scholarly journals Specific serum carotenoids are inversely associated with breast cancer risk among Chinese women: a case–control study

2015 ◽  
Vol 115 (1) ◽  
pp. 129-137 ◽  
Author(s):  
Bo Yan ◽  
Min-Shan Lu ◽  
Lian Wang ◽  
Xiong-Fei Mo ◽  
Wei-Ping Luo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Chinese Women ◽  
Menopausal Status ◽  
Premenopausal Women ◽  
Protective Role ◽  
Teaching Hospitals ◽  
Serum Carotenoids

AbstractPrevious epidemiological studies have revealed the anti-cancer effect of dietary circulating carotenoids. However, the protective role of specific individual circulating carotenoids has not been elucidated. The purpose of this study was to examine whether serum carotenoids, includingα-carotene,β-carotene,β-cryptoxanthin, lycopene and lutein/zeaxanthin, could lower the risk for breast cancer among Chinese women. A total of 521 women with breast cancer and age-matched controls (5-year interval) were selected from three teaching hospitals in Guangzhou, China. Concentrations ofα-carotene,β-carotene,β-cryptoxanthin, lycopene and lutein/zeaxanthin were measured using HPLC. Unconditional logistic regression models were used to calculate OR and 95 % CI using quartiles defined in the control subjects. Significant inverse associations were observed between serumα-carotene,β-carotene, lycopene, lutein/zeaxanthin and the risk for breast cancer. The multivariate OR for the highest quartile of serum concentration compared with the lowest quartile were 0·44 (95 % CI 0·30, 0·65) forα-carotene, 0·27 (95 % CI 0·18, 0·40) forβ-carotene, 0·41 (95 % CI 0·28, 0·61) for lycopene and 0·26 (95 % CI 0·17, 0·38) for lutein/zeaxanthin. However, no significant association was found between serumβ-cryptoxanthin and the risk for breast cancer. Stratified analysis by menopausal status and oestrogen receptor (ER)/progesterone receptor (PR) showed that serumα-carotene,β-carotene, lycopene and lutein/zeaxanthin were inversely associated with breast cancer risk among premenopausal women and among all subtypes of ER or PR status. The results suggest a protective role ofα-carotene,β-carotene, lycopene and lutein/zeaxanthin, but notβ-cryptoxanthin, in breast cancer risk.

scholarly journals Genetic Variants in Group-Specific Component (GC) Gene Are Associated with Breast Cancer Risk among Chinese Women

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Fuxing Chen ◽  
Zheng Zhu ◽  
Fränzel J. B. van Duijnhoven ◽  
Meihua Dong ◽  
Yun Qian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Waist Circumference ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Chinese Women ◽  
Menopausal Status ◽  
Cancer Development ◽  
Specific Component ◽  
Group Specific Component ◽  
Gc Gene

The group-specific component (GC) gene, one of the vitamin D pathway genes, seems to play an important role in cancer development. A population-based breast cancer study including 818 cases and 935 controls in a Chinese population was carried out to evaluate the potential associations of four polymorphisms (rs16847024, rs17467825, rs2298850, and rs3755967) in the GC gene with risk of breast cancer. We detected three SNPs with statistically significant effects on breast cancer development after adjusting for age, menopausal status, body mass index (BMI), family history of breast cancer, income, waist circumference, and education (rs17467825: adjusted OR = 0.80, 95% CI = 0.65–0.99; rs2298850: adjusted OR = 0.80, 95% CI = 0.65–0.98; rs3755967: adjusted OR = 0.80, 95% CI = 0.65–0.98). Stratified analysis found that when an individual had a waist circumference <80 cm, rs17467825, rs2298850, and rs3755967 could markedly reduce the risk of breast cancer. Significant interactions between polymorphisms of rs2298850 and rs3755967 and waist circumference were also observed for breast cancer risk. Combined analysis revealed a significant association among the allele numbers of protective effects with decreased breast cancer risk (Ptrend=0.043). These results indicated that, in the GC gene, genetic mutations might be related to breast cancer susceptibility in Chinese women.

