Laterality of visuo-spatial attention in acute and chronic schizophrenia, major depression and in healthy controls

1995 ◽  
Vol 25 (5) ◽  
pp. 1091-1095 ◽  
Author(s):  
R. E. O'Carroll ◽  
A. Rogers ◽  
S. M. Lawrie ◽  
C. Murray ◽  
M. Van Beck ◽  
...  
Keyword(s):  
Major Depression ◽  
Spatial Attention ◽  
Chronic Schizophrenia ◽  
Healthy Controls ◽  
Opposite Pattern ◽  
Chronic Schizophrenic ◽  
Schizophrenic Patients ◽  
Schizophrenic Group ◽  
Two Measures

SYNOPSISPrevious studies have suggested that schizophrenia is characterized by an asymmetry of visuo-spatial attention, in particular that acute unmedicated schizophrenics demonstrate relative inattention to right hemispace, whereas chronically medicated patients demonstrate the opposite pattern. In the present study, 30 unmedicated schizophrenic patients, 32 chronically medicated schizophrenic patients, 30 patients suffering from major depression and 60 healthy controls were assessed using two measures of hemispatial attentional neglect, namely letter and star cancellation. The results demonstrated that the chronic schizophrenic group made more total omissions for star cancellation (in both right and left hemispace), but that there was no difference between the groups in terms of omission asymmetry for either letter or star cancellation.

Immunoglobulin allotypes Gm and Km in chronic schizophrenia: no apparent association

1983 ◽  
Vol 13 (1) ◽  
pp. 27-30 ◽  
Author(s):  
David N. Propert
Keyword(s):  
Chronic Schizophrenia ◽  
Healthy Controls ◽  
Chronic Schizophrenic ◽  
Immunoglobulin Allotypes ◽  
Schizophrenic Patients ◽  
Apparent Association

SynopsisThe distribution of the immunoglobulin allotypic markers G1m(1), G1m(2), G1m(3), G3m(5) and Km(1) was determined in 168 hospitalized Caucasian chronic schizophrenic patients and compared with that in healthy controls. No association between Gm or Km phenotypes and chronic schizophrenia is apparent.

The Positive Correlation between Insulin Resistance and Duration of Hospitalization in Untreated Schizophrenia

1971 ◽  
Vol 118 (545) ◽  
pp. 429-436 ◽  
Author(s):  
Werner H. Schimmelbusch ◽  
Peter S. Mueller ◽  
Jack Sheps
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Blood Glucose ◽  
Free Fatty Acids ◽  
Chronic Schizophrenia ◽  
Intravenous Glucose ◽  
Plasma Free Fatty Acids ◽  
Chronic Schizophrenic ◽  
Duration Of Hospitalization ◽  
Schizophrenic Patients

Various abnormalities have been demonstrated in schizophrenic patients in response to injected insulin. Thomaset al.(22), Harris (8), Freemanet al.(7), Mayer-Gross (10), and Bracelandet al.(4) have shown a delayed or decreased response of blood glucose to insulin in schizophrenic patients. Meduna and McCulloch (11) observed that those schizophrenic patients who suffered from confusion and clouding of the sensorium particularly displayed a delayed or decreased response to injected insulin as well as a urinary hyperglycaemic factor and decreased tolerance to oral and intravenous glucose. Subsequent studies by Mueller (12, 13) demonstrated a rise or lack of fall in the plasma free fatty acids (FFA) following the administration of insulin intramuscularly or intravenously in chronic schizophrenic patients. Van Sickleet al.(23) confirmed these findings of insulin resistance in chronic schizophrenia and noted that this low FFA response was neither related to an abnormal release of, nor response to, epinephrine.

Gonadotrophin secretion abnormalities in chronic schizophrenia

1982 ◽  
Vol 12 (2) ◽  
pp. 263-273 ◽  
Author(s):  
I. N. Ferrier ◽  
P. M. Cotes ◽  
T. J. Crow ◽  
E. C. Johnstone
Keyword(s):  
Natural History ◽  
Clinical Features ◽  
Anterior Pituitary ◽  
Chronic Schizophrenia ◽  
Neuroleptic Medication ◽  
Acute Schizophrenia ◽  
Chronic Schizophrenic ◽  
Gonadotrophin Secretion ◽  
Schizophrenic Patients ◽  
Lh Secretion

SynopsisLH, FSH, PRL and testosterone were estimated by radioimmunoassay in serial venous samples from 20 male chronic schizophrenic patients, 17 age-matched controls, 3 patients in remission from acute schizophrenia, and in single samples from age–sex matched populations. LH and FSH, but not testosterone or PRL, were significantly reduced in patients with chronic schizophrenia. There was an associated reduction in the frequency, but not amplitude, of LH secretory episodes in patients with chronic schizophrenia. No abnormalities of LH secretion were detected in those patients in remission from acute schizophrenia. Fourteen of the chronic schizophrenic patients were retested at a later date with similar results, except in the case of the few patients who had been started on neuroleptic medication. Some relationships were established between hormonal secretion and the clinical features of these patients. The possible significance of these findings is discussed in the context of the complex control of gonadotrophin secretion from the anterior pituitary and the natural history and nature of chronic schizophrenia.

