Is schizophrenia an HLA-associated disease?

1979 ◽  
Vol 9 (4) ◽  
pp. 721-728 ◽  
Author(s):  
Peter McGuffin
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Postsynaptic Membrane ◽  
Leukocyte Antigen ◽  
Hla System ◽  
Central Neurotransmitters ◽  
Disease Subtypes ◽  
The Relationship

SYNOPSISCertain specificities of the human leukocyte antigen (HLA) system have been shown to be associated with particular diseases. A review of recent studies in schizophrenia shows inconsistent results for schizophrenia as a whole, although a significant increase in HLA A28 remains on combining the data. There are more consistent findings for disease subtypes. In particular, HLA A9 and HLA CW4 are increased in paranoid schizophrenics, while HLA Al and the A1–B8 haplotype are increased in nuclear forms. It is postulated that the relationship between the schizophrenias and certain HLA types could be due to an influence of the latter upon neuronal postsynaptic membrane sensitivity to central neurotransmitters such as dopamine.

scholarly journals PIRCHE-II: an algorithm to predict indirectly recognizable HLA epitopes in solid organ transplantation

2019 ◽  
Vol 72 (1-2) ◽  
pp. 119-129 ◽  
Author(s):  
Kirsten Geneugelijk ◽  
Eric Spierings
Keyword(s):  
Human Leukocyte Antigen ◽  
Organ Transplantation ◽  
Graft Survival ◽  
Solid Organ Transplantation ◽  
Human Leukocyte ◽  
Solid Organ ◽  
Hla Alleles ◽  
Leukocyte Antigen ◽  
Hla System ◽  
Hla Mismatches

AbstractHuman leukocyte antigen (HLA) mismatches between donors and recipients may lead to alloreactivity after solid organ transplantation. Over the last few decades, our knowledge of the complexity of the HLA system has dramatically increased, as numerous new HLA alleles have been identified. As a result, the likelihood of alloreactive responses towards HLA mismatches after solid organ transplantation cannot easily be assessed. Algorithms are promising solutions to estimate the risk for alloreactivity after solid organ transplantation. In this review, we show that the recently developed PIRCHE-II (Predicted Indirectly ReCognizable HLA Epitopes) algorithm can be used to minimize alloreactivity towards HLA mismatches. Together with the use of other algorithms and simulation approaches, the PIRCHE-II algorithm aims for a better estimated alloreactive risk for individual patients and eventually an improved graft survival after solid organ transplantation.

Analysis of the distribution of alleles of the Human Leukocyte Antigen (HLA) system in Brazilian population

2017 ◽  
Author(s):  
Douglas Cescon da Rosa ◽  
ISCIA TERESINHA LOPES CENDES ◽  
Tânia K. de Araujo ◽  
FERNANDO CENDES ◽  
Nancy Watanabe ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Brazilian Population ◽  
Leukocyte Antigen ◽  
Hla System

scholarly journals The Potential of Soluble Human Leukocyte Antigen Molecules for Early Cancer Detection and Therapeutic Vaccine Design

Vaccines ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 775
Author(s):  
Amy L. Kessler ◽  
Marco J. Bruno ◽  
Sonja I. Buschow
Keyword(s):  
Human Leukocyte Antigen ◽  
Target Identification ◽  
Therapeutic Vaccine ◽  
Human Leukocyte ◽  
Full Potential ◽  
Leukocyte Antigen ◽  
Bodily Fluids ◽  
Soluble Hla ◽  
The Relationship ◽  
Hla Molecules

Human leukocyte antigen (HLA) molecules are essential for anti-tumor immunity, as they display tumor-derived peptides to drive tumor eradication by cytotoxic T lymphocytes. HLA molecules are primarily studied as peptide-loaded complexes on cell membranes (mHLA) and much less attention is given to their secretion as soluble HLA–peptide complexes (sHLA) into bodily fluids. Yet sHLA levels are altered in various pathologies including cancer, and are thus of high interest as biomarkers. Disconcordance in results across studies, however, hampers interpretation and generalization of the relationship between sHLA levels and cancer presence, thereby impairing its use as a biomarker. Furthermore, the question remains to what extent sHLA complexes exert immunomodulatory effects and whether shifts in sHLA levels contribute to disease or are only a consequence of disease. sHLA complexes can also bear tumor-derived peptides and recent advancements in mass spectrometry now permit closer sHLA peptide cargo analysis. sHLA peptide cargo may represent a “liquid biopsy” that could facilitate the use of sHLA for cancer diagnosis and target identification for therapeutic vaccination. This review aims to outline the contradictory and unexplored aspects of sHLA and to provide direction on how the full potential of sHLA as a quantitative and qualitative biomarker can be exploited.

