Genetic and clinical aspects of wood dust related intestinal-type sinonasal adenocarcinoma: a review

AbstractA sporadic case of the intestinal-type sinonasal adenocarcinoma is described. The patient was a comparatively young 33-year-old woman employed as a senior biochemical scientific technologist for several years. The light microscopical pattern was that of a papillary-tubular adenocarcinoma with areas of more solid mucinous elements in the deeper parts of the neoplasm. The neoplasm had invaded the nasal septum and reached the left orbit invading the left ethmoidal sinus. The glands were lined by columnar cells with elongated spindle-shaped nuclei and the cells expressed cytokeratin, carcinoembryonic antigen (CEA), Chromogranin A, gastrin and serotonin but not neurone-specific enolase (NSE) nor synaptophysin. Neurosecretory granules were present. There was no history of wood dust inhalation and her exposure to chemicals is of some interest but had probably little or no role in the causation of this neoplasm.

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Benign Lesions in Mucosa Adjacent to Intestinal-Type Sinonasal Adenocarcinoma

Pathology Research International ◽

10.4061/2011/230147 ◽

2011 ◽

Vol 2011 ◽

pp. 1-8 ◽

Cited By ~ 4

Author(s):

Blanca Vivanco ◽

José Luis Llorente ◽

Jhudit Perez-Escuredo ◽

César Álvarez Marcos ◽

Manuel Florentino Fresno ◽

...

Keyword(s):

P53 Protein ◽

Squamous Metaplasia ◽

Subsequent Development ◽

Intestinal Type ◽

Wood Dust ◽

Precursor Lesions ◽

Benign Lesions ◽

Histological Changes ◽

Adjacent Mucosa ◽

Sinonasal Adenocarcinoma

Occupational exposure to wood dust is a strong risk factor for the development of intestinal-type sinonasal adenocarcinoma (ITAC); however, knowledge on possible precursor lesions or biomarkers is limited. Fifty-one samples of tumor-adjacent mucosa and 19 control samples of mucosa from the unaffected fossa of ITAC patients were evaluated for histological changes and p53 protein expression. Mild dysplasia was observed in 14%, cuboidal metaplasia in 57%, intestinal metaplasia in 8%, squamous metaplasia in 24%, and cylindrocellular hyperplasia in 53% of cases. P53 immunopositivity was generally weak occurring most frequently in squamous metaplasia. Wood dust etiology did not appear of influence on the histological changes, but p53 showed a tendency for higher positivity. Dysplasia adjacent to tumor was indicative of subsequent development of recurrence. In conclusion, precursor lesions do occur in mucosa adjacent to ITAC. This is clinically important, because it may justify the screening of high-risk individuals such as woodworkers.

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Occurrence of Sinonasal Intestinal-Type Adenocarcinoma and Non-Intestinal-Type Adenocarcinoma in Two Countries with Different Patterns of Wood Dust Exposure

Cancers ◽

10.3390/cancers13205245 ◽

2021 ◽

Vol 13 (20) ◽

pp. 5245

Author(s):

Ilmo Leivo ◽

Reetta Holmila ◽

Danièle Luce ◽

Torben Steiniche ◽

Michael Dictor ◽

...

Keyword(s):