scholarly journals Neurodevelopmental correlates in schizophrenia

2003 ◽  
Vol 131 (7-8) ◽  
pp. 294-299 ◽  
Author(s):  
Maja Ivkovic ◽  
Aleksandar Damjanovic ◽  
Vladimir Paunovic
Keyword(s):  
Developmental Disorders ◽  
Healthy Controls ◽  
Birth Complications ◽  
Maternal Recall ◽  
Structural Abnormalities ◽  
Schizophrenic Patients ◽  
Schizophrenic Group ◽  
Neuro Imaging ◽  
Minor Physical Anomalies

Contemporary aetiopathogenetic considerations, based on neuro-imaging genetic and developmental neurobiology studies, suggest neurodevelopmental origin of schizophrenia. Several lines of evidence including structural abnormalities on in vivo brain imaging, the excess of prenatal and obstetric complications and the association of congenital and minor physical anomalies with schizophrenia, strongly indicate the neurodevelopmental pathogenesis of schizophrenia. On the other hand, controversial concept of psychotic continuum suggests schizophrenia and depression sharing the same genetic contribution to the pathogenesis. If this would be the case, depression could also be considered as neuro developmental disorder. The aims of the study were to investigate the association between: a) pregnancy and birth complications (PBC), and b) minor physical anomalies (MPA) and schizophrenia or depression. Experimental groups consisted of 60 schizophrenic, 28 major depression patients and 30 healthy controls. All patients were diagnosed according to DSM-IV. Schizophrenic group was divided with regard to PANSS score into positive (n=32) and negative form (n=28) subgroups. PBC information were gathered from maternal recall while MPA were examined by using Waldrop scale for adults. The results showed that negative and positive schizophrenic subgroups had significantly more PBC than depressive group (p<0,05), as well than controls (p<0,001; p<0,05; respectively). There was no significant trend for more PBC in negative than in positive subgroup. All schizophrenic patients had higher rates of MPA than depressives (p<0,05). This trend for more MPA was not significant in comparison with healthy controls. These findings suggest that schizophrenia, especially its negative forms, could be considered as a member of the spectrum of neuro developmental disorders, which does not seem to be the case with depression. PBC and MPA could also be valuable in evaluation of risks for schizophrenia and possible predictive indicators of its development.

The Significance of Stupor in the Long-Term Outcome of Chronic Schizophrenia

1989 ◽  
Vol 155 (3) ◽  
pp. 352-355 ◽  
Author(s):  
J. C. Rigby ◽  
S. M. Wood ◽  
R. H. S. Mindham
Keyword(s):  
Psychiatric Hospital ◽  
Mental State ◽  
Chronic Schizophrenia ◽  
Favourable Outcome ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Chronic Schizophrenic ◽  
Schizophrenic Patients ◽  
Similar Sample

The admission records of 271 long-stay chronic schizophrenic patients, resident in a large psychiatric hospital, were examined in order to identify those who had presented in stupor at the onset of their illness. Twelve patients were found (ten men and two women). When compared, in terms of current mental state and behaviour, with a similar sample of schizophrenics in whom stupor had been absent, significant differences between the two groups were detected, with those presenting in stupor demonstrating a less favourable outcome.

The Ventricular System in Chronic Schizophrenic Patients

1984 ◽  
Vol 144 (2) ◽  
pp. 172-176 ◽  
Author(s):  
Anand K. Pandurangi ◽  
Mantosh J. Dewan ◽  
Seungho Howard Lee ◽  
Tarakad Ramachandran ◽  
Benjamin F. Levy ◽  
...  
Keyword(s):  
Ct Scan ◽  
Cerebral Atrophy ◽  
Ventricular Enlargement ◽  
Csf Flow ◽  
Chronic Schizophrenic ◽  
The Third ◽  
Common Causes ◽  
Schizophrenic Patients ◽  
Schizophrenic Group ◽  
Occipital Lobes

SummaryTwenty-three chronic schizophrenic patients and 23 controls, all males between 20 and 40 years of age, were evaluated by CT scan. The lateral, third and fourth ventricles, the Sylvian fissures, and the largest sulcus from each of the frontal, parietal, and occipital lobes, were measured in order to determine whether the previously reported ventriculomegaly in schizophrenics was perhaps due to a disturbance of CSF flow or to atrophy, two common causes of ventricular enlargement. We found that in the schizophrenic group the third and fourth ventricles and both Sylvian fissures were significantly enlarged, but not the lateral ventricles or cerebral sulci. Our data suggest that these ventricular changes are not due to a disturbance of CSF flow or to cerebral atrophy. Other possible explanations are discussed.

