Chronic and refractory mood disorders in childhood and adolescence

Author(s):  
Adelita Segovia ◽  
Kelly N. Botteron ◽  
Barbara Geller
1985 ◽  
Vol 147 (5) ◽  
pp. 517-523 ◽  
Author(s):  
Ian Goodyer ◽  
Israel Kolvin ◽  
Sonia Gatzanis

A sample of children and adolescents (n = 157) attending a child psychiatry outpatient clinic with conduct or emotional disturbance were compared with community controls (n = 76) for the number and type of recent life events. A Life Events Schedule for children and adolescents was developed and used as a semi-structured interview. Four clinical groups were identified according to their predominant presenting symptoms (conduct, mild mood, severe mood, or somatic). An excess of events carrying a severe degree of negative impact was found for all four groups, compared with matched controls. Eleven classes of events were examined: there is a suggestion that two classes (marital/family, accident/illness) may be more important for conduct and mild mood disorders, and that a further class (permanent separations, termed exits) may be more important for somatic and severe mood disorders.


2012 ◽  
Vol 53 (4) ◽  
pp. 448-464 ◽  
Author(s):  
Jason Schnittker ◽  
Michael Massoglia ◽  
Christopher Uggen

Psychiatric disorders are unusually prevalent among current and former inmates, but it is not known what this relationship reflects. A putative causal relationship is contaminated by assorted influences, including childhood disadvantage, the early onset of most disorders, and the criminalization of substance use. Using the National Comorbidity Survey Replication ( N = 5692), we examine the relationship between incarceration and psychiatric disorders after statistically adjusting for multidimensional influences. The results indicate that (1) some of the most common disorders found among former inmates emerge in childhood and adolescence and therefore predate incarceration; (2) the relationships between incarceration and disorders are smaller for current disorders than lifetime disorders, suggesting that the relationship between incarceration and disorders dissipates over time; and (3) early substance disorders anticipate later incarceration and other psychiatric disorders simultaneously, indicating selection. Yet the results also reveal robust and long-lasting relationships between incarceration and certain disorders, which are not inconsequential for being particular. Specifically, incarceration is related to subsequent mood disorders, related to feeling “down,” including major depressive disorder, bipolar disorder, and dysthymia. These disorders, in turn, are strongly related to disability, more strongly than substance abuse disorders and impulse control disorders. Although often neglected as a health consequence of incarceration, mood disorders might explain some of the additional disability former inmates experience following release, elevating their relevance for those interested in prisoner reintegration.


2016 ◽  
pp. 269-280
Author(s):  
Brandon D. Johnson ◽  
Anne F. Bird ◽  
Vilma Gabbay

Author(s):  
Gin S. Malhi

Despite the advent of many treatments, mood disorders remain a considerable burden. Tracing their evolution points to inception early in life—birth, infancy, childhood, and adolescence, with full-blown debilitating syndromes eventuating as young adults and in later years. The inability to satisfactorily treat these illnesses, especially once established, has increasingly focused attention on early intervention and ideally prevention. For this, universal and targeted preventive strategies have been trialled that address various aspects of the emerging syndromes along their anticipated trajectories of illness. The success of these endeavours has been limited. The efficacy and effectiveness of targeted interventions are marginally superior to community-wide universal interventions, but in most cases, the benefits are modest and short-lived. This chapter discusses the preventive interventions that have been tested and implemented to date, with a view to identifying the factors contributing to these deficiencies. At the same time, alternative strategies that may be able to overcome these shortfalls are explored, with particular emphasis on the integration of neurobiological and neuropsychological components in prevention paradigms.


2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Hiroki Ishiguro ◽  
Naomi Honobe ◽  
Takefumi Suzuki ◽  
Mariko Tamai ◽  
Takaya Nakane

Ehlers-Danlos syndrome (EDS) comprises a series of rare hereditary connective tissue diseases characterized by musculoskeletal, skin, and cardiovascular involvements. EDS may be associated with physical as well as psychological pain that can lead to psychiatric problems. EDS imposes substantial psychological burden on patients, and recent large-scale studies have suggested that patients with EDS have a higher risk of mood disorders than the general population. To the best of our knowledge, we describe, for the first time, the cases of two Japanese patients with EDS complicated with mood disorders who secondarily developed transvestism that was judged strongly related to early stressful situations through childhood and adolescence. The first case was of a man in his mid-30s and the second of a woman in her late 20s. We report on detailed psychosocial data to further discuss the medical management and genetic counseling of such infrequent but challenging conditions. Physicians are advised to be aware of various potential psychological and psychiatric issues that may accompany EDS.


2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S37-S38
Author(s):  
Elena De la Serna ◽  
Daniel Ilzarbe ◽  
Gisela Sugranyes ◽  
Inmaculada Baeza ◽  
Dolores Moreno ◽  
...  

Abstract Background Having one parent diagnosed with a severe mental disorder is considered one of the main risk factors for developing that disorder in adulthood and it also increases the risk of a wide range of mental disorders in the offspring from early childhood and adolescence. The aim of this study is to analyze the prevalence of several psychopathological diagnoses, the presence of prodromal symptoms and global functioning in schizophrenia offspring (SZoff) or bipolar offspring (BDoff) compared to community control offspring (CCoff) at baseline and 2-year follow-up. Methods 41 SZoff, 97 BDoff and 107 CCoff between 7 and 17 years were included. Clinical assessment consisted of a clinical evaluation using the following instruments: structured interview KSADS-PL or SCID-I, semi-structured Interview for Prodromal Syndromes (SIPS) and the Children’s Global Assessment Scale (CGAS). To test between-group differences in DSM-IV diagnoses multilevel mixed-effect logistic regression models (categorical variables) or linear (continuous variables) regression models were conducted with group (SZoff, BDoff and CCoff), time (baseline or 2-year follow-up), interaction time x group, age, gender and socio-economic status as fixed variables. Results Significant differences between groups were found in any lifetime axis I disorder (F=8.720; p<0.001), mood disorders (F=4.774; p=0.009), anxiety disorders (F=4.368; p=0.013), ADHD (F=21.593; p<0.001), disruptive behavioral disorders (F=10.788; p<0.001) and comorbidity (F=5.588; P=0.004). Significant differences between groups were also found in the positive (F=6.088; p=0.003), negative (F=4.423; p=0.015), disorganized (F=3.866; p=0.024) and total (F=6.394; p= 0.002) sub-scales of the SOPS and CGAS (F=11.613;p<0.001). Interestingly, mood disorders were more prevalent in BDoff and disruptive disorders were more prevalent in SZoff. Prodromal symptoms were higher in SZoff compared to CCoff, while the BPoff group showed an intermediate pattern. Finally, global functioning was lower in the SZoff group compared to BDoff and CCoff. Discussion Screening patients’ children is clinically relevant since, as a group, they have an elevated risk of developing a psychiatric disorder and of experiencing their first symptoms during childhood and adolescence.


2020 ◽  
Vol 87 (9) ◽  
pp. S67-S68
Author(s):  
Mary Phillips ◽  
Alison Hipwell ◽  
Layla Banihashemi ◽  
Michele Bertocci ◽  
Jay Fournier ◽  
...  

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