Erythrokinetic studies on baboons (Papio anubis) with acute experimental schistosomiasis mansoni

1977 ◽  
Vol 51 (2) ◽  
pp. 95-104 ◽  
Author(s):  
P. H. Holmes ◽  
E. R. James ◽  
J. M. Maclean ◽  
G. S. Nelson ◽  
M. G. Taylor
Keyword(s):  
Blood Loss ◽  
Cell Survival ◽  
Cell Kinetics ◽  
Good Condition ◽  
Red Cell ◽  
Papio Anubis ◽  
Schistosomiasis Mansoni ◽  
Red Cell Survival ◽  
Circulating Volume ◽  
Faecal Blood Loss

ABSTRACTThe erythrokinetics of three baboons were studied over a twelve week period after infection with 3 000 cercariae of S. mansoni and compared with three uninfected control animals. In addition to monitoring changes in haematological and parasitological parameters several radioisotopic techniques were used concurrently to measure alterations in red cell kinetics. In particular 51Cr-labelled red cells and 59Fe-ferric citrate were used to measure red cell production, circulating volume, survival time and routes of loss.All the animals remained in good condition despite heavy infection and the pathophysiological changes were in general mild and transient in nature. The principle alterations were associated with patency and consisted of a modest fall in haematocrit, some inappetence and the appearance of blood-stained mucus in the faeces. Red cell survival was reduced in the infected animals and this was correlated with an increase in faecal blood loss and haemodilution. There was no evidence of haemolytic factors or depressed erythropoiesis having any aetiological role in the anaemia.The results confirmed the complexities of schistosomal anaemia as well as the ability of primates to withstand heavy parasitic burdens for short periods with minimal pathophysiological disturbance.

Automated Differential Agglutination Technic to Measure Red Cell Survival

Transfusion ◽  
1968 ◽  
Vol 8 (2) ◽  
pp. 74-83 ◽  
Author(s):  
I. O. Szymanski ◽  
C. R. Valeri
Keyword(s):  
Cell Survival ◽  
Red Cell ◽  
Red Cell Survival

Erythropoiesis and red cell survival in the hypothyroid dog

1963 ◽  
Vol 204 (3) ◽  
pp. 415-418 ◽  
Author(s):  
Martin J. Cline ◽  
Nathaniel I. Berlin
Keyword(s):  
Cell Survival ◽  
Iron Concentration ◽  
Vitamin B ◽  
Dietary Iron ◽  
Red Cell ◽  
Iron Intake ◽  
Turnover Rates ◽  
Erythrocyte Survival ◽  
Red Cell Survival ◽  
Cell Synthesis

Determinations of blood volume, total red cell volume, plasma and red cell iron turnover rates, and red cell survival were performed in seven dogs prior to and subsequent to radioiodine destruction of the thyroid gland. Anemia developed slowly in all animals as a result of a diminished rate of red cell synthesis. Erythrocyte survival was unaffected by thyroid ablation. Serum iron concentration decreased in five animals despite the apparent adequacy of dietary iron intake and the absence of detectable external loss. In two animals, parenteral administration of iron failed to correct the anemia. Vitamin B12 was ineffective in correcting the anemia or in producing a reticulocyte response in two other animals.

Fibrinogen, Platelet and Red Cell Kinetics in Mice Bearing an Experimental Tumor

1975 ◽  
Author(s):  
A. Poggi ◽  
N. Polentarutti ◽  
M. B. Donati ◽  
G. de Gaetano ◽  
S. Garattini
Keyword(s):  
Cell Kinetics ◽  
Fibrinogen Level ◽  
Low Grade ◽  
Red Cell ◽  
Experimental Tumor ◽  
Tumor Implantation ◽  
The Third ◽  
Red Cell Survival ◽  
Observation Period

