Genetic profiling of second primary tumour and field cancerization of a female patient

2017 ◽  
Author(s):  
Sibel Elif Gultekin
Keyword(s):  
Female Patient ◽  
Primary Tumour ◽  
Field Cancerization ◽  
Second Primary ◽  
Genetic Profiling ◽  
Second Primary Tumour

Simultaneous double laryngeal tumours: a diagnostic and therapeutic challenge

2021 ◽  
Vol 14 (2) ◽  
pp. e239797
Author(s):  
Fergus Cooper ◽  
Rafael Moleron ◽  
Andrea Chapman ◽  
Muhammad Shakeel
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Soft Tissue ◽  
Histological Analysis ◽  
Primary Tumour ◽  
Second Primary ◽  
Soft Tissue Tumours ◽  
Rare Presentation ◽  
Laryngeal Tumours ◽  
Second Primary Tumour

Leiomyosarcomas are soft tissue tumours that rarely occur in the larynx. This case report describes the presentation and management of a 77-year-old man referred to the otolaryngology clinic with hoarseness who was found to have a large supraglottic leiomyosarcoma after panendoscopy and biopsies. He subsequently underwent laryngectomy for treatment of this tumour but, unexpectedly, the histological analysis of the laryngectomy specimen revealed a second primary tumour in the larynx—a squamous cell carcinoma (SCC). The patient had further treatment with neck radiotherapy. Three years after treatment, there are no signs of recurrence of either tumour. This case report discusses the very few similar cases of leiomyosarcoma coexisting with SCC in the larynx, collating the evidence surrounding the treatment of this rare presentation.

scholarly journals Gene Expression-Based Approaches in Differentiation of Metastases and Second Primary Tumour

2010 ◽  
Vol 3 (2) ◽  
pp. 255-261 ◽  
Author(s):  
Tõnu Vooder ◽  
Kristjan Välk ◽  
Raivo Kolde ◽  
Retlav Roosipuu ◽  
Jaak Vilo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Primary Tumour ◽  
Second Primary ◽  
Second Primary Tumour

Second primary tumour following retinoblastoma

1989 ◽  
Vol 103 (7) ◽  
pp. 690-691 ◽  
Author(s):  
D. C. Berridge ◽  
A. Hitchcock ◽  
P. J. Bradley ◽  
L. Kapila
Keyword(s):  
Optic Nerve ◽  
Submandibular Gland ◽  
Radiation Field ◽  
Mucoepidermoid Carcinoma ◽  
Primary Tumour ◽  
Stage Iv ◽  
Second Primary ◽  
Radiation Fields ◽  
Second Primary Tumours ◽  
Second Primary Tumour

AbstractReported is a child who at the age of 18 months had presented with a left retinoblastoma. The lesion had involved the optic nerve (Stage IV), and was successfully treated by enucleation and radiotherapy. The radiation field did not include the mandible or the submandibular triangle. He was followed up until he left the area aged 11 years. He represented aged 12 years with a progressive swelling of the left submandibular gland. Histology of the surgically excised submandibular gland revealed a mucoepidermoid carcinoma of the submandibular gland. This case highlights the need for continual surveillance in survivors of retinoblastoma, as second primary tumours occur both within and outside of previous radiation fields. The clinical association between retinoblastoma and mucoepidermoid carcinoma of the submandibular gland has not been previously reported.