scholarly journals Dietary consumption of phytochemicals and breast cancer risk in Mexican women

2009 ◽  
Vol 12 (6) ◽  
pp. 825-831 ◽  
Author(s):  
Luisa Torres-Sanchez ◽  
Marcia Galvan-Portillo ◽  
Mary S Wolff ◽  
Lizbeth Lopez-Carrillo
Keyword(s):  
Breast Cancer ◽  
Menopausal Status ◽  
Reproductive Factors ◽  
Premenopausal Women ◽  
Protective Role ◽  
Mexican Women ◽  
Dietary Consumption ◽  
History Of ◽  
High Dietary Intake

AbstractObjectiveTo perform an evaluation of selected phytochemicals intake and breast cancer (BC) risk in Mexican women.DesignWe conducted hospital-based case–control study.SettingMexico City between 1994 and 1996.SubjectsA total of 141 histologically confirmed BC cases were age-matched (±3 years) to an equal number of hospital controls. The reproductive history of each woman was obtained by direct interview. The dietary consumption of flavonols, flavones, flavan-3-ols, cinnamic acid, lariciresinol, pinoresinol, secoisolariciresinol, matairesinol and coumestrol was obtained by means of a validated FFQ.ResultsAmong postmenopausal women, high dietary intake of flavonols and flavones was associated with a significant reduction of BC risk (high v. low tertile: OR = 0·21, 95 % CI 0·07, 0·60, P for trend = 0·004 and OR = 0·29, 95 % CI 0·10, 0·82, P for trend = 0·025, respectively); consumption of lignans (lariciresinol and pinoresinol) showed a similar effect, but only among premenopausal women (high v. low tertile: OR = 0·32, 95 % CI 0·10, 0·99, P for trend = 0·051 and OR = 0·19, 95 % CI 0·06, 0·62, P for trend = 0·006, respectively).ConclusionsOur results support a protective role of specific dietary phytochemicals in BC risk by menopausal status, independent of other reproductive factors.

Breast cancer risk in women: the protective role of pregnancy

2010 ◽  
Vol 24 (18) ◽  
pp. 35-40 ◽  
Author(s):  
Vassiliki Costarelli ◽  
Nikos Yiannakouris
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Protective Role

Abstract 874: Low plasma coenzyme Q10 levels and breast cancer risk in Chinese women: Influence of menopausal status

2010 ◽  
Author(s):  
Robert V. Cooney ◽  
Qi Dai ◽  
Yu-Tang Gao ◽  
Wong-Ho Chow ◽  
Xiao-Ou Shu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Coenzyme Q10 ◽  
Chinese Women ◽  
Menopausal Status

scholarly journals Patients’ characteristics, Cytochrome P4501A1 genetic polymorphisms and breast cancer risk in Sudanese women

2021 ◽  
Vol 5 ◽  
Author(s):  
Fatima Hamad ◽  
Sulma I. Mohammed ◽  
Abdelrahim O. Mohamed ◽  
Dafalla O. Abuidris Elmustafa
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Small Sample Size ◽  
Menopausal Status ◽  
Premenopausal Women ◽  
Small Sample ◽  
Cancer History ◽  
Polycyclic Aromatic ◽  
History Of

Background: The CYP1A1 catalyses polycyclic aromatic hydrocarbons activation to reactive metabolites, causing deoxyribonucleic acid (DNA) damage and cancer. It is highly polymorphic and displays ethnic differences in various populations.Aim: To evaluate the association of three polymorphic variants in the CYP1A1 gene with breast cancer in Sudanese women.Sett ing: This is a case-control study.Methods: After consenting, the participants completed questionnaires consisting of sociodemographic data, gynaecological status, and breast cancer history. We recorded clinical data, weight, and height for each woman and drew blood for PCR and RFLP analyses for CYP1A1 genotyping.Results: The CYP1A1 M1 and CYP1A1 M3 genotypes and homozygous CYP1A1 M1 (C/C) and CYP1A1 M3 (C/C) genotypes are not associated with breast cancer risk and menopausal status in women. The homozygous CYP1A1 M2 (A/A) genotype had a significant association with a risk reduction of breast cancer in premenopausal women. In contrast, the heterozygous CYP1A1 M2 (A/G) and the homozygous (G/G) are associated with significant breast cancer risk.Conclusion: Despite the limitations encountered in this study that included the small sample size and availability of age-matched controls, the results suggest that the CYP1A1 M2 polymorphism, educational level, and family history of breast cancer may have an association with the risk of developing breast cancer amongst Sudanese women and warrant confirmation in more extensive studies.