scholarly journals The opposite effect of human leukocyte antigen genotypes in sarcoidosis and tuberculosis: a narrative review of the literature

2020 ◽  
Vol 6 (3) ◽  
pp. 00155-2020
Author(s):  
Anna Malkova ◽  
Anna Starshinova ◽  
Yulia Zinchenko ◽  
Natalia Basantsova ◽  
Vera Mayevskaya ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Narrative Review ◽  
Autoimmune Response ◽  
Review Of The Literature ◽  
Leukocyte Antigen ◽  
Online Databases ◽  
Hla Genotypes ◽  
Common Pathogenesis ◽  
The Relationship

Sarcoidosis and tuberculosis share several similar clinical and pathogenic characteristics that make some researchers consider a common pathogenesis for these diseases. Human leukocyte antigen (HLA) genotypes are studied both in sarcoidosis and tuberculosis patients, but to our knowledge, there are no comparative studies of genetic predisposition for sarcoidosis and tuberculosis development.The aim of this review was to analyse the relationship between HLA genotypes and the development of sarcoidosis and tuberculosis. Original and review articles published in various online databases from 1960 to 2019 were studied.The search results showed opposite effects of the HLA genotypes on predisposition to sarcoidosis or tuberculosis. It was revealed that the genotypes predisposing to the development of sarcoidosis (HLA-DRB1*03/07/15) have protective properties against the development of tuberculosis. Moreover, genotypes causing the development of tuberculosis (HLA-DRB1*04) have a protective effect on the development of sarcoidosis.The results of this narrative review of the literature may allude to the existence of genetic predispositions that lead to the development of an antibacterial or autoimmune response to mycobacteria.

scholarly journals Cutaneous squamous cell cancer (cSCC) risk and the human leukocyte antigen (HLA) system

2017 ◽  
Vol 78 (4) ◽  
pp. 327-335 ◽  
Author(s):  
Pooja Yesantharao ◽  
Wei Wang ◽  
Nilah M. Ioannidis ◽  
Shadmehr Demehri ◽  
Alice S. Whittemore ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Squamous Cell ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Hla System

scholarly journals Comparative analysis of DQB1 и DQA1 class II genes of human leukocyte antigen system in the population of Azerbaijan

2017 ◽  
Vol 98 (5) ◽  
pp. 704-708
Author(s):  
G A Akhmedov
Keyword(s):  
Comparative Analysis ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Class Ii ◽  
Control Group ◽  
Healthy Children ◽  
Leukocyte Antigen ◽  
Hla System ◽  
Hla Dq ◽  
Hla Dq2

Aim. To perform comparative analysis of DQB1 and DQA1 class II genes of the human leukocyte antigen (HLA) system in the population of Azerbaijan. Methods. We studied the alleles of HLA DQ gene and subtypes of HLA DRB1*04 in 160 children with diabetes mellitus and in 271 healthy children from the population of Azerbaijan. Out of 160 patients, 50.6% (n=81) were boys, 49.4% (n=79) were girls. All patients with diabetes were under the age of 18 years. As a control group, 271 students of the Medical College No. 1 were involved: 79 (29.1%) boys, 192 (70.9%) girls. The collected blood samples were sent for further investigation to the medical genetic laboratory where polymerase chain reaction-based genotyping of the samples was performed. Results. For the first time, the relationship of diabetes with class II genes of the HLA system was studied. The Azerbaijani were found to have higher risk associated with HLA DQ2 molecule. The molecule HLA DQ8 also increases risk, although it is lower in comparison with HLA DQ2 molecule. What is unusual is that for this population the allele HLA DQB1*0304 was also associated with the risk of diabetes. Conclusion. The haplotype DQB1*0302-DQA1*03/DQB1*02-DQA1*05 (DQ8/DQ2.5) associated with high risk of diabetes is found in 3% of the representatives of the population of Azerbaijan, which is estimated as the average prevalence of diabetes.

The Human Leukocyte Antigen (HLA) System: 1990

1990 ◽  
Vol 4 (4) ◽  
pp. 279-287 ◽  
Author(s):  
Christine T. McCusker ◽  
Dharam P. Singal
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Hla System
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