The Positive Correlation between Insulin Resistance and Duration of Hospitalization in Untreated Schizophrenia

1971 ◽  
Vol 118 (545) ◽  
pp. 429-436 ◽  
Author(s):  
Werner H. Schimmelbusch ◽  
Peter S. Mueller ◽  
Jack Sheps
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Blood Glucose ◽  
Free Fatty Acids ◽  
Chronic Schizophrenia ◽  
Intravenous Glucose ◽  
Plasma Free Fatty Acids ◽  
Chronic Schizophrenic ◽  
Duration Of Hospitalization ◽  
Schizophrenic Patients

Various abnormalities have been demonstrated in schizophrenic patients in response to injected insulin. Thomaset al.(22), Harris (8), Freemanet al.(7), Mayer-Gross (10), and Bracelandet al.(4) have shown a delayed or decreased response of blood glucose to insulin in schizophrenic patients. Meduna and McCulloch (11) observed that those schizophrenic patients who suffered from confusion and clouding of the sensorium particularly displayed a delayed or decreased response to injected insulin as well as a urinary hyperglycaemic factor and decreased tolerance to oral and intravenous glucose. Subsequent studies by Mueller (12, 13) demonstrated a rise or lack of fall in the plasma free fatty acids (FFA) following the administration of insulin intramuscularly or intravenously in chronic schizophrenic patients. Van Sickleet al.(23) confirmed these findings of insulin resistance in chronic schizophrenia and noted that this low FFA response was neither related to an abnormal release of, nor response to, epinephrine.

Plasma Free Fatty Acids Before and After an Intravenous Insulin Injection in Acute Schizophrenic Men

1970 ◽  
Vol 116 (531) ◽  
pp. 173-177 ◽  
Author(s):  
G. Franzén
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Sympathetic Activity ◽  
Close Relation ◽  
Insulin Injection ◽  
Healthy Controls ◽  
Plasma Free Fatty Acids ◽  
Intravenous Insulin ◽  
Before And After ◽  
Schizophrenic Patients

The possibility of abnormalities in carbohydrate metabolism in schizophrenia has been stressed by many authors (Mann 1925, Freeman et al., 1943, Braceland et al., 1945, Morgan and Pilgrim 1952, Henneman et al., 1954, Moya et al., 1958, Lingjaerde and Skaug 1959). As there is a close relation between lipid metabolism (in terms of plasma free fatty acids, FFA) and glucose metabolism Mueller (1961, 1962) tested the FFA-response to insulin-induced hypoglycaemia in chronic schizophrenic patients. He found that schizophrenics showed less reduction in FFA-values than healthy controls, in some cases even an increase. Results were later presented which tend to confirm Mueller's data (van Sickle et al., 1966). Interest was focused on increased sympathetic activity in the patients, and infusion experiments with epinephrine (van Sickle et al., 1966) and norepinephrine (Cardon and Mueller 1964) were performed without producing conclusive results.

In vivo regulation of plasma free fatty acids in insulin resistance

Metabolism ◽  
2004 ◽  
Vol 53 (9) ◽  
pp. 1197-1201 ◽  
Author(s):  
S. Mook ◽  
C.J.M. Halkes ◽  
S. Bilecen ◽  
M.Castro Cabezas
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Plasma Free Fatty Acids

Plasma free fatty acids in exercise

1964 ◽  
Vol 19 (3) ◽  
pp. 489-492 ◽  
Author(s):  
K. Rodahl ◽  
H. I. Miller ◽  
B. Issekutz
Keyword(s):  
Fatty Acids ◽  
Lipid Metabolism ◽  
Blood Glucose ◽  
Free Fatty Acids ◽  
Blood Sugar ◽  
Blood Lactate ◽  
Marked Change ◽  
Apparent Discrepancy ◽  
Plasma Free Fatty Acids ◽  
Plasma Ffa

The effects of exercise of different intensity and duration on plasma free fatty acids (FFA), blood glucose, and lactate were investigated in eight healthy young men. In heavy 10-min work the blood lactate rose rapidly and the FFA decreased. Blood sugar showed no marked change. Intermittent work caused a slight increase in blood lactate and no change in blood glucose. The FFA remained essentially unchanged but increased in three out of four subjects during recovery. In moderate 1-hr work the FFA remained essentially unchanged, but increased markedly during recovery when blood lactate had returned to resting levels. In prolonged exhausting work in fasting subjects, the blood lactate remained almost unchanged, while the FFA rose steadily and the blood sugar dropped. In nonfasting subjects the FFA also rose, but the ingestion of lunch caused, in all cases, a striking drop in the FFA, associated with a rise in blood sugar. Combined hormonal effects (insulin and norepinephrine) brought into play during exercise of different intensity and duration may well explain the apparent discrepancy in the results of different investigators concerning the effect of exercise on plasma FFA. work and FFA; FFA at different workloads; lipid metabolism in work Submitted on November 6, 1963

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