Trait Anxiety, Neuroticism, and the Brain Basis of Vulnerability to Affective Disorder

2013 ◽  
pp. 553-574 ◽  
Author(s):  
Sonia Bishop ◽  
Sophie Forster
Keyword(s):  
Affective Disorder ◽  
Trait Anxiety ◽  
The Brain

scholarly journals A PRELIMINARY STUDY OF BIOLOGICAL ATTRIBUTED RISK FACTOR FOR ANXIETY AMONG ANXIOUS CHILDREN

2019 ◽  
Vol 4 (33) ◽  
pp. 209-222
Author(s):  
Chen Cheong Chen ◽  
Asmidawati Ashari ◽  
Rahimah Ibrahim ◽  
Wan Aliaa W. Sulaiman ◽  
Kian Yong Koo
Keyword(s):  
Risk Factors ◽  
Electrical Activity ◽  
Trait Anxiety ◽  
Significant Relationship ◽  
Anxiety Level ◽  
Anxiety Score ◽  
Brain Electrical Activity ◽  
Biological Risk ◽  
The Brain ◽  
Trait Anxiety Score

Anxiety disorders are chronic, disabling conditions that are distributed across the globe. Woefully, the consistent increase of prevalence rate had affected people across nations range from children to adults. Biological attributed risk factors had associated strongly with the early onset of anxiety during the childhood stage. This current research intended to study the biological risk factors of brain electrical activity, hereditary and gender effect on trait anxiety among anxious children. A total of 36 children, aged ranged from 8 to 13 years old with high trait anxiety level were recruited by using a purposive sampling method. Self- administered STAIC-T and STAIT were used to measure the trait anxiety level of children and parents respectively. Besides, neuroimaging of Quantitative Electroencephalogram (qEEG) brain mapping was administered to study the brain electrical activity and associated brain locations. Pearson’s Correlation was carried out in order to study the relationship between biological risk factors with trait anxiety level. Results showed that there is a significant relationship between parents’ trait anxiety score and children’s trait anxiety score. Preliminary findings indicated that the brain locations of Fp1, F4, F8, T3, and T4 showed a significant relationship with trait anxiety. In conclusion, hereditary and associated brain locations played a role in affecting the trait anxiety level of children and results in the biological vulnerability of anxiety since birth.

The brain structure and spontaneous activity baseline of the behavioral bias in trait anxiety

2016 ◽  
Vol 312 ◽  
pp. 355-361 ◽  
Author(s):  
Ping Yin ◽  
Meng Zhang ◽  
Xin Hou ◽  
Yafei Tan ◽  
Yixiao Fu ◽  
...  
Keyword(s):  
Spontaneous Activity ◽  
Trait Anxiety ◽  
Brain Structure ◽  
Behavioral Bias ◽  
The Brain

Tryptophan hydroxylase 2 in seasonal affective disorder: underestimated perspectives?

2015 ◽  
Vol 26 (6) ◽  
Author(s):  
Alexander V. Kulikov ◽  
Nina K. Popova
Keyword(s):  
Affective Disorder ◽  
Tryptophan Hydroxylase ◽  
Seasonal Affective Disorder ◽  
Recurrent Depression ◽  
Tryptophan Hydroxylase 2 ◽  
System Functioning ◽  
Brain Neurotransmitter ◽  
The Relationship ◽  
Rate Limiting ◽  
The Brain

AbstractSeasonal affective disorder (SAD) is characterized by recurrent depression occurring generally in fall/winter. Numerous pieces of evidence indicate the association of SAD with decreased brain neurotransmitter serotonin (5-HT) system functioning. Tryptophan hydroxylase 2 (TPH2) is the key and rate-limiting enzyme in 5-HT synthesis in the brain. This paper concentrates on the relationship between TPH2 activity and mood disturbances, the association between human

CSF Neuropeptides in Euthymic Bipolar Patients and Controls

1987 ◽  
Vol 150 (2) ◽  
pp. 208-212 ◽  
Author(s):  
Wade H. Berrettini ◽  
John I. Nurnberger ◽  
Robert L. Zerbe ◽  
Philip W. Gold ◽  
George P. Chrousos ◽  
...  
Keyword(s):  
Affective Disorder ◽  
Vasoactive Intestinal Peptide ◽  
Interstitial Space ◽  
Group Differences ◽  
Corticotrophin Releasing Factor ◽  
Trait Marker ◽  
Positive Correlations ◽  
Bipolar Patients ◽  
The Brain ◽  
Random Diffusion

Levels of vasopressin, somatostatin, neurotensin, vasoactive intestinal peptide, corticotrophin-releasing factor and adrenocorticotrophin in CSF were determined in lithium-treated and unmedicated euthymic bipolar patients and controls, in a search for a trait marker in affective disorder. No group differences in levels of these peptides were found. Highly significant positive correlations were found among these peptides (with the exception of neurotensin), suggesting that their presence in CSF is functionally significant, as opposed to the result of random diffusion from the interstitial space of the brain.

Pseudobulbar affective disorder, emotion and the brain

2017 ◽  
Vol 88 (10) ◽  
pp. 809-810
Author(s):  
Michael Swash ◽  
Michael R Trimble
Keyword(s):  
Affective Disorder ◽  
The Brain

The Biochemistry of Affective Disorders

1967 ◽  
Vol 113 (504) ◽  
pp. 1237-1264 ◽  
Author(s):  
Alec Coppen
Keyword(s):  
Affective Disorder ◽  
Clinical Condition ◽  
Affective Disorders ◽  
Biochemical Changes ◽  
Weight Of Evidence ◽  
Environmental Events ◽  
The Brain

The title of this review would be regarded by some psychiatrists as provocative; they would relegate the biochemical concomitants of depression and mania to a secondary position and deny that biochemical changes have any place in the aetiology of these conditions. However, in my view, the weight of evidence, although it is by no means conclusive, suggests that biochemical changes are most important in the aetiology of affective disorders. A biochemical aetiology implies that there are certain biochemical changes in the brain which need to be restored to normal before the patient's clinical condition will improve. This does not deny that psychological and environmental events may precipitate and maintain the biochemical events which in turn lead to the affective disorder. The study of these biochemical events is clearly at too early a stage for speculations about the interrelationship between environmental and endogenous elements to be fruitful; this study must wait until the biochemical aetiology is clearer than at present.

Brain Amines and Peptides—Their Relevance to Psychiatry

1979 ◽  
Vol 13 (4) ◽  
pp. 283-291 ◽  
Author(s):  
Graeme C. Smith ◽  
David Copolov
Keyword(s):  
Affective Disorder ◽  
Current Status ◽  
Experimental Conditions ◽  
Brain Amines ◽  
The Brain

The amine theory of affective disorder and the dopamine and endorphin theories of schizophrenia are controversial but heuristically valuable concepts that have emerged from the psychobiological revolution of the last decade. That revolution stemmed largely from the development of techniques for localizing and assaying neuroregulators and their receptors in the brain under normal, pathological and experimental conditions. The data thus obtained are reviewed here, and the current status of the emergent psychobiological hypotheses assessed.

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