Mammographic Density: Intersection of Science, the Law, and Clinical Practice

2013 ◽  
pp. e63-e69
Author(s):  
Scott Hollenbeck ◽  
Patricia Keely ◽  
Victoria Seewaldt
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Mammographic Density ◽  
Menopausal Status ◽  
Increased Risk ◽  
Reduction Strategies ◽  
High Mammographic Density ◽  
Risk Reduction Strategies

High mammographic density is associated with a two- to sixfold increased risk of breast cancer. Mammographic density can be altered by endogenous and exogenous hormonal factors and generally declines with age. Mammographic density is affected by confounding factors such as age, parity, menopausal status, and body mass index (BMI), thus making interpretation of mammographic density challenging. None of the established means of measuring mammographic density are entirely satisfactory because they are time consuming and/or subjective. Although mammographic density has been shown to predict breast cancer risk, the role of mammographic density in precisely assessing a woman's breast cancer risk over her lifetime and evaluating response to risk-reduction strategies cannot be fully realized until we have a better understanding of the biology that links mammographic density to breast cancer risk.

Breast cancer risk in women: the protective role of pregnancy

2010 ◽  
Vol 24 (18) ◽  
pp. 35-40 ◽  
Author(s):  
Vassiliki Costarelli ◽  
Nikos Yiannakouris
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Protective Role

scholarly journals Endogenous hormones and risk of invasive breast cancer in pre- and post-menopausal women: findings from the UK Biobank

2021 ◽  
Author(s):  
Sandar Tin Tin ◽  
Gillian K. Reeves ◽  
Timothy J. Key
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Invasive Breast Cancer ◽  
Cox Regression ◽  
Menopausal Status ◽  
Endogenous Hormones ◽  
Uk Biobank ◽  
Menopausal Women ◽  
Post Menopausal

Abstract Background Some endogenous hormones have been associated with breast cancer risk, but the nature of these relationships is not fully understood. Methods UK Biobank was used. Hormone concentrations were measured in serum collected in 2006–2010, and in a repeat subsample (N ~ 5000) in 2012–13. Incident cancers were identified through data linkage. Cox regression models were used, and hazard ratios (HRs) corrected for regression dilution bias. Results Among 30,565 pre-menopausal and 133,294 post-menopausal women, 527 and 2,997, respectively, were diagnosed with invasive breast cancer during a median follow-up of 7.1 years. Cancer risk was positively associated with testosterone in post-menopausal women (HR per 0.5 nmol/L increment: 1.18; 95% CI: 1.14, 1.23) but not in pre-menopausal women (pheterogeneity = 0.03), and with IGF-1 (insulin-like growth factor-1) (HR per 5 nmol/L increment: 1.18; 1.02, 1.35 (pre-menopausal) and 1.07; 1.01, 1.12 (post-menopausal); pheterogeneity = 0.2), and inversely associated with SHBG (sex hormone-binding globulin) (HR per 30 nmol/L increment: 0.96; 0.79, 1.15 (pre-menopausal) and 0.89; 0.84, 0.94 (post-menopausal); pheterogeneity = 0.4). Oestradiol, assessed only in pre-menopausal women, was not associated with risk, but there were study limitations for this hormone. Conclusions This study confirms associations of testosterone, IGF-1 and SHBG with breast cancer risk, with heterogeneity by menopausal status for testosterone.

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