scholarly journals Rare Sinonasal Non-intestinal Type Adenocarcinoma of Right Nasal Septum

2019 ◽  
Vol 3 (1) ◽  
pp. 43
Author(s):  
Adam Mohamad ◽  
Baharudin Abdullah ◽  
Seoparjoo Azmel Mohd Isa ◽  
Norhafizah Abdul Rahim
Keyword(s):  
Nasal Septum ◽  
Young Male ◽  
Intestinal Type ◽  
Low Grade ◽  
Anatomic Structure ◽  
Respiratory Epithelial Adenomatoid Hamartoma ◽  
Seromucinous Hamartoma ◽  
Obstructive Sleep ◽  
Sinonasal Adenocarcinoma ◽  
The Right

Sinonasal tract is a complex anatomic structure with many possible diagnoses. Common diagnoses that usually encountered from the biopsied samples are inflammatory polyps and papillomas as well as squamous cell carcinoma. Another entity which most poorly understood is low grade glandular or tubular proliferations which includes reactive lesions, respiratory epithelial adenomatoid hamartoma, seromucinous hamartoma, and low grade sinonasal adenocarcinoma. We describe a case of a young male with right nasal septum mass which found incidentally upon flexible nasopharyngolaryngoscopic examination, who was referred earlier for possible obstructive sleep apnea. After excision of the tumour was done, it was confirmed to be low grade sinonasal adenocarcinoma non-intestinal type. This case highlights the rarity of the entitiy of low grade sinonasal adenocarcinoma nonintestinal type involving the right nasal septum; and how its subtle finding can be mistaken to be a clinically benign condition.International Journal of Human and Health Sciences Vol. 03 No. 01 January’19. Page : 43-46

scholarly journals Respiratory epithelial adenomatoid hamartoma: a diagnostic challenge in sinonasal lesions

2019 ◽  
Vol 12 (8) ◽  
pp. e230082
Author(s):  
Shailesh Ramesh Agrawal ◽  
Anagha Atul Joshi ◽  
Nikhil Dhorje ◽  
Renuka Bradoo
Keyword(s):  
Nasal Cavity ◽  
Nasal Septum ◽  
Low Grade ◽  
Diagnostic Challenge ◽  
Posterior Aspect ◽  
Respiratory Epithelial Adenomatoid Hamartoma ◽  
Complete Surgical Resection ◽  
Sinonasal Adenocarcinoma ◽  
Rare Lesion ◽  
Respiratory Epithelial

Respiratory epithelial adenomatoid hamartoma (REAH) is a rare lesion in nasal cavity first reported by Wenig and Heffner in 1995. Most commonly seen in men in third to ninth decade of life. Majority of cases presents as a polypoidal mass in one or both nasal cavities. We experienced such a case of REAH originating from the nasal septum, in posterior aspect, treated by endoscopic approach. It is important to differentiate REAH from other sinonasal pathologies like inverted papilloma and low grade sinonasal adenocarcinoma. Complete surgical resection is the treatment of choice.

scholarly journals A Case of the Low-Grade, Non-Intestinal type Sinonasal Adenocarcinoma of Nasal Septum

2017 ◽  
Vol 24 (1) ◽  
pp. 56
Author(s):  
Joo Hyun Shin ◽  
Ki Hwan Kwak ◽  
Jin Geol Lee ◽  
Tae Hoon Kim
Keyword(s):  
Nasal Septum ◽  
Intestinal Type ◽  
Low Grade ◽  
Sinonasal Adenocarcinoma

Intestinal-type sinonasal adenocarcinoma: a sporadic case

1996 ◽  
Vol 110 (8) ◽  
pp. 805-810 ◽  
Author(s):  
Andrej Böör ◽  
Ivan Jurkovič ◽  
Katarína Dudríková ◽  
Vojtech Kavečanský ◽  
Imrich Friedmann
Keyword(s):  
Nasal Septum ◽  
Chromogranin A ◽  
Sporadic Case ◽  
Intestinal Type ◽  
Wood Dust ◽  
Tubular Adenocarcinoma ◽  
Dust Inhalation ◽  
Sinonasal Adenocarcinoma ◽  
History Of ◽  
Columnar Cells

AbstractA sporadic case of the intestinal-type sinonasal adenocarcinoma is described. The patient was a comparatively young 33-year-old woman employed as a senior biochemical scientific technologist for several years. The light microscopical pattern was that of a papillary-tubular adenocarcinoma with areas of more solid mucinous elements in the deeper parts of the neoplasm. The neoplasm had invaded the nasal septum and reached the left orbit invading the left ethmoidal sinus. The glands were lined by columnar cells with elongated spindle-shaped nuclei and the cells expressed cytokeratin, carcinoembryonic antigen (CEA), Chromogranin A, gastrin and serotonin but not neurone-specific enolase (NSE) nor synaptophysin. Neurosecretory granules were present. There was no history of wood dust inhalation and her exposure to chemicals is of some interest but had probably little or no role in the causation of this neoplasm.