scholarly journals High Order Linguistic Features Such as Ambiguity Processing as Relevant Diagnostic Markers for Schizophrenia

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Daniel Ketteler ◽  
Anastasia Theodoridou ◽  
Simon Ketteler ◽  
Matthias Jäger
Keyword(s):  
High Order ◽  
Test Battery ◽  
Healthy Controls ◽  
Linguistic Features ◽  
Performance Deficits ◽  
Linguistic Performance ◽  
Order Language ◽  
Function Test ◽  
Schizophrenic Patients ◽  
Schizophrenic Group

Due to the deficits of schizophrenic patients regarding the understanding of vague meanings (D. Ketteler and S. Ketteler (2010)) we develop a special test battery called HOLF (high order linguistic function test), which should be able to detect subtle linguistic performance deficits in schizophrenic patients. HOLF was presented to 40 schizophrenic patients and controls, focussing on linguistic features such as ambiguity, synonymy, hypero-/hyponymy, antinomy, and adages. Using the HOLF test battery we found that schizophrenic patients showed significant difficulties in discriminating ambiguities, hypero- and hyponymy, or synonymy compared to healthy controls. Antonyms and adages showed less significant results in comparing both groups. The more difficult a linguistic task was, the more confusion was measured in the schizophrenic group while healthy controls did not show significant problems in processing high order language tasks.

Two kinds of cognitive deficit associated with chronic schizophrenia

1977 ◽  
Vol 7 (1) ◽  
pp. 171-173 ◽  
Author(s):  
C. D. Frith
Keyword(s):  
Feature Selection ◽  
Negative Symptoms ◽  
Cognitive Deficit ◽  
Chronic Schizophrenia ◽  
Positive Symptoms ◽  
Chronic Schizophrenic ◽  
Normal Degree ◽  
Schizophrenic Patients

SynopsisThe performance of 21 chronic schizophrenic patients was investigated on two tests of feature selection. It was found that patients with negative symptoms (muteness, withdrawal, etc.) were characterized by an extreme lack of persistence, but selected usual features; whereas patients with positive symptoms (hallucinations, delusions, etc.) had a normal degree of persistence, but selected unusual features.

Confabulation in schizophrenia and its relationship to clinical and neuropsychological features of the disorder

2007 ◽  
Vol 37 (10) ◽  
pp. 1403-1412 ◽  
Author(s):  
E. LORENTE-ROVIRA ◽  
E. POMAROL-CLOTET ◽  
R. A. McCARTHY ◽  
G. E. BERRIOS ◽  
P. J. McKENNA
Keyword(s):  
Semantic Memory ◽  
Memory Impairment ◽  
Chronic Schizophrenia ◽  
Recall Task ◽  
Thought Disorder ◽  
Healthy Controls ◽  
Intellectual Impairment ◽  
Neurological Patients ◽  
Schizophrenic Patients ◽  
Executive Impairment

ABSTRACTBackgroundA form of confabulation has been documented in schizophrenia and appears to be related to the symptom of thought disorder. It is unclear whether it is associated with the same pattern of neuropsychological deficits as confabulation in neurological patients.MethodThirty-four patients with chronic schizophrenia, including those with and without thought disorder, and 17 healthy controls were given a fable recall task to elicit confabulation. They were also examined on a range of executive, episodic and semantic memory tests.ResultsConfabulation was seen at a significantly higher rate in the schizophrenic patients than the controls, and predominated in those with thought disorder. Neuropsychologically, it was not a function of general intellectual impairment, and was not clearly related to episodic memory or executive impairment. However, there were indications of an association with semantic memory impairment.ConclusionsThe findings support the existence of a form of confabulation in schizophrenia that is related to thought disorder and has a different neuropsychological signature to the neurological form of the symptom.

Hedonic Deficit in Chronic Schizophrenia

1979 ◽  
Vol 9 (3) ◽  
pp. 227-237
Author(s):  
A. L. C. Pottash ◽  
Marks Gold ◽  
Margaret Pottenger ◽  
Brigitte A. Prusoff
Keyword(s):  
Chronic Schizophrenia ◽  
Matched Sample ◽  
Chronic Schizophrenic ◽  
Schizophrenic Patients

Forty-two chronic schizophrenic patients were evaluated for extent of hedonic deficit and compared with a demographically matched sample of normals. Schizophrenics rated themselves as experiencing significantly less pleasure on four of ten pleasure factors. When the schizophrenic sample was divided into depressed and non-depressed subgroups, the depressed subgroup was found to account for these differences in pleasure between schizophrenics and normals. Psychobiological implications of these results are discussed.

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