In view of the possible role of platelets and coagulation mechanisms in the growth and dissemination of solid tumors, a number of haematological parameters have been followed during development of an experimental syngeneic tumor in mice (Lewis Lung Carcinoma, 3LL). This tumor, when transplanted intramuscularly in C57,B1/6 mice, grows locally and gives spontaneous metastases to the lungs. The transplanted animals survive for about 4 weeks. Metastases are visible since the third week. A slight but constant increase in plasma fibrinogen level and a marked thrombocytopenia were observed starting during the second week after tumor implantation. No other significant changes in coagulation and fibrinolysis parameters were found. Moreover, the animals developed a marked haemolytic anaemia, possibly microangiopathic in origin. 125I-fibrinogen survival was decreased of about 20% during the second week after tumor implantation and was not further reduced later on. Fibrinogen turnover was accelerated since the second week and was further increased thereafter, being more than doubled at the end of the third week. Labelled fibrinogen accumulated in the primary tumor and in the lungs; its rats of disappearance from the tumor was much slower than from lungs or blood. These data suggest the occurrence of a low-grade, localized fibrinogen consumption (intravascular coagulation ?). 51Cr-platelet survival was not modified throughout the observation period, whereas platelet turnover was markedly reduced since the end of the second week, suggesting a defective platelet production. 51Cr-red cell survival was drastically reduced to about 30% of controls starting from the second week, whereas labelled red cell turnover was almost doubled. The pathogenetic relevance of the observed modifications in the processes of grwoth and dissemination of 3 LL remains to be established.(Supported by Grant NIH-PHRB-IRO1 CA 12764–01.

scholarly journals Excess Hemolysis in Subjects with Severe Iron Deficiency Anemia Associated and Nonassociated with Hookworm Infection

Blood ◽  
1965 ◽  
Vol 25 (1) ◽  
pp. 73-91 ◽  
Author(s):  
MIGUEL LAYRISSE ◽  
JESÚS LINARES ◽  
MARCEL ROCHE ◽  
Adelina Ojeda ◽  
Alvaro Carstens ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Cell Survival ◽  
Iron Deficiency Anemia ◽  
Red Cells ◽  
Deficiency Anemia ◽  
Intrinsic Defect ◽  
Red Cell ◽  
Hookworm Infection ◽  
Iron Treatment ◽  
Red Cell Survival

Abstract An excess hemolysis was found in subjects with iron deficiency anemia associated with hookworm infection. Red cell survival, measured with Cr51 and DFP32 in the subjects before deworming, showed a marked disproportion between the decrease of the survival and the amount of daily intestinal blood loss in most cases. Excess of hemolysis was still present after more than 90 per cent of the parasites were removed. Red cell survival became normal after correction of anemia through iron treatment. Excess of hemolysis was also present in noninfected subjects with iron deficiency anemia due to other causes. The reduction in the survival of the erythrocytes from infected subjects transfused into normal recipients shows that the hemolytic process is due to an intrinsic defect of the red cells. The low values of hemoglobinemia and the presence of haptoglobins in the plasma indicate that hemoglobin has not been liberated in excess intravascularly. Finally, the fact that the red cells from an infected patient taken after deworming survived normally in splenectomized recipients indicates that the spleen is probably the principal site of the red cell destruction. The clinical and autopsy findings suggest that splenic function is not pathologically increased, but rather that this organ is acting physiologically at a more rapid rate, "culling" the abnormal circulating red cells and thus leading to a decrease in red cell survival. The studies presented here also indicate that the hookworm infection per se does not induce hemolysis.

Measurement of red cell survival using biotin-labeled red cells: validation against 51Cr-labeled red cells

Transfusion ◽  
1999 ◽  
Vol 39 (2) ◽  
pp. 156-162 ◽  
Author(s):  
Donald M. Mock ◽  
Gary L. Lankford ◽  
John A. Widness ◽  
Leon F. Burmeister ◽  
Daniel Kahn ◽  
...  
Keyword(s):  
Cell Survival ◽  
Red Cells ◽  
Red Cell ◽  
Red Cell Survival

Splenomegaly with Hypersplenism in Sickle Cell Anemia Treated by Radiation—Case Report

PEDIATRICS ◽  
1971 ◽  
Vol 48 (3) ◽  
pp. 457-458
Author(s):  
Annemarie Sommer ◽  
Stella B. Kontras
Keyword(s):  
Cell Survival ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Marked Improvement ◽  
Costal Margin ◽  
Red Cell ◽  
Older Children ◽  
Before And After ◽  
Red Cell Survival ◽  
Survival Studies

The incidence of splenomegaly in sickle cell anemia (defined as a spleen easily palpated below the costal margin in quiet respiration) appears to be around 10% after 10 years of age. Persistent splenomegaly in older children is rare and frequently is associated with hypersplenism. Splenectomy has been the treatment of choice in several reported cases based on red cell survival studies before and after splenectomy.1-3 Removal of the spleen has been found to be associated with marked improvement of previously very shortened red cell survival. We want to report the case of a 12-year-old boy with sickle cell anemia, splenomegaly, and sickle cell heart disease who was treated by radiation therapy for his enlarged spleen because of hypersplenism.

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