Malignant parotid salivary gland peripheral nerve sheath tumour in a twelve-year-old girl

1992 ◽  
Vol 106 (8) ◽  
pp. 748-750 ◽  
Author(s):  
Anna C. Athow ◽  
Nigel Kirkham
Keyword(s):  
Salivary Gland ◽  
Spindle Cell ◽  
Positive Staining ◽  
Nerve Sheath Tumour ◽  
Ultrastructural Evidence ◽  
Nerve Sheath ◽  
Parotid Salivary Gland ◽  
Response To Chemotherapy ◽  
S 100 ◽  
Immunohistochemical Studies

AbstractA case of a malignant parotid salivary gland nerve sheath tumour is reported in a 12-year-old girl who developed a right parotid mass. Initial incisional biopsy showed a tumour with a mesenchymal spindle cell appearance. Immunohistochemical studies showed positive staining of tumour cells for vimentin and focally for S-100 protein. These features together with ultrastructural evidence of basal lamina material suggested that the tumour was of nerve sheath origin. After subtotal parotidectomy the tumour metastasised to cervical lymph node and lung. There was evidence of a partial response to chemotherapy. A detailed illustrated histopathological description of the tumour is given.

Recurrence of acoustic neurilemoma as a malignant spindle-cell neoplasm

1990 ◽  
Vol 73 (6) ◽  
pp. 946-950 ◽  
Author(s):  
Catriona A. McLean ◽  
John D. Laidlaw ◽  
David S. B. Brownbill ◽  
Michael F. Gonzales
Keyword(s):  
Cerebellopontine Angle ◽  
Spindle Cell ◽  
Positive Staining ◽  
Nerve Sheath Tumor ◽  
Content Type ◽  
Spindle Cell Neoplasm ◽  
Nerve Sheath ◽  
Cell Neoplasm ◽  
Acoustic Nerve ◽  
S 100

✓ A 75-year-old man presented with a right cerebellopontine angle tumor 11 months after complete macroscopic resection of a right acoustic neurilemoma. Histological examination of the recurrent tumor showed a malignant spindle-cell neoplasm with positive staining for S-100 protein. The patient had no stigmata of von Recklinghausen's disease. It is proposed that this recurrence represents progression from a benign to a malignant acoustic nerve-sheath tumor, an event that is extremely rare outside the clinicopathological context of neurofibromatosis.

Cutaneous Malignant Peripheral Nerve Sheath Tumour (Mpnst) of the Hand: A Review of Current Literature

1993 ◽  
Vol 18 (4) ◽  
pp. 478-481 ◽  
Author(s):  
M. S. E. COADY ◽  
S. POLACARZ ◽  
R. E. PAGE
Keyword(s):  
Peripheral Nerve ◽  
Upper Limb ◽  
Soft Tissues ◽  
Spindle Cell ◽  
Current Knowledge ◽  
Nerve Sheath Tumour ◽  
Nerve Sheath ◽  
Tumour Extension ◽  
Therapeutic Problem ◽  
Peripheral Nerve Sheath Tumour

Malignant peripheral nerve sheath tumours (MPNST) are spindle cell sarcomas normally situated in the deep soft tissues. Cutaneous MPNST is an uncommon variant, usually occurring in the head and neck. When it arises in the upper limb this tumour may pose a considerable diagnostic and therapeutic problem. We present a case of cutaneous MPNST arising in the hand. Tumour extension was exclusively perineural along three major nerve trunks from an interdigital origin. Current knowledge of the clinical behaviour of cutaneous MPNST is reviewed.

Metastatic melanoma presenting as a malignant peripheral nerve sheath tumour

2021 ◽  
Vol 5 (1) ◽  
pp. 1-4
Author(s):  
David John Mackay Smith
Keyword(s):  
Peripheral Nerve ◽  
Metastatic Melanoma ◽  
Spindle Cell ◽  
Correct Diagnosis ◽  
Primary Cutaneous Melanoma ◽  
Tissue Mass ◽  
Nerve Sheath Tumour ◽  
Nerve Sheath ◽  
Spindle Cell Proliferation ◽  
Peripheral Nerve Sheath Tumour

