A rare case of angiodysplasia: penetration of inguinal lymph nodes by large superficial leg veins

Summary Aim: Multiple procedures for the quantification of activity leakage in radiation synovectomy of the knee joint have been described in the literature. We compared these procedures considering the real conditions of dispersion and absorption using a corpse phantom. Methods: We simulated different distributions of the activity in the knee joint and a different extra-articular spread into the inguinal lymph nodes. The activity was measured with a gammacamera. Activity leakage was calculated by measuring the retention in the knee joint only using an anterior view, using the geometric mean of anterior and posterior views, or using the sum of anterior and posterior views. The same procedures were used to quantify the activity leakage by measuring the activity spread into the inguinal lymph nodes. In addition, the influence of scattered rays was evaluated. Results: For several procedures we found an excellent association with the real activity leakage, shown by an r² between 0.97 and 0.98. When the real value of the leakage is needed, e. g. in dosimetric studies, simultaneously measuring of knee activity and activity in the inguinal lymph nodes in anterior and posterior views and calculation of the geometric mean with exclusion of the scatter rays was found to be the procedure of choice. Conclusion: When measuring of activity leakage is used for dosimetric calculations, the above-described procedure should be used. When the real value of the leakage is not necessary, e. g. for comparing different therapeutic modalities, several of the procedures can be considered as being equivalent.

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A rare case of synchronous chronic lymphocytic leukemia/small cell lymphocytic lymphoma and metastatic clear cell variant of cutaneous squamos cell carcinoma in cervical lymph nodes

10.26226/morressier.5b4709856f4cb30010951934 ◽

2018 ◽

Author(s):

Patricia-Irina Stinga ◽

Alexandra Ioana Dragusin

Keyword(s):

Chronic Lymphocytic Leukemia ◽

Lymph Nodes ◽

Cell Carcinoma ◽

Rare Case ◽

Clear Cell ◽

Small Cell ◽

Lymphocytic Leukemia ◽

Cervical Lymph Nodes ◽

Cell Variant ◽

Clear Cell Variant

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A proposed Clino-radio-pathological Risk Scoring System (CRiSS) for prediction and management of inguinal lymph-nodes metastasis in squamous cell carcinoma of the penis

Surgical Oncology ◽

10.1016/j.suronc.2020.12.010 ◽

2021 ◽

Vol 36 ◽

pp. 147-152

Author(s):

Keval N. Patel ◽

Chirag Bhirud ◽

J. Dipin ◽

Kunal Nandy ◽

Vivek Venugopal ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Nodes ◽

Cell Carcinoma ◽

Squamous Cell ◽

Scoring System ◽

Inguinal Lymph Nodes ◽

Lymph Nodes Metastasis ◽

Risk Scoring ◽

Risk Scoring System

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A Rare Case of Sensory Neuropathy Associated with Transitional Cell Carcinoma of the Bladder

Case Reports in Oncology ◽

10.1159/000510742 ◽

2020 ◽

Vol 13 (3) ◽

pp. 1397-1401

Author(s):

Sujitha Ketineni ◽

Sreenath Kodali ◽

Sasikanth Gorantla

Keyword(s):

Lymph Nodes ◽

Transitional Cell Carcinoma ◽

Cell Carcinoma ◽

Rare Case ◽

Transitional Cell ◽

Sensory Neuropathy ◽

Endobronchial Ultrasound ◽

Whole Body ◽

Initial Symptoms ◽

Carcinoma Of The Bladder

Malignancies can trigger an autoimmune response against the nervous system and manifest as paraneoplastic neurological syndromes (PNS). Initial symptoms of PNS may develop up to 5 years prior to the diagnosis of the underlying malignancy. We report a rare case of PNS associated with transitional cell carcinoma of the bladder in a 70-year-old male with a 6-month history of rapidly progressive symmetric sensory neuropathy. Peripheral neuropathy serological workup was unremarkable. A paraneoplastic neuropathy panel revealed anti-Hu autoantibodies. Further evaluation with a whole-body PET scan could not identify the primary malignancy, but it showed hypermetabolic hilar lymph nodes. An endobronchial ultrasound biopsy of the hilar lymph nodes was negative for cancer. The patient developed painless hematuria 2.5 years after the onset of the sensory neuropathy. Cystoscopy with biopsy revealed non-muscle-invasive transitional cell carcinoma of the bladder. Progression of the sensory neuropathy stopped after tumor resection. This case highlights the importance of a diligent and systematic approach to diagnose PNS. A relentless search is often required to detect PNS-associated occult malignancies.

