The relationship between obsessive–compulsive disorder and anxiety and affective disorders: results from the Johns Hopkins OCD Family Study

2001 ◽  
Vol 31 (3) ◽  
pp. 481-487 ◽  
Author(s):  
G. NESTADT ◽  
J. SAMUELS ◽  
M. A. RIDDLE ◽  
K.-Y. LIANG ◽  
O. J. BIENVENU ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Obsessive Compulsive Disorder ◽  
Affective Disorders ◽  
Substance Dependence ◽  
Separation Anxiety ◽  
Family Study ◽  
Separation Anxiety Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
The Relationship

Objective. This study investigates the relationship of specific anxiety and affective disorders to obsessive–compulsive disorder (OCD) in a blind, controlled family study.Method. Eighty case and 73 control probands, as well as 343 case and 300 control first-degree relatives of these probands, participated in the study. Subjects were examined by psychologists or psychiatrists using the Schedule for Affective Disorder and Schizophrenia-Lifetime Anxiety version (SADS-LA). Two experienced psychiatrists independently reviewed all clinical materials, and final diagnoses were made according to DSM-IV criteria, by consensus procedure.Results. Except for bipolar disorder, all anxiety and affective disorders investigated were more frequent in case than control probands. Substance dependence disorders were not more frequent. Generalized anxiety disorder (GAD), panic disorder, agoraphobia, separation anxiety disorder (SAD) and recurrent major depression were more common in case than control relatives. These disorders occurred more frequently if the relative was diagnosed with OCD. Only GAD and agoraphobia were more frequent in case relatives independent of OCD.Conclusion. GAD and agoraphobia share a common familial aetiology with OCD. The other anxiety and affective disorders, when comorbid with OCD, may emerge as a consequence of the OCD or as a more complex syndrome.

Obsessive–compulsive disorder and separation anxiety co-morbidity in early onset panic disorder

2001 ◽  
Vol 31 (7) ◽  
pp. 1307-1310 ◽  
Author(s):  
R. GOODWIN ◽  
J. D. LIPSITZ ◽  
T. F. CHAPMAN ◽  
S. MANNUZZA ◽  
A. J. FYER
Keyword(s):  
Anxiety Disorder ◽  
Panic Disorder ◽  
Obsessive Compulsive Disorder ◽  
Separation Anxiety ◽  
Age Of Onset ◽  
Separation Anxiety Disorder ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Co Morbidity

Background. This study was undertaken to examine the relationship between anxiety co-morbidity and age of onset of panic disorder.Methods. Age of onset of panic disorder and co-morbid anxiety disorders were assessed among 201 panic disorder probands with childhood separation anxiety disorder, obsessive–compulsive disorder, obsessive–compulsive symptoms, social phobia and specific phobia as part of a clinician-administered lifetime diagnostic interview. A generalized linear model was used to test the association between each anxiety co-morbidity and age of panic disorder onset while simultaneously controlling for the potential confounding effects of sociodemographic characteristics and other psychiatric co-morbidity.Results. Earlier onset of panic disorder was found in patients with co-morbid obsessive–compulsive disorder, obsessive–compulsive symptoms and separation anxiety disorder, but not simple phobia or social phobia. Patients with both childhood separation anxiety disorder and obsessive–compulsive disorder had an even earlier panic onset than those with either childhood separation anxiety disorder or obsessive–compulsive disorder.Conclusions. The association between anxiety co-morbidity and earlier onset of panic disorder is specific to obsessive–compulsive disorder and childhood separation anxiety disorder.

Separation anxiety disorder in adult patients with obsessive-compulsive disorder: Prevalence and clinical correlates

2015 ◽  
Vol 30 (1) ◽  
pp. 145-151 ◽  
Author(s):  
A.P. Franz ◽  
L. Rateke ◽  
T. Hartmann ◽  
N. McLaughlin ◽  
A.R. Torres ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Obsessive Compulsive Disorder ◽  
Separation Anxiety ◽  
Symptom Assessment ◽  
Separation Anxiety Disorder ◽  
Response To Treatment ◽  
Obsessive Compulsive ◽  
Cross Sectional ◽  
Psychiatric Comorbidities ◽  
Compulsive Disorder

