Malignant oncocytoma of the parotid gland: a case report with an immunohistochemical and ultrastructural study

1993 ◽  
Vol 107 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Takuya Sugimoto ◽  
Shigeki Wakizono ◽  
Takuya Uemura ◽  
Masazumi Tsuneyoshi ◽  
Munetomo Enjoji
Keyword(s):  
Lymph Nodes ◽  
Rare Case ◽  
Secretory Granules ◽  
Secretory Component ◽  
Tumour Cells ◽  
Parotid Region ◽  
Epithelial Origin ◽  
Acute Pneumonia ◽  
S 100 ◽  
First Admission

AbstractA rare case of a 71 -year-old man with malignant oncocytoma is presented. The tumour was found in the left parotid region with enlarged lymph nodes in the neck. The resected parotid mass consisted of three discrete nodules, each histologically characterized by a uniform proliferation of oncocytic tumour cells. The patient underwent repeated operations for recurrences and metastases, and eventually died of acute pneumonia 18 months after the first admission. Metastases to the lymph nodes, ribs, spine and liver had been clinically pointed out. Immunohistochemically, the tumour cells were positive for a-1-antitrypsin, a-1-antichymotrypsin, lactoferrin, secretory component and carcinoembryonic antigen (CEA), while they were negative for S-100 protein and HHF35 (muscle specific actin). Ultrastructural pictures disclosed numerous mitochondria in the cytoplasm of the tumour cells, revealing neither myofibrils nor secretory granules. These findings therefore support the concept that this tumour is of a glandular epithelial origin.

scholarly journals A Rare Case of Sensory Neuropathy Associated with Transitional Cell Carcinoma of the Bladder

2020 ◽  
Vol 13 (3) ◽  
pp. 1397-1401
Author(s):  
Sujitha Ketineni ◽  
Sreenath Kodali ◽  
Sasikanth Gorantla
Keyword(s):  
Lymph Nodes ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Rare Case ◽  
Transitional Cell ◽  
Sensory Neuropathy ◽  
Endobronchial Ultrasound ◽  
Whole Body ◽  
Initial Symptoms ◽  
Carcinoma Of The Bladder

Malignancies can trigger an autoimmune response against the nervous system and manifest as paraneoplastic neurological syndromes (PNS). Initial symptoms of PNS may develop up to 5 years prior to the diagnosis of the underlying malignancy. We report a rare case of PNS associated with transitional cell carcinoma of the bladder in a 70-year-old male with a 6-month history of rapidly progressive symmetric sensory neuropathy. Peripheral neuropathy serological workup was unremarkable. A paraneoplastic neuropathy panel revealed anti-Hu autoantibodies. Further evaluation with a whole-body PET scan could not identify the primary malignancy, but it showed hypermetabolic hilar lymph nodes. An endobronchial ultrasound biopsy of the hilar lymph nodes was negative for cancer. The patient developed painless hematuria 2.5 years after the onset of the sensory neuropathy. Cystoscopy with biopsy revealed non-muscle-invasive transitional cell carcinoma of the bladder. Progression of the sensory neuropathy stopped after tumor resection. This case highlights the importance of a diligent and systematic approach to diagnose PNS. A relentless search is often required to detect PNS-associated occult malignancies.

Prognostic value of S-100 immunostaining in tumour cells of non-small cell lung cancer

Biomarkers ◽  
2006 ◽  
Vol 11 (3) ◽  
pp. 262-269 ◽  
Author(s):  
E. Jassem ◽  
K. Serkies ◽  
R. Dziadziuszko ◽  
A. Drozdowska ◽  
G. Kobierska-Gulida ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Prognostic Value ◽  
Small Cell ◽  
Tumour Cells ◽  
Small Cell Lung ◽  
S 100

Distribution of S-100 positive dendritic cells in bovine pharynx, tonsils, and retropharyngeal lymph nodes

2008 ◽  
Vol 2 (1) ◽  
pp. 115-120
Author(s):  
Jiaxin Wang ◽  
Haixia Bian ◽  
Wei Shi ◽  
Zhanjun Lu
Keyword(s):  
Dendritic Cells ◽  
Lymph Nodes ◽  
S 100

scholarly journals A rare case of plexiform schwannoma of the lower lip: Treatment and management

2015 ◽  
Vol 48 (02) ◽  
pp. 208-211 ◽  
Author(s):  
Subha Dhua
Keyword(s):  
Immunohistochemical Staining ◽  
Rare Case ◽  
Protein A ◽  
Complete Recovery ◽  
Cystic Degeneration ◽  
Lower Lip ◽  
Plexiform Schwannoma ◽  
S 100 ◽  
Mitotic Figures ◽  
Immunohistochemical Studies

ABSTRACTAn 18-year-old female presented with a swelling on the lower lip, which was insidious in onset and gradually progressive. The mass was completely excised under local anaesthesia. Complete histopathologic and immunohistochemical studies were conducted. The Antoni A areas were found along with typical verocay bodies composed of palisading nuclei and surrounding spaces filled with eosinophilic filaments. No necrosis was noted and there were no atypical mitotic figures. In the Antoni B region, a closely textured matrix with areas of edema, myxomatous changes, cystic degeneration and dilated vessels were noted. On the basis of the histopathologic and immunohistochemical staining with S-100 protein, a diagnosis of plexiform schwannoma was made and has been reported in this study. The post-operative view confirmed complete recovery after 6 weeks of surgery. This is a rare case with the tumour located in the lower lip, as very few cases have been reported in literature and it may be the first one reported from India.

Prognostic Value of Occult Isolated Tumour Cells within Regional Lymph Nodes of Dogs with Malignant Mammary Tumours

2018 ◽  
Vol 158 ◽  
pp. 32-38 ◽  
Author(s):  
A.F. Coleto ◽  
T.M. Wilson ◽  
N.P. Soares ◽  
L.F. Gundim ◽  
I.P. Castro ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Prognostic Value ◽  
Tumour Cells ◽  
Regional Lymph Nodes ◽  
Mammary Tumours ◽  
Isolated Tumour Cells

scholarly journals A Rare Case of Interdigitating Dendritic Cell Sarcoma in the Nasal Cavity

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Eun Jung Lee ◽  
Dong Woo Hyun ◽  
Hyung-Ju Cho ◽  
Jeung-Gweon Lee
Keyword(s):  
Dendritic Cell ◽  
Nasal Cavity ◽  
Rare Case ◽  
Sinus Surgery ◽  
Lymphoid Tissues ◽  
Histologic Study ◽  
Cell Sarcoma ◽  
Dendritic Cell Sarcoma ◽  
Interdigitating Dendritic Cell Sarcoma ◽  
S 100

Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare neoplasm that mainly arises from the lymphoid tissues of the immune system. Although this neoplasm typically occurs anywhere along the lymph nodes, it can also be found at extranodal sites, especially in the head and neck. We experienced a rare case of extranodal IDCS in the nasal cavity, a location that has not been previously reported. A 73-year-old woman presented with a polyp-like mass in the nasal cavity and underwent endoscopic sinus surgery. A histologic study confirmed the mass as IDCS by immunohistochemistry with S-100 antibody, and postoperative adjuvant radiotherapy was administered. Although the incidence is extremely rare, this case suggests that extranodal IDCS should be considered in the differential diagnosis of nasal cavity masses.

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