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Prognostic Factors in Patients With Melanoma Metastatic to Axillary or Inguinal Lymph Nodes

Annals of Surgery ◽

10.1097/00000658-199111000-00014 ◽

1991 ◽

Vol 214 (5) ◽

pp. 627-636 ◽

Cited By ~ 124

Author(s):

DANIEL G. COIT ◽

ANDRE ROGATKO ◽

MURRAY F. BRENNAN

Keyword(s):

Prognostic Factors ◽

Lymph Nodes ◽

Inguinal Lymph Nodes

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Subcutaneous sacrococcygeal ependymoma with inguinal lymph node metastastis

Journal of Neurosurgery ◽

10.3171/jns.1988.68.3.0474 ◽

1988 ◽

Vol 68 (3) ◽

pp. 474-477 ◽

Cited By ~ 23

Author(s):

G. W. P. M. Kramer ◽

E. Rutten ◽

J. Sloof

Keyword(s):

Lymph Node ◽

Lymph Nodes ◽

Inguinal Lymph Node ◽

Content Type ◽

Inguinal Lymph Nodes ◽

Fine Print

✓ A patient with a subcutaneous sacrococcygeal ependymoma and metastasis to the inguinal lymph nodes is presented and his treatment is described. Previous reports on sacrococcygeal ependymoma are reviewed.

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Mesenchymal stem cells induce the expansion of regulatory T cells in abortion-prone mice

Reproduction ◽

10.1530/rep-20-0320 ◽

2021 ◽

Author(s):

Amir Salek Farrokhi ◽

Amir-Hassan Zarnani ◽

Fatemeh Rezaei kahmini ◽

Seyed Mohammad Moazzeni

Keyword(s):

Stem Cells ◽

T Cells ◽

Mesenchymal Stem Cells ◽

Regulatory T Cells ◽

Immune Responses ◽

Lymph Nodes ◽

De Novo ◽

Abortion Rate ◽

Cellular Mechanisms ◽

Inguinal Lymph Nodes

Recurrent pregnancy loss (RPL) is one of the most common complications of early pregnancy associated in most cases with local or systemic immune abnormalities such as the diminished proportion of regulatory T cells (Tregs). Mesenchymal stem cells (MSCs) have been shown to modulate immune responses by de novo induction and expansion of Tregs. In this study, we analyzed the molecular and cellular mechanisms involved in Treg-associated pregnancy protection following MSCs administration in an abortion-prone mouse mating. In a case-control study, syngeneic abdominal fat-derived MSCs were administered intraperitoneally (i.p) to the DBA/2-mated CBA/J female mice on day 4.5 of pregnancy. Abortion rate, Tregs proportion in spleen and inguinal lymph nodes, and Ho1, Foxp3, Pd1, and Ctla4 genes expression at the feto-maternal interface were then measured on day 13.5 of pregnancy using flow cytometry and quantitative RT- PCR, respectively. The abortion rate in MSCs-treated mice was significantly reduced and normalized to the level observed in normal pregnant animals. We demonstrated a significant induction of Tregs in inguinal lymph nodes but not in the spleen following MSCs administration. Administration of MSCs remarkably upregulated the expression of HO1, Foxp3, Pd1, and Ctla4 genes in both placenta and decidua. Here, we show that MSCs therapy could protect the fetus in the abortion-prone mice through Tregs expansion and up-regulation of Treg-related genes. These events could establish an immune-privileged microenvironment, which participates in regulation of detrimental maternal immune responses against the semi-allogeneic fetus.

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