Significance of pre-epiglottic space invasion in supracricoid partial laryngectomy with cricohyoidopexy

2007 ◽  
Vol 122 (6) ◽  
pp. 623-627 ◽  
Author(s):  
Y Suoglu ◽  
M Guven ◽  
E Kiyak ◽  
M Enoz
Keyword(s):  
Overall Survival ◽  
Anterior Commissure ◽  
Primary Tumour ◽  
Univariate Analysis ◽  
Thyroid Cartilage ◽  
Second Primary ◽  
Partial Laryngectomy ◽  
Supracricoid Partial Laryngectomy ◽  
Second Primary Tumour ◽  
Minimal Invasion

AbstractCancerous involvement of the pre-epiglottic space has been known for many years to be an important prognostic factor. The aim of this study was to investigate the prognostic value of pre-epiglottic space invasion, according to the degree of invasion (i.e. absence, minimal or gross), and to assess the oncological suitability for supracricoid partial laryngectomy in patients with supraglottic laryngeal carcinomas. This study included 52 patients with squamous cell carcinomas of the supraglottic and glotto-supraglottic larynx, treated with supracricoid partial laryngectomy–cricohyoidopexy, between 1992 and 2001. Clinical and histopathological parameters were evaluated. Pre-epiglottic space invasion was seen in 35 patients (67.3 per cent); there was gross invasion in seven patients and minimal invasion in 28. Neoplastic invasion of the anterior commissure was seen in 18 patients (34.6 per cent) and thyroid cartilage involvement in eight (15.4 per cent). Neoplastic spread through the extralaryngeal tissues was not seen in any patient. The five-year overall survival was 71.5 per cent for patients with gross pre-epiglottic space invasion, 82.2 per cent for those with minimal pre-epiglottic space invasion, and 76.4 per cent for those without pre-epiglottic space invasion. It was observed that gross or minimal pre-epiglottic space invasion did not have a statistically significant effect on survival. Univariate analysis showed that nodal positivity was associated with a poor prognosis. None of the other parameters analysed showed a statistically significant relationship with survival. Four (7.6 per cent) patients had local laryngeal recurrence. Distant metastasis and a second primary tumour were detected in three (5.8 per cent) and four (7.6 per cent) patients, respectively. The five-year overall survival and cause-specific survival were 78.8 and 82 per cent, respectively. Supracricoid partial laryngectomy with cricohyoidopexy can safely be performed in supraglottic and glotto-supraglottic carcinomas with minimal or gross invasion of the pre-epiglottic space which have no extralaryngeal spread. Nodal status is an important predictor affecting survival.

Simultaneous double laryngeal tumours: a diagnostic and therapeutic challenge

2021 ◽  
Vol 14 (2) ◽  
pp. e239797
Author(s):  
Fergus Cooper ◽  
Rafael Moleron ◽  
Andrea Chapman ◽  
Muhammad Shakeel
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Soft Tissue ◽  
Histological Analysis ◽  
Primary Tumour ◽  
Second Primary ◽  
Soft Tissue Tumours ◽  
Rare Presentation ◽  
Laryngeal Tumours ◽  
Second Primary Tumour

Leiomyosarcomas are soft tissue tumours that rarely occur in the larynx. This case report describes the presentation and management of a 77-year-old man referred to the otolaryngology clinic with hoarseness who was found to have a large supraglottic leiomyosarcoma after panendoscopy and biopsies. He subsequently underwent laryngectomy for treatment of this tumour but, unexpectedly, the histological analysis of the laryngectomy specimen revealed a second primary tumour in the larynx—a squamous cell carcinoma (SCC). The patient had further treatment with neck radiotherapy. Three years after treatment, there are no signs of recurrence of either tumour. This case report discusses the very few similar cases of leiomyosarcoma coexisting with SCC in the larynx, collating the evidence surrounding the treatment of this rare presentation.

Prognostic Factors in Early Glottic Carcinoma Implications for Treatment

2005 ◽  
Vol 91 (2) ◽  
pp. 182-187 ◽  
Author(s):  
Demiral Ayse Nur ◽  
Cetinayak Oguz ◽  
Erdag Taner Kemal ◽  
Eyiler Ferhat ◽  
Sarıoglu Sülen ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Treatment Time ◽  
Salvage Surgery ◽  
Anterior Commissure ◽  
The Other ◽  
Second Primary ◽  
Partial Laryngectomy ◽  
Glottic Carcinoma ◽  
T Classification ◽  
Early Glottic Carcinoma

