scholarly journals Diphtheria-tetanus-pertussis vaccine combined with Bordetella parapertussis vaccine

1962 ◽  
Vol 60 (3) ◽  
pp. 289-293 ◽  
Author(s):  
Neda Köhler-Kubelka
Keyword(s):  
Clinical Examination ◽  
Pertussis Vaccine ◽  
Bordetella Pertussis ◽  
Whooping Cough ◽  
Production Test ◽  
Post Vaccination ◽  
Bordetella Parapertussis ◽  
Cross Reactions ◽  
Combined Vaccine

Investigations carried out to ascertain the ability of various strains of Bordetella pertussis and B. parapertussis to produce agglutinins have shown that the agglutinin response is considerably greater with B. parapertussis.Children inoculated with a combined vaccine in which the parapertussis element contained B. parapertussis in only one-twelfth of the concentration of B. pertussis in the pertussis element showed agglutinins in their sera in titres well above 1:300 for both organisms. There were no cross-reactions and the serological responses were specific throughout. The vaccine used was the standard diphtheria-tetanus-pertussis (DTP) prophylactic to which had been added a vaccine prepared from recently isolated strains of B. parapertussis.Agglutinin titres of both whooping cough components with the combined vaccine were somewhat lower in mice than was the case when monovalent vaccines were used, but they were considered to be satisfactory.It is suggested that the agglutination production test in mice could be used for the assessment of protective power of B. parapertussis vaccines against infection.I wish to thank Dr Ikić, director of the Institute of Immunology, Zagreb, who enabled me to perform all these examinations, further to Dr B. Mravunac and Dr Z. Radanov for having carried out vaccination in children and for the clinical examination of post vaccination reactions.

Bordetella parapertussis outbreak in Bisham, Pakistan in 2009–2010: fallout of the 9/11 syndrome

2015 ◽  
Vol 143 (12) ◽  
pp. 2619-2623 ◽  
Author(s):  
S. JAVED ◽  
F. SAID ◽  
S. A. M. A. S. EQANI ◽  
H. BOKHARI
Keyword(s):  
Health Services ◽  
Bordetella Pertussis ◽  
Whooping Cough ◽  
The Political ◽  
Bordetella Parapertussis ◽  
Routine Identification ◽  
Political Unrest ◽  
Adults And Children ◽  
A Minor ◽  
Culture Positive

SUMMARYPertussis or whooping cough is a highly contagious community disease mainly caused by Bordetella pertussis and B. parapertussis. We report a minor outbreak of whooping cough (2009–2010) in symptomatic subjects from Bisham, near Swat, Khyber Pukhtoonkhawa province, Pakistan. Interestingly, our results show that all the culture-positive isolates (n = 21) collected from children (average age 3·46 years), were identified as B. parapertussis after routine identification tests and PCR IS481, IS1001 and IS1002. Furthermore, in the affected patients, none had received immunization with diphtheria-pertussis-tetanus (DTPw) vaccine. Therefore, the possibility of the re-emergence of the disease due to limitation of basic health services as a result of the political unrest due to the 9/11 situation is also examined. Moreover, we discuss the importance of vaccinating both adults and children with DTPwPaw vaccine containing both organisms for better protection.

Whooping cough in Pakistan: Bordetella pertussis vs Bordetella parapertussis in 2005–2009

2011 ◽  
Vol 43 (10) ◽  
pp. 818-820 ◽  
Author(s):  
Habib Bokhari ◽  
Fahad Said ◽  
Muhammad A. Syed ◽  
Amjad Mughal ◽  
Yasmeen F. Kazi ◽  
...  
Keyword(s):  
Bordetella Pertussis ◽  
Whooping Cough ◽  
Bordetella Parapertussis

New Thoughts on Pertussis

PEDIATRICS ◽  
1979 ◽  
Vol 63 (6) ◽  
pp. 941-942
Author(s):  
Samuel L. Katz ◽  
Catherine M. Wilfert
Keyword(s):  
United States ◽  
Pertussis Vaccine ◽  
Bordetella Pertussis ◽  
Whooping Cough ◽  
Sharp Decrease ◽  
The United States ◽  
Critical Examination ◽  
Immunization Programs

The success of initial pertussis immunization programs resulted not only in a sharp decrease in the incidence of the disease but also in a diminution of interest in and research on the organism, and complacency with regard to the vaccine itself. Concern and apprehension about both the efficacy and the safety of pertussis vaccine have recently stimulated a renewed investigative interest in the biology of Bordetella pertussis. This occurs at a time. when cases of pertussis reported in the United States are at an all-time low (less than 2,000 in 1978 contrasted with more than 150,000 in 1950). This infrequency of clinical whooping cough contributes to our desire for a more critical examination of the rare serious complications attributed to the immunizing procedure.

scholarly journals The O Antigen Enables Bordetella parapertussis To Avoid Bordetella pertussis-Induced Immunity

2007 ◽  
Vol 75 (10) ◽  
pp. 4972-4979 ◽  
Author(s):  
Daniel N. Wolfe ◽  
Elizabeth M. Goebel ◽  
Ottar N. Bjornstad ◽  
Olivier Restif ◽  
Eric T. Harvill
Keyword(s):  
Bordetella Pertussis ◽  
Whooping Cough ◽  
Human Populations ◽  
Relative Role ◽  
Human Pathogens ◽  
Bordetella Parapertussis ◽  
Bacterial Surface ◽  
O Antigen ◽  
Causative Agents ◽  
Induced Immunity

ABSTRACT Bordetella pertussis and Bordetella parapertussis are closely related endemic human pathogens which cause whooping cough, a disease that is reemerging in human populations. Despite how closely related these pathogens are, their coexistence and the limited efficacy of B. pertussis vaccines against B. parapertussis suggest a lack of cross-protective immunity between the two. We sought to address the ability of infection-induced immunity against one of these pathogens to protect against subsequent infection by the other using a mouse model of infection. Immunity induced by B. parapertussis infection protected against subsequent infections by either species. However, immunity induced by B. pertussis infection prevented subsequent B. pertussis infections but did not protect against B. parapertussis infections. The O antigen of B. parapertussis inhibited binding of antibodies to the bacterial surface and was required for B. parapertussis to colonize mice convalescent from B. pertussis infection. Thus, the O antigen of B. parapertussis confers asymmetrical cross-immunity between the causative agents of whooping cough. We propose that these findings warrant investigation of the relative role of B. parapertussis in the resurgence of whooping cough.

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