scholarly journals 3469 Age and racial variation in the relation between blood lead level and asthma in children: Data from National Health and Nutrition Examination Survey 1999-2016

2019 ◽  
Vol 3 (s1) ◽  
pp. 32-33
Author(s):  
Magda Shaheen ◽  
Deyu Pan
Keyword(s):  
Young Children ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
Nutrition Examination Survey ◽  
Health And Nutrition ◽  
Asthma Status ◽  
Pb Exposure ◽  
Asthma In Children ◽  
Racial Ethnic

OBJECTIVES/SPECIFIC AIMS: Lead (Pb) exposure can seriously affect nervous system and kidney. Young children are vulnerable to Pb exposure. However, the role of low-level Pb exposure in asthma in children and the age and racial disparity is not well studied. The objectives are to examine the relation between Pb level and asthma status and to determine the age and racial/ethnic differences in this relation. METHODS/STUDY POPULATION: We analyzed data from National Health and Nutrition Examination Survey 1999-2016 for 22,885 children 1-15 years old. Asthma information was collected by questionnaire. Blood lead level was measured using mass spectrometry. The association between blood Pb level and asthma status was assessed by logistic regression after adjusting for children’ age, gender, race/ethnicity, insurance status, and source of care; household poverty, mother’s age and smoking status. Data were analyzed using Stata 14 considering design and sample weight and p<0.05 is statistically significant. RESULTS/ANTICIPATED RESULTS: Pb level was associated with asthma status (Adjusted Odds Ratio (AOR)=1.4, 95% Confidence Interval (CI) = 1.2-1.7, p < 0.001). Stratified analysis by age showed that blood Pb level is related to asthma only in children 1-5 years old (AOR = 1.3, 95% CI = 1.1-1.5, p = 0.004). There was no racial/ethnic difference in this association. DISCUSSION/SIGNIFICANCE OF IMPACT: Pb level is associated with asthma status in children especially young children. Health risk of low Pb is a concern. Preventive measures by reducing potential sources of Pb should be introduced early.

scholarly journals Decreases in Young Children Who Received Blood Lead Level Testing During COVID-19 — 34 Jurisdictions, January–May 2020

2021 ◽  
Vol 70 (5) ◽  
pp. 155-161
Author(s):  
Joseph G. Courtney ◽  
Stella O. Chuke ◽  
Kelly Dyke ◽  
Kimball Credle ◽  
Carolina Lecours ◽  
...  
Keyword(s):  
Young Children ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead

Lead Poisoning: From Screening to Primary Prevention

PEDIATRICS ◽  
1993 ◽  
Vol 92 (1) ◽  
pp. 176-183
Author(s):  
Keyword(s):  
Young Children ◽  
American Academy ◽  
Lead Poisoning ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
Impaired Hearing ◽  
American Academy Of Pediatrics ◽  
Lead Levels ◽  
Us Children

Knowledge of the extent and seriousness of childhood lead poisoning has vastly expanded since the last statement regarding lead poisoning by the American Academy of Pediatrics in 1987.1 Blood lead levels once thought to be safe have been shown to be associated with IQ deficits, behavior disorders, slowed growth, and impaired hearing.2 In fact, lead poisoning is, according to the Department of Health and Human Services, "the most important environmental health problem for young children."3 The rapid development of the scientific database requires recognition by physicians of the significance of effects at lower levels and a change in clinical practice. During the last 30 years the Centers for Disease Control and Prevention (CDC) has revised downward the definition of the blood level at which lead poisoning occurs from 60 µg/dL whole blood in the early 1960s, to 30 µg/dL in 1975, and 25 µg/dL in 1985. The 1991 CDC statement "Preventing Lead Poisoning in Young Children" recommended lowering the community intervention level to 10 µg/dL and setting several action levels (Table 1).2 In 1987 the American Academy of Pediatrics stated that lead levels greater than 25 µg/dL were unacceptable for children.1 The Academy now recognizes that impairment of cognitive function begins to occur at levels greater than 10 µg/dL, even though clinical symptoms are not seen. In the late 1970s, the average blood lead level for US children was 16 µg/dL.4 The mean blood lead level for US children has declined since 1976 due to the phaseout of lead in gasoline5 and the reduction of lead in food, and it is now between 4 and 6 µg/dL.6

Temporal pattern in the effect of postnatal blood lead level on intellectual development of young children