This is a report of a metastatic melanoma presenting clinically as a soft tissue mass and histologically being diagnosed as a malignant peripheral nerve sheath tumour. In this case the metastatic melanoma was preceded by a primary cutaneous melanoma in a similar anatomical region. Histologically the tumour was characterised by a malignant-appearing Spindle cell proliferation, arranged in fascicules. There was no evidence of connection to a nerve, co-existent neurofibroma or stigmata of neurofibromatosis. This presentation is only infrequently mentioned in the literature and heterogeneity can make clinical and histological diagnosis of metastatic melanoma problematic. It can easily be misinterpreted without effective clinico-histological correlation, making a good working relationship between Clinician and Histopathologist essential for correct diagnosis.

scholarly journals Spindle cell sarcomas, suggestive of peripheral nerve sheath tumours, arising in the tongues of two cats

2019 ◽  
Vol 5 (2) ◽  
pp. 205511691987525
Author(s):  
Melanie J Dobromylskyj ◽  
Fernando Martinez ◽  
Anna Lovell
Keyword(s):  
Peripheral Nerve ◽  
Immunohistochemical Staining ◽  
Spindle Cell ◽  
Nerve Sheath Tumour ◽  
Histological Features ◽  
Case Summary ◽  
Nerve Sheath ◽  
Histological Malignancy ◽  
Tip Of The Tongue ◽  
Peripheral Nerve Sheath Tumour

Case summary Two domestic shorthair cats, one an 11-year-old female neutered cat and the other a 13-year-old male neutered cat, presented with partly raised, well-demarcated masses at the rostral tip of the tongue. Histological examination and immunohistochemical staining were consistent with sarcomas, and were most suggestive of peripheral nerve sheath tumours. One tumour had histological features consistent with a malignant peripheral nerve sheath tumour (PNST). Relevance and novel information Feline PNSTs arising on the tongue are rarely described in the published literature, and, to our knowledge, a case of malignant PNST originating at this site has not been described to date. Therefore, this represents a new differential diagnosis for cats presenting with a lingual mass. Regardless of histological malignancy, in cats these tumours have the potential for local recurrence but appear very unlikely to metastasise.

scholarly journals The Diagnostic and Clinical Significance of TFE3 Immunohistochemical Nuclear Expression in Solitary Fibrous Tumour

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Luting Zhou ◽  
Anran Wang ◽  
Guoli Yu ◽  
Jun Zhou ◽  
Haimin Xu ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Synovial Sarcoma ◽  
Clinical Significance ◽  
Spindle Cell ◽  
Dermatofibrosarcoma Protuberans ◽  
Dedifferentiated Liposarcoma ◽  
Spindle Cell Lipoma ◽  
Nerve Sheath Tumour ◽  
Nerve Sheath ◽  
Peripheral Nerve Sheath Tumour

The expression of TFE3 (transcription factor E3) in solitary fibrous tumours (SFTs) and their histologic mimickers was investigated, and the diagnostic value and clinical significance of TFE3 nuclear expression in SFTs were explored. Immunohistochemical analysis for TFE3 was performed on 50 cases of SFTs that were surgically resected. The controls were sample tissues from malignant peripheral nerve sheath tumour, synovial sarcoma, dedifferentiated liposarcoma, spindle cell lipoma, and dermatofibrosarcoma protuberans. The survival of patients with TFE3-positive and TFE3-negative expressions was assessed through the Kaplan-Meier analysis. In 44 of 50 (88%) SFTs, nuclear immunoreactivity for TFE3 was detected. The TFE3 expression was negative in all samples of synovial sarcoma, malignant peripheral nerve sheath tumour, dermatofibrosarcoma protuberans, and spindle cell lipoma and weakly positive in 2 of 10 cases of dedifferentiated liposarcoma. Fluorescence in situ hybridization (FISH) confirmed that the expression of the TFE3 protein is not caused by gene translocation. There was no statistical significance between the association of the TFE3 expression and SFT patient prognosis. Therefore, TFE3 is capable of enhancing the differential diagnosis of SFTs and their histologic mimickers and can be potentially used as a diagnostic marker. The findings also offer valuable insights into SFT diagnosis, aetiology, and associated molecular mechanisms.

scholarly journals Malignant peripheral nerve sheath tumour in a dog presenting as a pseudo aneurysm of the left jugular vein: a case report