scholarly journals Keratoacanthoma of the Nasal Septum Secondary to Ranibizumab Use

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Jason E. Cohn ◽  
Hilary M. Caruso Sales ◽  
Giang Huong Nguyen ◽  
Harvey Spector ◽  
Kenneth Briskin
Keyword(s):  
Nasal Septum ◽  
Skin Lesions ◽  
Low Grade ◽  
Cutaneous Lesions ◽  
Epithelial Tumor ◽  
Vegf Inhibitor ◽  
Central Crater ◽  
Well Differentiated ◽  
The Right ◽  
Endothelial Growth Factor

Keratoacanthoma (KA) is a benign epithelial tumor that typically presents as a firm, cone-shaped, flesh-colored nodule with a central horn-filled crater. KA is considered to be a low-grade variant of squamous cell carcinoma (SCC). We report a rare case of a 72-year-old male who presented with a KA involving the nasal septum, possibly related to ranibizumab use. A flesh-colored lesion on the right anterior nasal septum lesion was visualized on examination. Histologic examination revealed a well-circumscribed, dome-shaped central crater filled with keratin, well-differentiated squamous epithelium with ground-glass cytoplasm with pushing margins, and intraepithelial microabscesses establishing the diagnosis of KA. KA of the nasal septum has only been reported once in the literature. This case is unusual because it normally presents on sun-exposed areas. Additionally, this patient was taking ranibizumab, a vascular endothelial growth factor (VEGF) inhibitor for macular degeneration. Despite ranibizumab not being directly linked to precancerous and cancerous skin lesions, agents in this medication class have been. Although it is difficult to prove associations in this isolated case, the role of ranibizumab causing cutaneous lesions should be further investigated.

scholarly journals LOW-GRADE MUCINOUS SINONASAL ADENOCARCINOMA NON-INTESTINAL TYPE: A CASE REPORT

2019 ◽  
Vol 128 (1) ◽  
pp. e75
Author(s):  
Mr. Salvador DomÍnguez-DÍaz ◽  
Dr. Javier Portilla-Robertson ◽  
Dr. Roberto Onner Cruz Tapia ◽  
Dr. Adriana Molotla-fragoso
Keyword(s):  
Case Report ◽  
Type A ◽  
Intestinal Type ◽  
Low Grade ◽  
Sinonasal Adenocarcinoma

scholarly journals A Case of Glomangiopericytoma at the Nasal Septum

2017 ◽  
Vol 12 (4) ◽  
pp. 572-575 ◽  
Author(s):  
Takashi Anzai ◽  
Tsuyoshi Saito ◽  
Sho Tsuyama ◽  
Miri Toh ◽  
Katsuhisa Ikeda ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Nasal Septum ◽  
Low Grade ◽  
Beta Catenin ◽  
Mesenchymal Neoplasm ◽  
Resected Tumor ◽  
Vascular Structures ◽  
Borderline Malignancy ◽  
Fibrous Tumor ◽  
The Right

Abstract Glomangiopericytoma (GPC) is a rare sinonasal perivascular tumor that accounts for < 0.5–1% of all sinonasal tumors. GPC is categorized as a low-grade neoplasm with borderline malignancy and a tendency of local recurrence. GPC is a rare mesenchymal neoplasm characterized by the perivascular proliferation of tumor cells, and it requires being distinguished from solitary fibrous tumors. Here, we report a case of GPC in a 68-year-old male patient who presented at the emergency room of our hospital with a complaint of sudden epistaxis. A small, reddish, protruding tumor was observed on the right nasal septum. A biopsy revealed a possible perivascular tumor such as a GPC or solitary fibrous tumor. Thus, we performed complete resection with endoscopic surgery. The size of the resected tumor was 12 × 5 mm, and it showed a uniform proliferation of oval-to-short spindle-shaped cells with slightly branching vascular structures. The tumor cells showed minimal cytologic atypia and there were an average of 3 mitoses in 10 high power fields. Necrosis was not observed. The tumor cells showed strong and diffuse nuclear immunostaining with beta catenin and were negative with STAT6, CD34 and bcl-2. The MIB-1 labeling index was approximately 5%. Genetic testing revealed CTNNB1 mutation (p.S33C). Thus, a diagnosis of low grade GPC was made on the biopsy and the patient could be successfully treated with endoscopic resection.

scholarly journals Olfactory Preservation in Craniofacial Resection of Tumor Invading Hemianterior Skull Base: Operative Video

2021 ◽  
Author(s):  
Kenya Kobayashi ◽  
Yasuji Miyakita ◽  
Fumihiko Matsumoto ◽  
Go Omura ◽  
Satoko Matsumura ◽  
...  
Keyword(s):  
Skull Base ◽  
Nasal Septum ◽  
Cribriform Plate ◽  
Cerebrospinal Fluid Leakage ◽  
Low Grade ◽  
High Grade ◽  
Craniofacial Resection ◽  
Grade Malignancy ◽  
The Right ◽  
High Grade Malignancy

