scholarly journals Multi-micronutrient supplementation during pregnancy for prevention of maternal anaemia and adverse birth outcomes in a high-altitude area: a prospective cohort study in rural Tibet of China

2017 ◽  
Vol 118 (6) ◽  
pp. 431-440 ◽  
Author(s):  
Yijun Kang ◽  
Shaonong Dang ◽  
Lingxia Zeng ◽  
Duolao Wang ◽  
Qiang Li ◽  
...  

AbstractAnaemia during pregnancy, characterised by Hb <110 g/l, is a specific risk factor for adverse maternal and perinatal outcomes in developing countries. The objective of this study was to determine the effectiveness of daily antenatal supplementation with multiple micronutrients (MMN) compared with folic acid (FA) on the occurrence of anaemia among pregnant women and their infants’ health in a high-altitude area. A prospective cohort study was carried out in two rural counties in Tibet from 2007 to 2012. A total of 1149 eligible pregnant women were allocated daily supplementation with FA in one county and MMN containing a recommended allowance of twenty-three vitamins and minerals in another county starting ≤24 weeks of gestation and continuing until delivery. Compared with the FA group, prenatal supplementation with MMN was significantly associated with reduced odds of anaemia in the third trimester. This was demonstrated in the primary outcome, with an adjusted OR (AOR) of 0·63; 95 % CI 0·45, 0·88 and P=0·007 and also reduced odds of preterm delivery (AOR: 0·31; 95 % CI 0·15, 0·61; P=0·001). There was no difference between MMN and FA groups in mean birth weight (adjusted mean difference: 36·78; 95 % CI −19·42, 92·98 g; P=0·200), whereas MMN supplementation significantly reduced the odds of low-birth weight (LBW) babies (AOR: 0·58; 95 % CI 0·36, 0·91; P=0·019). In conclusion, the antenatal MMN supplementation in rural Tibet is associated with a reduction of maternal anaemia in the third trimester, and may potentially decrease the risk of preterm delivery and LBW babies.

2020 ◽  
Author(s):  
Shahrzad Nematollahi ◽  
Mohammad Ali Mansournia ◽  
Abbas Rahimi-Foroushani ◽  
Ali Mouseli ◽  
Hossein Shabkhiz ◽  
...  

Abstract BackgroundTo estimate Population Attributable Fractions (PAFs) and Generalized Impact Fractions (GIFs) for LBW following scenarios to remove or decrease prenatal use of caffeine or water pipe.Methods‎Using data of 861 pregnant women from a population-based prospective cohort study ‎in suburbs of Bandar Abbas city (2016-2018), PAFs and GIFs were calculated based on the relative risk scale. Practical interventional scenarios to reduce the exposure prevalence were developed for calculation of GIFs. ResultsThe cumulative incidence of LBW was 16.1%. An estimated 19% (95%CI: 6, 30%) of LBW neonates was attributed to dietary caffeine intake of >100 mg/day and 11% (95%CI: 8,14%) to water pipe smoking. Action plans to reduce caffeine intake and water pipe smoking suggested an avoidable burden of LBW cases of approximately 10.7% (95% CI: 6.6, 25.3%) and 5.7% ‎‎(95%CI: ‎5.0, 6.8%), respectively.‎ConclusionsWater pipe smoking and excessive consumption of caffeine during pregnancy decreased birth weight. Practical action plans to control water pipe smoking ‎and to prevent excessive intake of ‎caffeine ‎among pregnant women would substantially reduce LBW burden in the south of Iran. ‎


1990 ◽  
Vol 43 (5) ◽  
pp. 461-466 ◽  
Author(s):  
J.A. Knottnerus ◽  
L.R. Delgado ◽  
P.G. Knipschild ◽  
G.G.M. Essed ◽  
F. Smits

2017 ◽  
pp. 66-68
Author(s):  
V.I. Oshovskiy ◽  
◽  
E.G. Solovey ◽  

The article presents the primary results of prospective cohort study of fetal activity in the third trimester of physiological pregnancy. The objective: the establishment of periods of spirits and emotional activity of the fetus in the third trimester of physiological pregnancy. Materials and methods. The study included 300 somatically healthy patients in the period of 28 weeks of pregnancy with a non-obstructed obstetric anamnesis, a single-fetal physiological pregnancy that occurred in the natural cycle, with normal results of the I and II prenatal screenings that were in the Kyiv city hospital No.2 and the medical center «Uniklinika» in 2015–2016. Results. The frequency and strength of the shocks are analyzed depending on the time of the day and the gestational age. The conclusion. It is established that the most emotionally active period of the fetus falls on the evening hours – from 20:00 to 23:00. The maximum frequency of tremors is typical for the period 28-32 weeks of gestation, the maximum force of tremors is observed between the 32-nd and 36-th weeks of pregnancy. Key words: actography, fetal movements, intrauterine homeostasis.


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