Significance of pre-epiglottic space invasion in supracricoid partial laryngectomy with cricohyoidopexy

2007 ◽  
Vol 122 (6) ◽  
pp. 623-627 ◽  
Author(s):  
Y Suoglu ◽  
M Guven ◽  
E Kiyak ◽  
M Enoz
Keyword(s):  
Overall Survival ◽  
Anterior Commissure ◽  
Primary Tumour ◽  
Univariate Analysis ◽  
Thyroid Cartilage ◽  
Second Primary ◽  
Partial Laryngectomy ◽  
Supracricoid Partial Laryngectomy ◽  
Second Primary Tumour ◽  
Minimal Invasion

AbstractCancerous involvement of the pre-epiglottic space has been known for many years to be an important prognostic factor. The aim of this study was to investigate the prognostic value of pre-epiglottic space invasion, according to the degree of invasion (i.e. absence, minimal or gross), and to assess the oncological suitability for supracricoid partial laryngectomy in patients with supraglottic laryngeal carcinomas. This study included 52 patients with squamous cell carcinomas of the supraglottic and glotto-supraglottic larynx, treated with supracricoid partial laryngectomy–cricohyoidopexy, between 1992 and 2001. Clinical and histopathological parameters were evaluated. Pre-epiglottic space invasion was seen in 35 patients (67.3 per cent); there was gross invasion in seven patients and minimal invasion in 28. Neoplastic invasion of the anterior commissure was seen in 18 patients (34.6 per cent) and thyroid cartilage involvement in eight (15.4 per cent). Neoplastic spread through the extralaryngeal tissues was not seen in any patient. The five-year overall survival was 71.5 per cent for patients with gross pre-epiglottic space invasion, 82.2 per cent for those with minimal pre-epiglottic space invasion, and 76.4 per cent for those without pre-epiglottic space invasion. It was observed that gross or minimal pre-epiglottic space invasion did not have a statistically significant effect on survival. Univariate analysis showed that nodal positivity was associated with a poor prognosis. None of the other parameters analysed showed a statistically significant relationship with survival. Four (7.6 per cent) patients had local laryngeal recurrence. Distant metastasis and a second primary tumour were detected in three (5.8 per cent) and four (7.6 per cent) patients, respectively. The five-year overall survival and cause-specific survival were 78.8 and 82 per cent, respectively. Supracricoid partial laryngectomy with cricohyoidopexy can safely be performed in supraglottic and glotto-supraglottic carcinomas with minimal or gross invasion of the pre-epiglottic space which have no extralaryngeal spread. Nodal status is an important predictor affecting survival.

Foreign body reaction mimicking a second primary tumour of the oesophagus

2007 ◽  
Vol 122 (12) ◽  
pp. 1401-1403 ◽  
Author(s):  
J Pollock ◽  
N Beasley
Keyword(s):  
Case Report ◽  
Foreign Body ◽  
World Literature ◽  
Foreign Body Reaction ◽  
Primary Tumour ◽  
Anterolateral Thigh Flap ◽  
Second Primary ◽  
The World ◽  
Diagnostic Confusion ◽  
Second Primary Tumour

AbstractObjective:To present a significant complication of pharyngolaryngeal reconstruction, which resulted in diagnostic confusion as it mimicked a second primary tumour of the head and neck.Methods:Case report and review of the world literature.Case report:A 61-year-old man developed a granulomatous foreign body reaction, mimicking a second primary tumour, at the distal end of a salivary bypass tube, following pharyngolaryngectomy and reconstruction using a tubed anterolateral thigh flap. Clinically and radiologically, this was felt to represent a second primary tumour of the oesophagus, but biopsies revealed full thickness inflammation of the mucosa and granulation tissue. Repeat oesophagoscopy two weeks after removal of the tube showed complete resolution.Conclusion:No record of an oesophageal foreign body reaction to a Montgomery salivary bypass tube has previously been reported in the world literature. This report highlights the potential for such a lesion to cause diagnostic confusion with a second primary tumour.

Risk factors for the development of oesophageal cancer as a second primary tumour

1995 ◽  
Vol 31 (11) ◽  
pp. 1836-1839 ◽  
Author(s):  
H.K. van Halteren ◽  
B.G. Taal ◽  
H. van Tinteren ◽  
F.E. van Leeuwen
Keyword(s):  
Risk Factors ◽  
Oesophageal Cancer ◽  
Primary Tumour ◽  
Second Primary ◽  
Second Primary Tumour
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