AbstractIn traditional craniofacial resection of tumors invading the anterior skull base, the bilateral olfactory apparatus is resected. Recently, transnasal endoscopy has been used for olfactory preservation in resections of unilateral low-grade malignancies. However, for tumors that invade the orbita or for high-grade malignancies, the transnasal endoscopic skull base surgery has been controversial. This video demonstrates the surgical techniques of olfactory preservation during craniofacial resection of a high-grade malignancy invading the hemianterior skull base and orbita.We present the case of a 32-year-old woman with osteosarcoma in the right ethmoid sinus. The tumor invaded the ipsilateral cribriform plate, dura menta, and orbital periosteum; however, the nasal septum and crista galli were intact (Fig. 1A, B). Because the tumor was a high-grade malignancy and the orbita had been invaded, we performed craniofacial resection instead of endoscopic resection (Fig. C2A). We drilled into the right side of the crista galli, midline of the cribriform plate, and perpendicular plate of the ethmoid bone via craniotomy. As a result, we accessed the nasal cavity directly (Fig. 2B). To preserve the nasal septum, we detached the remaining right septal mucosa through the transfacial approach (Fig. 2C). Because of the high risk of cerebrospinal fluid leakage as a result of previous irradiation, we performed vascularized free flap reconstruction of the skull base instead of pericranial flap.Postoperative computed tomography revealed no evidence of tumor (Fig. 1C, D). The patient's sense of smell returned after 1 postoperative day, and she was discharged on the postoperative day 14.The link to the video can be found at: https://youtu.be/XzPABYwzkjs.

scholarly journals Intestinal-Type Sinonasal Adenocarcinoma: A Rare Entity with Review of Literature

2015 ◽  
Vol 01 ◽  
pp. 26
Author(s):  
Dhiraj Daga ◽  
Rohitashwa Dana ◽  
Shweta Mutha ◽  
◽  
◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Digestive Tract ◽  
Intestinal Type ◽  
Age Group ◽  
Rare Entity ◽  
Review Of Literature ◽  
Extensive Disease ◽  
Sinonasal Adenocarcinoma ◽  
Cranial Fossa ◽  
The Right

Intestinal-type sinonasal adenocarcinoma accounts for about 3% of cancers of the upper aero-digestive tract. It is commonly seen in men in the age group of 55-60 years. We present the case of a 60-year-old woman having extensive disease in the right half of the nasal cavity extending to the dura of the anterior cranial fossa, and the right orbital contents. The patient was given induction chemotherapy to make the condition surgically amenable, but the regression was modest, and hence she has been put on concurrent chemo-radiotherapy.

Transformation from Sinonasal Seromucinous Hamartoma to Adenocarcinoma: A Case Report

ORL ◽  
2021 ◽  
pp. 1-3
Author(s):  
David A. Rengifo ◽  
Varun V. Varadarajan ◽  
Jinping Lai ◽  
Jeb M. Justice
Keyword(s):  
Malignant Transformation ◽  
Middle Turbinate ◽  
Sinus Surgery ◽  
Low Grade ◽  
Complete Excision ◽  
Nasal Mass ◽  
Respiratory Epithelial Adenomatoid Hamartoma ◽  
Seromucinous Hamartoma ◽  
First Case ◽  
Risk Of Malignancy

<b><i>Objectives:</i></b> Sinonasal hamartomas are benign neoplasms composed of disorganized mature tissue elements. Epithelial variants include respiratory epithelial adenomatoid hamartoma (REAH) and seromucinous hamartoma (SMH). Malignant transformation of REAH is rarely reported; however, the malignant transformation of SMH to adenocarcinoma has not been described. We report the first case of a transformation from SMH to adenocarcinoma. <b><i>Methods:</i></b> The medical records of a patient presenting with sinonasal SMH with malignant transformation to adenocarcinoma were reviewed. The NCBI database was queried for the literature regarding SMH and malignant transformation of sinonasal hamartomas. <b><i>Results:</i></b> A 39-year-old man presented with a left nasal mass, nasal obstruction, and epistaxis. Computed tomography and magnetic resonance imaging demonstrated a nonaggressive and heterogeneous left nasal mass with involvement of the middle turbinate and posterior ethmoid sinuses. He underwent endoscopic sinus surgery with complete excision of the mass. Pathology revealed SMH with focal areas of transition to low-grade adenocarcinoma characterized by stromal invasion but no bony, perineural, or lymphovascular invasion. Adjuvant treatment was not recommended. Literature review revealed no reported cases of malignant transformation of SMH. <b><i>Conclusion:</i></b> We report the first case of malignant transformation of SMH. Patients with SMH must be counseled that there is an extremely rare and potentially unrecognized risk of malignancy that may influence treatment and postoperative monitoring.

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