scholarly journals Short-term, daily intake of yogurt containing Bifidobacterium animalis ssp. lactis Bf-6 (LMG 24384) does not affect colonic transit time in women

2013 ◽  
Vol 111 (2) ◽  
pp. 279-286 ◽  
Author(s):  
Daniel J. Merenstein ◽  
Frank D'Amico ◽  
Caren Palese ◽  
Alexander Hahn ◽  
Jessy Sparenborg ◽  
...  
Keyword(s):  
Transit Time ◽  
Control Period ◽  
Colonic Transit ◽  
Colonic Transit Time ◽  
Active Period ◽  
X Rays ◽  
Bifidobacterium Animalis ◽  
The Mean ◽  
The Cross ◽  
And Control

The present study investigated the effect of Bifidobacterium animalis ssp. lactis Bf-6 (LMG 24 384) (Bf-6)-supplemented yogurt on colonic transit time (CTT). A triple-blinded, randomised, placebo-controlled, two-period cross-over trial was conducted with sixty-eight women with a self-reported history of straining during bowel movements or hard or lumpy stools in the past 2 years. As per regulatory requirements for probiotic studies, eligible women were generally healthy and not actively constipated at the time of enrolment. Participants consumed both Bf-6 and placebo yogurts for 14 d each in a randomised order, with a 6-week washout period between the treatments. The primary outcome, CTT, was assessed via Sitz marker X-rays. The average CTT was 42·1 h for the active period and 43·3 h for the control period (mean difference 1·2 h, 95 % CI − 4·9, 7·4). Since the statistical tests for the cross-over study implied that the mean CTT for the active and control periods in period 2 were biased, the standard protocol suggests examining the results of only period 1 as a traditional randomised controlled trial. This showed that the mean CTT was 35·2 h for the active period v. 52·9 h for the control period (P= 0·015). Bootstrapping demonstrated that both the mean and median differences remained significant (P= 0·016 and P= 0·045, respectively). Few adverse events were noted, with no differences among the active and control periods. The paired analysis showed no differences between the active and control periods during the cross-over trial. Further trials should be conducted in populations with underlying problems associated with disordered transit to determine the potential value of probiotic supplementation more accurately.

scholarly journals Efficacy of Polydextrose Supplementation on Colonic Transit Time, Bowel Movements, and Gastrointestinal Symptoms in Adults: A Double-Blind, Randomized, Placebo-Controlled Trial

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 439 ◽  
Author(s):  
Alvin Ibarra ◽  
Tetyana Pelipyagina ◽  
Matthew Rueffer ◽  
Malkanthi Evans ◽  
Arthur Ouwehand
Keyword(s):  
Transit Time ◽  
Lifestyle Modification ◽  
Controlled Trial ◽  
Gastrointestinal Symptoms ◽  
Colonic Transit ◽  
Colonic Transit Time ◽  
X Rays ◽  
Double Blind ◽  
Bowel Movements ◽  
Secondary Outcomes

The addition of fiber is one of the most important dietary means to relieve constipation through lifestyle modification. Polydextrose (PDX) has been reported in several studies to increase fecal bulk, soften stools, and increase the number of defecations. However, there are few studies on the effect of PDX on colonic transit time (CTT). Therefore, the aim of this study was to demonstrate the effect of PDX on CTT and other aspects of gastrointestinal function during two weeks (Day 1 to Day 14), preceded by a 2-week run-in period (Day -14 to Day -1). A total of 192 adults who were diagnosed with functional constipation per Rome III criteria were recruited for the study. Participants were randomized equally into 4 groups (12 g, 8 g, or 4 g of PDX or placebo per day). The primary endpoint was CTT, assessed using radio-opaque markers and abdominal X-rays on Day 0, the baseline; and Day 15, the end of the intervention. Secondary outcomes that were measured using inventories were the patient assessment of constipation symptoms and quality of life, bowel function index, relief of constipation, bowel movement frequency (BMF), stool consistency, degree of straining, and proportion of bowel movements. Ancillary parameters and harms were also evaluated. The recruited population was not sufficiently constipated (e.g., baseline values for CTT and BMF of 42 h and 8.7 BMF/week, respectively). Despite this limitation, our results demonstrated an increased number of bowel movements when supplemented with PDX at a dosage of 12 g per day for 2 weeks. This dosage also consistently improved the secondary outcomes that were measured using inventories at Day 15, compared with the baseline. No serious or significant adverse events were reported during the study.

