scholarly journals Gastric emptying and orocaecal transit time of meals containing lactulose or inulin in men

2010 ◽  
Vol 104 (4) ◽  
pp. 554-559 ◽  
Author(s):  
Miriam Clegg ◽  
Amir Shafat
Keyword(s):  
Gastric Emptying ◽  
Transit Time ◽  
Test Meal ◽  
Breath Test ◽  
Lag Phase ◽  
Half Time ◽  
Non Invasive ◽  
Male Volunteers ◽  
Transit Times ◽  
Orocaecal Transit Time

The H2 breath test is ideal for orocaecal transit time (OCTT) measurement, as it is non-invasive and inexpensive. Indigestible substrates added to a test meal are metabolised by the colonic bacteria, resulting in the production of H2 which is detected in end-exhalation breath. However, the substrates themselves can alter the transit times in the gastrointestinal tract. The aim of the present study is to compare OCTT and gastric emptying (GE) when lactulose in liquid (L-L), solid lactulose (L-S) and solid inulin (IN-S) are added to a test meal, and subsequently, to examine if inulin alters GE. Firstly, ten male volunteers were tested on three occasions. Volunteers ate a pancake breakfast containing 100 mg of 13C-octanoic acid and either 12 g of L-L, 12 g of L-S or 12 g of IN-S in a randomised order. Secondly, seven male volunteers were tested twice with meals containing either 12 g of IN-S or no substrate (NO-S). L-L induced the shortest OCTT (85·3 (sd 42·8) min) compared with L-S (162·4 (sd 62·6) min) and inulin (292·4 (sd 66·7) min; P = 0·007). GE half-time and lag phase (L-L: 61 (sd 9); L-S: 57 (sd 10); IN-S: 52 (sd 10) min; P = 0·005) were also affected, with L-L being the slowest. Thirdly, inulin reduced GE lag and latency phases (P < 0·05) compared with NO-S. Lactulose accelerates OCTT but delays GE compared with inulin. Inulin accelerates the onset of stomach emptying, but it has no effect on GE half-time. For these reasons, inulin is the preferred substrate for the H2 breath test.

Gastric emptying flow curves separated from carbon-labeled octanoic acid breath test results

1998 ◽  
Vol 275 (1) ◽  
pp. G169-G175 ◽  
Author(s):  
B. D. Maes ◽  
G. Mys ◽  
B. J. Geypens ◽  
P. Evenepoel ◽  
Y. F. Ghoos ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Test Meal ◽  
Breath Test ◽  
Octanoic Acid ◽  
Lag Phase ◽  
Test Results ◽  
Flow Curves ◽  
Mean Values ◽  
Good Agreement ◽  
Emptying Time

Recently, we developed the [13/14C]octanoic acid breath test to measure gastric emptying of solids. Although the method has been validated extensively, absorption, metabolism, and excretion of the label in the breath need to be corrected for. In this study a mathematical model was developed that allows for 1) separation of the global CO2 excretion after ingestion of the labeled test meal into the emptying rate of the labeled test meal from mouth to pylorus and the postgastric processing of absorption, metabolism, and excretion of the label, and 2) numerical calculation of the half-emptying time and lag phase of the emptied meal. The model was applied to the gastric emptying results obtained by simultaneous scintigraphic and breath test measurements. An excellent correlation was found between the gastric half-emptying time ( r = 0.98) and lag phase ( r = 0.85) determined scintigraphically and via breath test. There was also a good agreement between the two methods [mean values and confidence limits for differences: t ½= 10 min (−20 to 41) and t lag = −3 min (−39 to 34)]. Moreover, the separated gastric emptying curves, lacking the influence of postgastric processing of the label, showed real patterns of gastric outflow, which changes from moment to moment.