2008 ◽  
Vol 53 (No. 12) ◽  
pp. 685-689
Author(s):  
M. Kostov ◽  
Z. Mijovic ◽  
M. Visnjic ◽  
D. Mihailovic ◽  
M. Stojanovic ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Jugular Vein ◽  
Left Kidney ◽  
Signs And Symptoms ◽  
Tumour Mass ◽  
Nerve Sheath Tumour ◽  
Nerve Sheath ◽  
S 100 ◽  
Pseudo Aneurysm ◽  
Peripheral Nerve Sheath Tumour

The authors report an autopsy case of a malignant peripheral nerve sheath tumour in a 9-year-old female Akito-ino dog, presenting as a pseudo aneurysm of the left jugular vein. Signs and symptoms included swelling of the neck and legs, dyspnea, malaise and weight loss. Post-mortem examination revealed a tumour mass (8 × 6, 5 × 6 cm), localized to the left paravertebrally, and on the level of C7 to T2 vertebral bodies; additional masses were observed in both lungs, heart and left kidney. On the basis of necropsy, histological findings and immunophenotype, the tumour was classsified as a malignant peripheral nerve sheath tumour. Immunohistochemistry especially positivity for S-100 protein can be helpful in distinguishing this type of neoplasm from other malignancies with similar morphologies.

An Eyelid Sialoblastoma-Like Tumor with a Sarcomatoid Myoepithelial Component

2007 ◽  
Vol 10 (4) ◽  
pp. 309-314 ◽  
Author(s):  
Tanuja Shet ◽  
Mukta Ramadwar ◽  
Suash Sharma ◽  
Siddhartha Laskar ◽  
Brijesh Arora ◽  
...  
Keyword(s):  
Spindle Cell ◽  
Residual Disease ◽  
Rare Tumor ◽  
Doxorubicin Hydrochloride ◽  
Disease Awareness ◽  
Ultrastructural Evidence ◽  
S 100 ◽  
Myoepithelial Differentiation ◽  
Outer Aspect ◽  
Left Eyelid

Nonround cell tumors are rare in children and often difficult to diagnose. This article describes an 18-month-old child who presented with a mass on the outer aspect of the left eyelid. This mass was incompletely excised. Histologically, the tumor had nests of basaloid and relatively round cells with immature acinar or ductular structures similar to those seen in a conventional sialoblastoma, but these nests were embedded in a malignant spindle cell stroma. This stroma on immunohistochemistry was marked with S-100 and cytokeratin, which, in combination with the pertinent ultrastructural evidence, indicated a myoepithelial differentiation. Overall histologic features suggested a tumor similar to a sialoblastoma with sarcomatoid transformation of the myoepithelial component, hitherto not described in literature. This tumor probably arose from the palpebral lobe of the lacrimal gland. Postsurgery, the patient received chemotherapy (6 cycles of ifosfamide, vincristine, and doxorubicin hydrochloride [Adriamycin]) and local radiotherapy in view of residual disease. Three months after completion of the treatment (1 year after surgery), the patient is well, without any local disease. Awareness of this unusual histology of sialoblastoma will help in avoiding misdiagnosis and also refine treatment-related issues on this rare tumor.

Malignant tumours as a rare cause of recurrent thrombophlebitis of the great saphenous vein

Phlebologie ◽  
2008 ◽  
Vol 37 (06) ◽  
pp. 297-300
Author(s):  
N. König ◽  
H. J. Stark ◽  
P.-M. Baier
Keyword(s):  
Differential Diagnosis ◽  
Saphenous Vein ◽  
Great Saphenous Vein ◽  
Case Reports ◽  
Malignant Tumours ◽  
Nerve Sheath Tumour ◽  
Below The Knee ◽  
Nerve Sheath ◽  
Unfavourable Prognosis ◽  
Peripheral Nerve Sheath Tumour

SummaryWe present two case reports concerning patients who had to undergone surgical treatment according tp the diagnosis of thrombophlebitis with insufficiency of the greater saphenous vein and putative encapsulated haematoma in the lower left leg area. During the operation we found tumours with urgent suspicion of malignancy. The histological examination revealed the diagnosis of mesenchymal chondrosarcoma and malignant peripheral nerve sheath tumour which are extremely malignant, but very rare neoplasmas with unfavourable prognosis. Conclusion: Since both types of tumours are often located below the knee, phlebotomists and vascular surgeons should take them into account as differential diagnosis.

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