AbstractObjective:Individuals with obsessive-compulsive disorder (OCD) and separation anxiety disorder (SAD) tend to present higher morbidity than do those with OCD alone. However, the relationship between OCD and SAD has yet to be fully explored.Method:This was a cross-sectional study using multiple logistic regression to identify differences between OCD patients with SAD (OCD + SAD, n = 260) and without SAD (OCD, n = 695), in terms of clinical and socio-demographic variables. Data were extracted from those collected between 2005 and 2009 via the Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders project.Results:SAD was currently present in only 42 (4.4%) of the patients, although 260 (27.2%) had a lifetime diagnosis of the disorder. In comparison with the OCD group patients, patients with SAD + OCD showed higher chance to present sensory phenomena, to undergo psychotherapy, and to have more psychiatric comorbidities, mainly bulimia.Conclusion:In patients with primary OCD, comorbid SAD might be related to greater personal dysfunction and a poorer response to treatment, since sensory phenomena may be a confounding aspect on diagnosis and therapeutics. Patients with OCD + SAD might be more prone to developing specific psychiatric comorbidities, especially bulimia. Our results suggest that SAD symptom assessment should be included in the management and prognostic evaluation of OCD, although the psychobiological role that such symptoms play in OCD merits further investigation.

scholarly journals Obsessive–compulsive disorder: subclassification based on co-morbidity

2008 ◽  
Vol 39 (9) ◽  
pp. 1491-1501 ◽  
Author(s):  
G. Nestadt ◽  
C. Z. Di ◽  
M. A. Riddle ◽  
M. A. Grados ◽  
B. D. Greenberg ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Obsessive Compulsive Disorder ◽  
Clinical Characteristics ◽  
Latent Class ◽  
Age At Onset ◽  
Separation Anxiety Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Co Morbidity ◽  
The Relationship

BackgroundObsessive–compulsive disorder (OCD) is probably an etiologically heterogeneous condition. Many patients manifest other psychiatric syndromes. This study investigated the relationship between OCD and co-morbid conditions to identify subtypes.MethodSeven hundred and six individuals with OCD were assessed in the OCD Collaborative Genetics Study (OCGS). Multi-level latent class analysis was conducted based on the presence of eight co-morbid psychiatric conditions [generalized anxiety disorder (GAD), major depression, panic disorder (PD), separation anxiety disorder (SAD), tics, mania, somatization disorders (Som) and grooming disorders (GrD)]. The relationship of the derived classes to specific clinical characteristics was investigated.ResultsTwo and three classes of OCD syndromes emerge from the analyses. The two-class solution describes lesser and greater co-morbidity classes and the more descriptive three-class solution is characterized by: (1) an OCD simplex class, in which major depressive disorder (MDD) is the most frequent additional disorder; (2) an OCD co-morbid tic-related class, in which tics are prominent and affective syndromes are considerably rarer; and (3) an OCD co-morbid affective-related class in which PD and affective syndromes are highly represented. The OCD co-morbid tic-related class is predominantly male and characterized by high conscientiousness. The OCD co-morbid affective-related class is predominantly female, has a young age at onset, obsessive–compulsive personality disorder (OCPD) features, high scores on the ‘taboo’ factor of OCD symptoms, and low conscientiousness.ConclusionsOCD can be classified into three classes based on co-morbidity. Membership within a class is differentially associated with other clinical characteristics. These classes, if replicated, should have important implications for research and clinical endeavors.

Emergence of Symptoms of Tourette's Syndrome during Fluvoxamine Treatment of Obsessive–Compulsive Disorder

1994 ◽  
Vol 164 (6) ◽  
pp. 839-841 ◽  
Author(s):  
S. Fennig ◽  
S. Naisberg Fennig ◽  
M. Pato ◽  
A. Weitzman
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

A 14-year-old boy with obsessive–compulsive disorder (OCD) developed, under fluvoxamine treatment, acute symptoms of Tourette's syndrome (TS) with aggravation of the OCD. The TS symptoms did not respond to dopamine blockers and disappeared only after withdrawal of fluvoxamine. Readministration of fluvoxamine caused a re-emergence of the same symptoms.

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