2000 ◽  
Vol 22 (6) ◽  
pp. 805-810 ◽  
Author(s):  
Lourdes Schnaas ◽  
Stephen J Rothenberg ◽  
Estela Perroni ◽  
Sandra Martı́nez ◽  
Carmen Hernández ◽  
...  
Keyword(s):  
Young Children ◽  
Temporal Pattern ◽  
Blood Lead Level ◽  
Intellectual Development ◽  
Lead Level ◽  
Blood Lead

scholarly journals Blood Lead Concentrations and Mortality in Korean Adults: the Korea National Health and Nutrition Examination Survey with Mortality Follow-Up

2020 ◽  
Vol 17 (18) ◽  
pp. 6898
Author(s):  
Garam Byun ◽  
Sera Kim ◽  
Soo-Yeon Kim ◽  
Dahyun Park ◽  
Min-Jeong Shin ◽  
...  
Keyword(s):  
National Health ◽  
Cancer Mortality ◽  
Lead Level ◽  
Blood Lead ◽  
Developed Countries ◽  
Korean Population ◽  
Nutrition Examination Survey ◽  
Health And Nutrition ◽  
Hazard Ratios ◽  
Risk Of Mortality

Previous studies have consistently reported an increase in mortality risk, even at low levels of blood lead. The average blood lead concentration in the Korean population has steadily decreased but is still higher than that of developed countries. The purpose of this study was to examine the associations between mortality and blood lead concentrations for adults in Korea. We used the Korea National Health and Nutrition Examination Survey (2008–2013) linked Cause of Death data, which are followed by 2018. A total of 7308 subjects who aged over 30 at the baseline examination were included in the analyses. Cox proportional hazard model was used to estimate the hazard ratios of mortality from non-accidental causes and cancer mortality. The estimated hazard ratios (95% CI) for comparison of the second and third tertile group with the lowest tertile group were 2.01 (1.20, 3.40) and 1.91 (1.13, 3.23) for non-accidental mortality and 3.42 (95% CI: 1.65, 7.08) and 2.27 (95% CI: 1.09, 4.70) for cancer mortality, respectively. The dose–response relationship also showed significant increase in the risk of mortality at blood lead level between 1.5 and 6.0 μg/dL. Our findings suggest that potent policies to lower lead exposure are required for the general Korean population.

scholarly journals The Department of Defense Blood Lead Level Survey Program for Young Children

1996 ◽  
Vol 161 (11) ◽  
pp. 687-690
Author(s):  
Edward Burkhalter ◽  
William Butler
Keyword(s):  
Young Children ◽  
Department Of Defense ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead

scholarly journals Association between blood lead level and risk of stroke in Korean adults: a cross-sectional study in the Korea National Health and Nutrition Examination Survey 2008–2013

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e035725
Author(s):  
Minkyeong Kim ◽  
Sang-Moon Yun ◽  
Jihyun Jeong ◽  
Chulman Jo ◽  
Young Ho Koh
Keyword(s):  
Blood Lead Level ◽  
Lead Concentration ◽  
Lead Level ◽  
Blood Lead ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
High Level ◽  
Level Group

ObjectivesAlthough lead is a potential risk factor for cardiovascular diseases such as stroke, research on this association in the Korean population remains limited. Therefore, we aimed to investigate the association between lead level and stroke in Korean adults.DesignA population-based cross-sectional study.SettingThe Korea National Health and Nutrition Examination Survey 2008–2013, which enrolled a representative sample of the Korean population.ParticipantsWe excluded participants younger than 20 years, missing weight data, pregnant or lactating, and missing blood lead and stroke data. A total of 11 510 participants were included in this analysis.Primary and secondary outcome measurementThe participants were classified by blood lead concentration into the low-level (≤2.189 µg/dL, n=5756) and high-level (>2.189 µg/dL, n=5754) groups. The main outcome, stroke, was assessed by information from physician diagnosis, prevalence of stroke or treatment for stroke. The ORs and 95% CIs were calculated to evaluate the association between blood lead level and stroke using multivariate logistic regression analysis.ResultsAlthough blood lead level was not significantly associated with stroke (OR: 1.30, 95% CI: 0.66–2.58) in the multivariate-adjusted model, in individuals with hypertension, the high-level group was 2.36-fold higher odds of stroke (OR: 2.36, 95% CI: 1.02–5.44) compared to that in the low-level group. No association was observed in individuals with normotension (OR: 0.42, 95% CI: 0.13–1.38, p for interaction=0.007).ConclusionThe association between blood lead concentration and stroke may be influenced by hypertension status. Our findings suggest the need for closer attention to lead exposure in patients with hypertension.

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