Systematic Study ◽

Diagnostic Workup ◽

Intestinal Type ◽

Dust Exposure ◽

Wood Dust ◽

Systematic Comparison ◽

Sinonasal Adenocarcinoma ◽

Intestinal Type Adenocarcinoma ◽

Tumor Types

Sinonasal intestinal-type adenocarcinoma is strongly associated with hardwood dust exposure. Non-intestinal-type adenocarcinoma is a rarer and less well-known subtype considered not to be related with wood dust exposure. We determined the relative numbers of these two tumor types in 56 sinonasal adenocarcinoma patients in France and Finland, relating them with carefully assessed wood dust exposure histories. Diagnostic workup including immunohistochemistry for the intestinal markers CDX2 and CK20 indicated that the proportions of the two tumors differed significantly between France and Finland. In Finnish samples non-intestinal adenocarcinomas were more common than intestinal-type adenocarcinomas (12 non-intestinal vs. nine intestinal), while in the French samples the reverse was true (six non-intestinal vs. 29 intestinal). Such remarkably dissimilar occurrence of these tumors in France and Finland presumably reflects different pathogenetic circumstances in the two countries, and perhaps their different patterns of wood dust exposure. In France the main source of wood dust is from hardwoods. In Finland it is derived from softwoods. This is the first systematic comparison of the occurrence of intestinal-type adenocarcinoma and non-intestinal-type adenocarcinoma in two countries with different wood usage. It appears to be the first systematic study on differences in wood dust exposure between intestinal-type adenocarcinoma and non-intestinal-type adenocarcinoma.

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Wood dust–related mutational profile of TP53 in intestinal-type sinonasal adenocarcinoma

Human Pathology ◽

10.1016/j.humpath.2012.01.016 ◽

2012 ◽

Vol 43 (11) ◽

pp. 1894-1901 ◽

Cited By ~ 26

Author(s):

Jhudit Pérez-Escuredo ◽

Jorge García Martínez ◽

Blanca Vivanco ◽

César Álvarez Marcos ◽

Carlos Suárez ◽

...

Keyword(s):

Intestinal Type ◽

Wood Dust ◽

Sinonasal Adenocarcinoma

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A Case of Papillary Intestinal Type Sinonasal Adenocarcinoma of the Nasal Cavity

Korean Journal of Otorhinolaryngology - Head and Neck Surgery ◽

10.3342/kjorl-hns.2013.56.5.310 ◽

2013 ◽

Vol 56 (5) ◽

pp. 310 ◽

Cited By ~ 1

Author(s):

Chan Goo Lee ◽

Young Joo Park ◽

Susie Chin ◽

Jae Yong Lee

Keyword(s):

Nasal Cavity ◽

Intestinal Type ◽

Sinonasal Adenocarcinoma

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Recurrent DNA copy number alterations in intestinal-type sinonasal adenocarcinoma

Rhinology Journal ◽

10.4193/rhino15.382 ◽

2016 ◽

Vol 54 (3) ◽

pp. 278-286

Author(s):

J. Perez-Escuredo ◽

A. Lopez-Hernandez ◽

M. Costales ◽

F. Lopez ◽

S.P. Ares ◽

...

Keyword(s):

Clinical Outcome ◽

Copy Number ◽

Genetic Alterations ◽

Intestinal Type ◽

Dust Exposure ◽

Copy Number Alterations ◽

A Genome ◽

Sinonasal Adenocarcinoma ◽

Gains And Losses ◽

Microarray Cgh

Background: Intestinal-type sinonasal adenocarcinoma (ITAC) is a rare tumour related to occupational wood dust exposure. Few studies have described recurrent genetic changes on a genome-wide scale. The aim of this study was to obtain a high resolution map of recurrent genetic alterations in ITAC. Material and methods: Copy number alterations were evaluated by microarray CGH and MLPA in 37 primary tumours. The results were correlated with pathological characteristics and clinical outcome. Results: Microarray CGH identified the following recurrent aberrations, in descending order: gains at 5p15 (22 cases, 60%), 8q24 (21 cases, 57%), 20q13 (20 cases, 54%), 20q11, and 8q21 (19 cases, 51%), 20p13, and 7p11 (16 cases, 43%), and losses at 5q11-qter, 8p12-pter, and 18q12-23 (15 cases, 40%), and 17p13, and 19p13 (13 cases, 35%). MLPA analysis confirmed this global pattern of gains and losses. Chromosomal loss at 4q32-ter and gains at 1q22, 6p22 and 3q29, as well as deletion of TIMP2 and CRK correlated with unfavourable clinical outcome. Conclusion: ITACs have a unique pattern of chromosomal abnormalities. The four different histological subtypes of ITAC appeared genetically similar. Four chromosomal gains and losses and two specific genes showed prognostic value and may be involved in tumour progression.

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