Functional cine MRI for the assessment of the colonic transit time—a pilot study

2005 ◽  
Vol 1281 ◽  
pp. 1319
Author(s):  
Ch. Kirchhoff ◽  
S. Buhmann ◽  
Ch. Wielage ◽  
K. Hallfeldt ◽  
A. Lienemann ◽  
...  
Keyword(s):  
Pilot Study ◽  
Transit Time ◽  
Colonic Transit ◽  
Colonic Transit Time ◽  
Cine Mri

Semi-automatic detection of Gd-DTPA-saline filled capsules for colonic transit time assessment in MRI

2008 ◽  
Author(s):  
Christian Harrer ◽  
Sonja Kirchhoff ◽  
Andreas Keil ◽  
Chlodwig Kirchhoff ◽  
Thomas Mussack ◽  
...  
Keyword(s):  
Transit Time ◽  
Automatic Detection ◽  
Colonic Transit ◽  
Colonic Transit Time ◽  
Time Assessment

scholarly journals Longer colonic transit time is associated with laxative and drug use, lifestyle factors, and symptoms of constipation

2018 ◽  
Vol 7 (10) ◽  
pp. 205846011880723 ◽  
Author(s):  
Johan Bohlin ◽  
Erik Dahlin ◽  
Julia Dreja ◽  
Bodil Roth ◽  
Olle Ekberg ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Drug Use ◽  
Transit Time ◽  
Gastrointestinal Symptoms ◽  
Coffee Consumption ◽  
Lifestyle Factors ◽  
Colonic Transit ◽  
Stool Frequency ◽  
Colonic Transit Time ◽  
Female Sex

Background Gastrointestinal symptoms and changes in colonic transit time (CTT) are common in the population. Purpose To evaluate consecutive patients who had been examined for CTT, along with completion of a diary about laxative and drug use, lifestyle factors, and gastrointestinal symptoms, to identify possible associations with longer or prolonged CTT. Material and Methods A total of 610 consecutive patients had undergone the radiopaque marker method with an abdominal X-ray for clinical purposes. The patients had completed a diary regarding medical treatment, lifestyle factors, stool habits, and their perceived constipation and abdominal pain during the examination period. The associations between CTT and laxative use, lifestyle factors, stool habits, and symptoms were calculated by logistic regression. Results Women had longer CTT (2.5 [1.6–3.9] vs. 1.7 [1.1–3.0] days, P < 0.001), lower weekly stool frequency (6 [3–10] vs. 8 [5–12], P = 0.001), and perceived more constipation ( P = 0.025) and abdominal pain ( P = 0.001) than men. High coffee consumption ( P = 0.045), bulk-forming ( P = 0.007) and osmotic ( P = 0.001) laxatives, and lower stool frequency, shaped stool, and perceived constipation ( P for trend < 0.001) were associated with longer CTT. In total, 382 patients (63%) were treated with drugs affecting motility. In the 228 patients without drug treatment, longer CTT was associated with female sex and smoking, and lower frequency of symptoms and prolonged CTT were observed compared to patients using drugs. Tea, alcohol, and abdominal pain did not associate with CTT. Conclusions Female sex, coffee, smoking, drug use, infrequent stools, shaped stool, and perception of constipation are associated with longer or prolonged CTT.

Sign in / Sign up

Export Citation Format

Share Document