Aim In this study we aimed to determine the prognostic factors affecting local control (LC) in limited glottic carcinoma treated with definitive radiotherapy (RT). Material and methods Between June 1991 and December 2001, 114 patients with early squamous-cell carcinoma of the glottis were treated with definitive RT at our institution. Only four (3.5%) patients were women. The median age was 60 (27-79). Fifteen percent, 72% and 13% of the patients had Tis, T1 and T2 tumors, respectively. Forty-three (37.7%) patients had anterior commissure invasion. Prior to RT 35 (31%) patients had undergone vocal cord stripping and two (2%) cordectomy. A median dose of 66 Gy (50-70.2) was given over a median period of 46 days (20-60). Univariate and multivariate analyses were performed for LC. The prognostic parameters analyzed for LC were T classification, anterior commissure involvement, total RT dose, and overall treatment time. Results Five-year local and regional control rates were 84.2% and 97.7%. RTOG grade 3-4 late side effects were observed only in one (0.9%) patient. In 15 patients with local failure, salvage treatment consisted of partial laryngectomy in eight patients and total laryngectomy in five. One of the remaining two patients was medically inoperable, and the other refused salvage surgery. In one of the three patients with regional failure, salvage surgery was applied and the other two were given palliative chemotherapy because of unresectable disease. Following salvage treatments, the ultimate five-year LC rate was 96.9% and the five-year larynx preservation rate was 91.1%. Second primary cancer was diagnosed in 17 (14.9%) patients. Only one patient developed distant metastases and two patients died of laryngeal cancer. While T2 disease and anterior commissure involvement were found to be unfavorable prognostic factors significantly influencing LC in univariate analyses, only T2 disease remained independent in multivariate analysis. Conclusion In patients with early glottic carcinoma, T classification proved to be the only independent prognostic factor affecting LC after primary radiotherapy according to the results of this study.

Frontolateral Vertical Partial Laryngectomy without Tracheotomy for Invasive Squamous Cell Carcinoma of the True Vocal Cord: A 25-Year Experience

2005 ◽  
Vol 114 (4) ◽  
pp. 314-322 ◽  
Author(s):  
Kevin T. Brumund ◽  
Emmanuel Babin ◽  
Raimundo Gutierrez-Fonseca ◽  
Stéphane Hans ◽  
Dominique Garcia ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Local Control ◽  
Anterior Commissure ◽  
Surgical Complication ◽  
Univariate Analysis ◽  
Partial Laryngectomy ◽  
Invasive Squamous Cell Carcinoma ◽  
Statistical Relationship ◽  
True Vocal Cord ◽  
Kaplan Meier

On the basis of an inception cohort of 270 patients with a previously untreated invasive squamous cell carcinoma of the true vocal cord (232 T1N0M0, 35 T2N0M0, and 3 T3N0M0) and a minimum of 3 years of follow-up, the authors analyze the oncological and functional outcomes following frontolateral vertical partial laryngectomy without tracheotomy. The 5-year Kaplan-Meier actuarial survival estimate ranged from 83.1% for T1 tumors to 67.2% for T2 tumors (p = .005). On univariate analysis, a significant statistical relationship was noted between reduced survival and the following variables: increased age, increased Charlson comorbidity index score over grade 0, increased tobacco intake, increased alcohol intake, increased T stage, local failure, nodal failure, and development of a metachronous second primary cancer. The hospital mortality rate was 0.4%. A significant postoperative surgical complication was noted in 49 patients (18.1%). The predominant significant surgical complication was wound infection (19 patients; 7%), followed by seroma and major subcutaneous emphysema. No significant statistical relationship was noted in a comparison of each significant postoperative complication (including postoperative death) with the variables under analysis. The incidence of secondary tracheotomy was 0.4%. The incidence of completion laryngectomy due to functional problems was 0%. The 5-year Kaplan-Meier actuarial local control estimate was 91% for T1 tumors and 68.7% for T2 tumors (p < .0001). Within the T1 tumors, the 5-year Kaplan-Meier actuarial local control estimate ranged from 96.2% for tumors without anterior commissure involvement to 74.7% for tumors with anterior commissure involvement (p = .0002). On univariate analysis, a significant statistical relationship was noted between an increase in local recurrence and the following variables: increased T stage, anterior commissure involvement, and pathological margin involvement. The overall disease control rate and laryngeal preservation rate were 92.9% and 93.3%, respectively.

scholarly journals Gene Expression-Based Approaches in Differentiation of Metastases and Second Primary Tumour

2010 ◽  
Vol 3 (2) ◽  
pp. 255-261 ◽  
Author(s):  
Tõnu Vooder ◽  
Kristjan Välk ◽  
Raivo Kolde ◽  
Retlav Roosipuu ◽  
Jaak Vilo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Primary Tumour ◽  
Second Primary ◽  
Second Primary Tumour

Second primary tumour following retinoblastoma

1989 ◽  
Vol 103 (7) ◽  
pp. 690-691 ◽  
Author(s):  
D. C. Berridge ◽  
A. Hitchcock ◽  
P. J. Bradley ◽  
L. Kapila
Keyword(s):  
Optic Nerve ◽  
Submandibular Gland ◽  
Radiation Field ◽  
Mucoepidermoid Carcinoma ◽  
Primary Tumour ◽  
Stage Iv ◽  
Second Primary ◽  
Radiation Fields ◽  
Second Primary Tumours ◽  
Second Primary Tumour

AbstractReported is a child who at the age of 18 months had presented with a left retinoblastoma. The lesion had involved the optic nerve (Stage IV), and was successfully treated by enucleation and radiotherapy. The radiation field did not include the mandible or the submandibular triangle. He was followed up until he left the area aged 11 years. He represented aged 12 years with a progressive swelling of the left submandibular gland. Histology of the surgically excised submandibular gland revealed a mucoepidermoid carcinoma of the submandibular gland. This case highlights the need for continual surveillance in survivors of retinoblastoma, as second primary tumours occur both within and outside of previous radiation fields. The clinical association between retinoblastoma and mucoepidermoid carcinoma of the submandibular gland has not been previously reported.

Sign in / Sign up

Export Citation Format

Share Document