To investigate the effect of light cue on the resetting of the
peripheral clocks, we examined the resetting processes of clock
genes (Per1, Per2, Bmal1, Cry1, Dec1, and Rev-erbα) in the liver
and heart of rats after the feeding and light-dark (LD) reversal
via a 24-h light period transition. The liver clock was reset quickly
within 3 days, while the heart clock needed a longer time course
of 5-7 days to be completely re-entrained. Moreover, the reentrainment of Per1 and Per2 in the liver clock was more rapid
than that of the other four clock genes, suggesting the important
role of these two clock genes in initiating the circadian resetting
of the hepatic clock. However, the resetting rates of these two
clock genes were as similar as the others in the heart clock.
Therefore, the resetting mechanisms underlining these two
peripheral clocks may be totally distinct. Furthermore, the reentrainment of the liver and heart clocks were relatively
lengthened after the feeding and LD reversal via a light period
transition compared to a dark period transition, suggesting a
simultaneous shift of feeding schedule and the LD cycle may
facilitate the circadian resetting in rats.