Solid phase gastric emptying times in the dog measured by 13C-sodium-acetate breath test and 99mTechnetium radioscintigraphy

2010 ◽  
Vol 38 (04) ◽  
pp. 211-216 ◽  
Author(s):  
K. Failing ◽  
R. Neiger ◽  
S. Schmitz
Keyword(s):  
Gastric Emptying ◽  
Clinical Significance ◽  
Test Meal ◽  
Sodium Acetate ◽  
Breath Test ◽  
Healthy Adult ◽  
Solid Phase ◽  
Non Invasive ◽  
The Mean

Summary Objective: The aim of the study was to assess solid gastric emptying via non-invasive 13C-sodium acetate breath test and compare this technique to 99mTechnetium scintigraphy in 12 healthy adult dogs. Material and methods: The dogs were fed a test meal containing either 100 mg 13C-sodium acetate or 150–250 MBq 99mTechnetium albumin colloid. Breath test and scintigraphy were performed on two consecutive days; this set of procedures was repeated in all dogs. Breath samples and scintigrams were obtained at baseline and every 15 minutes for 4 hours, then every 30 minutes for another 2 hours. 25%, 50% and 75% gastric emptying times for breath test (Gt25%b, Gt50%b, Gt75%b) and scintigraphy (Gt25%s, Gt50%s, Gt75%s) were calculated and compared. Results: The mean (± SD) Gt50%b and Gt50%s were 165 (± 28.1) and 71 (± 16.6) minutes, respectively. There was a significant correlation at all three gastric emptying times between breath test and scintigraphy. Conclusion and clinical significance: While gastric emptying times between both methods varied considerably, both methods correlated significantly showing that the gastric emptying breath test can be used to assess gastric emptying times in dogs.

13C-octanoic acid breath test (OBT) with a new test meal (EXPIROGer®): Toward standardization for testing gastric emptying of solids

2010 ◽  
Vol 42 (8) ◽  
pp. 549-553 ◽  
Author(s):  
Francesco Perri ◽  
Massimo Bellini ◽  
Piero Portincasa ◽  
Andrea Parodi ◽  
Patrizia Bonazzi ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Test Meal ◽  
Breath Test ◽  
Octanoic Acid

Adaptation to high-fat diet accelerates emptying of fat but not carbohydrate test meals in humans

2002 ◽  
Vol 282 (2) ◽  
pp. R366-R371 ◽  
Author(s):  
K. E. Castiglione ◽  
N. W. Read ◽  
S. J. French
Keyword(s):  
Gastric Emptying ◽  
Dietary Intake ◽  
Test Meal ◽  
High Fat Diet ◽  
Lag Phase ◽  
High Fat ◽  
Free Living ◽  
Gastric Emptying Rate ◽  
High Carbohydrate ◽  
Before And After

Previous work has shown that the gastric emptying rate in animals and humans can adapt due to previous dietary intake. The present study investigated whether adaptation in gastric emptying rate due to consumption of a high-fat diet (HFD) is nutrient specific in humans. Gastric emptying of high-fat and high-carbohydrate test meals was measured (using gamma scintigraphy) before and after consumption of an HFD for 14 days in eight free-living male volunteers. Visual analog ratings of appetite were recorded throughout each test. There was no effect of HFD on any parameters of gastric emptying rate (lag phase, half-emptying time, and linear emptying rate) measured for carbohydrate test meals. HFD led to an acceleration of the linear emptying rate of the high-fat test meal (0.36 vs. 0.47%/min; P < 0.05). All meals reduced appetite ratings, but there were no differences between tests. These results support our previous findings of accelerated gastric emptying of high-fat test meals following an HFD and show that these changes appear to be nutrient specific, confirming recent studies in rats.

Impaired gastric emptying of a solid test meal in patients with Parkinson's disease using 13C-sodium octanoate breath test

2005 ◽  
Vol 375 (3) ◽  
pp. 170-173 ◽  
Author(s):  
Oliver Goetze ◽  
Joerg Wieczorek ◽  
Thomas Mueller ◽  
Horst Przuntek ◽  
Wolfgang E. Schmidt ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gastric Emptying ◽  
Test Meal ◽  
Breath Test ◽  
Sodium Octanoate
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