 3.1 Å). The results permit specific recommendations to be made about validating near-atomic cryo-EM structures both in the context of individual experiments and structure data archives such as the Protein Data Bank. We recommend the adoption of multiple scoring parameters to provide full and objective annotation and assessment of the model, reflective of the observed cryo-EM map density.

scholarly journals Characteristics, potentials, and limitations of open-source Simulink projects for empirical research

2021 ◽  
Author(s):  
Alexander Boll ◽  
Florian Brokhausen ◽  
Tiago Amorim ◽  
Timo Kehrer ◽  
Andreas Vogelsang
Keyword(s):  
Open Source ◽  
Empirical Research ◽  
Code Generation ◽  
Quality Analysis ◽  
Academic Context ◽  
Early Validation ◽  
Modeling Software ◽  
Development Context ◽  
The One ◽  
Automated Code Generation

AbstractSimulink is an example of a successful application of the paradigm of model-based development into industrial practice. Numerous companies create and maintain Simulink projects for modeling software-intensive embedded systems, aiming at early validation and automated code generation. However, Simulink projects are not as easily available as code-based ones, which profit from large publicly accessible open-source repositories, thus curbing empirical research. In this paper, we investigate a set of 1734 freely available Simulink models from 194 projects and analyze their suitability for empirical research. We analyze the projects considering (1) their development context, (2) their complexity in terms of size and organization within projects, and (3) their evolution over time. Our results show that there are both limitations and potentials for empirical research. On the one hand, some application domains dominate the development context, and there is a large number of models that can be considered toy examples of limited practical relevance. These often stem from an academic context, consist of only a few Simulink blocks, and are no longer (or have never been) under active development or maintenance. On the other hand, we found that a subset of the analyzed models is of considerable size and complexity. There are models comprising several thousands of blocks, some of them highly modularized by hierarchically organized Simulink subsystems. Likewise, some of the models expose an active maintenance span of several years, which indicates that they are used as primary development artifacts throughout a project’s lifecycle. According to a discussion of our results with a domain expert, many models can be considered mature enough for quality analysis purposes, and they expose characteristics that can be considered representative for industry-scale models. Thus, we are confident that a subset of the models is suitable for empirical research. More generally, using a publicly available model corpus or a dedicated subset enables researchers to replicate findings, publish subsequent studies, and use them for validation purposes. We publish our dataset for the sake of replicating our results and fostering future empirical research.

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